Optimal control synthesis in therapy of solid tumor growth

A mathematical model of tumor growth therapy is considered. The total amount of a drug is bounded and fixed. The problem is to choose an optimal therapeutic strategy, i.e., to choose an amount of the drug permanently affecting the tumor that minimizes the number of tumor cells by a given time. The problem is solved by the dynamic programming method. Exact and approximate solutions to the corresponding Hamilton-Jacobi-Bellman equation are found. An error estimate is proved. Numerical results are presented.     

一类动态规划的解法及其在Turbo码解码中的应用

研究一类多阶段动态规划问题,给出了求最优解的方法.将这种多阶段动态规划应用于Turbo译码中,不仅可以减少运算量,还可以避免传统的Turbo译码算法需要进行指数运算以及其随着迭代次数的增加容易出现的数据溢出问题,因此是一种十分有效的方法,是对系统工程理论应用领域的拓宽.     

k紧优双环网的无限族的构造

双环网是计算机互连网络和通讯系统的一类重要拓扑结构,已广泛应用于计算机互连网络拓扑结构的设计中.利用L形瓦理论,结合中国剩余定理和二次同余方程的性质,给出了不同于参考文献中的任意k紧优双环网的无限族的构造方法,证明了对任意正整数k,若n(t)=3t2 At B,A=1,3,5,对于一定的B＞(k 1)2,均存在正整数t,使得{G(n(t);s(t))}是k紧优双环网的无限族,而且这样的无限族有无穷多类.作为定理的应用,给出了多类新的k紧优双环网的无限族.     

On the existence of catching-up optimal solutions for Lagrange problems defined on unbounded intervals

In this paper, we are concerned with the question of the existence of optimal solutions for infinite-horizon optimal control problems of Lagrange type. In such problems, the objective or cost functional is described by an improper integral. As dictated by applications arising in mathematical economics, we do nota priori assume that this improper integral converges. This leads us to consider a weaker type of optimality, known as catching-up optimality. The results presented here utilize the classical convexity and seminormality conditions typically imposed in the existence theory for the case of finite intervals. These conditions are significantly weaker than those imposed by other authors; as a consequence, their existence results are contained as special cases of the results presented here. The method of proof utilizes the Carathéodory-Hamilton-Jacobi theory previously developed by the author for infinite-horizon optimal control problems.This research forms part of the author's doctoral dissertation written at the University of Delaware, Newark, Delaware under the supervision of Professor T. S. Angell.     

Finite-Time Optimal Control of Polynomial Systems Using Successive Suboptimal Approximations

It is shown in this paper that the finite-time optimal control of polynomial systems can be obtained by solving a sequence of optimal control problems for the linearized problem. The paper provides proof of convergence as well as illustration of the procedure by two examples.     

Application of the sequential gradient-restoration algorithm to thermal convective instability problems

The problem of the thermal stability of a horizontal incompressible fluid layer with linear and nonlinear temperature distributions is solved by using the sequential gradient-restoration algorithm developed for optimal control problems. The hydrodynamic boundary conditions for the layer include a rigid or free upper surface and a rigid lower surface. The resulting disturbing equations are solved as a Bolza problem in the calculus of variations. The results of the study are compared with the existing works in the literature.The authors acknowledge valuable discussions with Dr. A. Miele.     

部分相干光学系统最佳象面的性质讨论

在部分相干理论的基础上,分别用表观传递函数和能量分布作评价指标,计算了部分相干光学系统的最佳象面位置,并讨论了其与相干度、空间频率及象差的关系。     

利用VB实现焊接方法的优化设计

对于某种母材和接头形式，当有多种焊接方法可实现焊接时，依据优化设计的思想．建立评价函数．用计算机对焊接方法进行优化设计．本文采用VB编制程序．当用户输入焊缝基本情况和对焊接质量、焊接效率及生产成本的要求时．即可得到最优、次优的几种焊接方法以供用户选择．并可选择打印某方法的焊接工艺卡片．     

Existence of optimal controls for a class of systems governed by differential inclusions on a Banach space

Using Cesari's approach, we prove the existence of optimal controls for a class of systems governed by differential inclusions on a Banach space having the Radon-Nikodym property. Theorem 3.1 gives the existence result for optimal relaxed controls under fairly general assumptions on the system and the admissible controls. This result depends on a fundamental result (Theorem 2.1) that proves the existence of mild solutions of differential inclusions on a Banach space, which has also independent interest. Further, the preparatory results, such as Lemma 3.1 and Lemma 3.2, are also useful in the study of time-optimal and terminal control problems.For illustration of the results, we present two examples, one on distributed controls for a class of systems governed by nonlinear parabolic equations and the other on boundary controls with discontinuous boundary operator.This work is supported in part by the National Science and Engineering Council of Canada under Grant No. 7109.