数字全息形貌测量的基本特性分析

在对数字全息技术进行严格理论分析的基础上，本文指出随单个CCD像元的尺寸的减小可能被记录物体的横向尺寸将变大，所允许的纵向尺寸却变小；另一方面其系统误差和被测量值本身的大小成正比，和横向分辨率成反比。     

TaqMan技术快速定量检测人巨细胞病毒的早期感染

采用实时TaqMan技术快速定量检测血清中的人巨细胞病毒(HCMV)感染,在HCMV保守性的Major IE基因区段设计了一对引物和一条Taqman探针,在LightCycler及Rotor-Gene定量检测仪上检测HCMV DNA.试验证明,两种仪器定量结果具有一致性,以PCR模板浓度来定义,敏感度达到1.0×102拷贝/μL,线性范围为1.0×102～1.0×108拷贝/μL.应用该方法与ELISA法对40例临床婴幼儿患者血清同时进行HCMV检测,结果显示TaqMan法与ELISA法相关性不高,前者更适于HCMV感染早期的定量检测,提示该法可应用于孕妇及新生儿HCMV筛查,并有助于疗效监测和评估.     

30GHz RF脉冲压缩器设计

为得到脉宽150ns，功率超过100MW的30GHz微波脉冲，采用MSLED-II原理设计了30GHz RF-脉冲压缩器。H-Hybrid，TE100口-TE10o模式转换器等器件都采用了新型设计，所有微波器件的设计充分考虑了高功率下的适用性，没有容易引起打火的调谐杆、容性膜片等部件。在微波器件的设计中用HFSS软件进行了详尽的模拟。加工并测试了H-Hybrid，且用在CERN的RF脉冲展宽器上。     

糖尿病、鼻咽癌的头发分析模拟诊断

以糖尿病病人和鼻咽癌病人为例，建立了基于头发微量元素含量，可用于辅助筛选或识别病人的一种定量指标——动态诊断指标。模拟诊断显示，该定量指标具有较高的辨别一个人是否患有某种疾病(在此，为糖尿病或鼻咽癌)的准确率，其实际应用值得进一步探讨。     

Fuzzy数学在涡喷发动机滑油故障诊断中的应用

将模糊数学方法引入到涡喷发动机滑油故障诊断中 ,提出了由历史数据及专家优序数综合确定模糊隶属度的方法 ,建立了模糊诊断模型 ,解决了针对一种或数种故障征兆 ,如何准确 ,快速地找到引起故障的真正原因 ,从而为飞机的故障诊断维修工作提供了一种科学、可行的新方法 .     

企业系统物元分析与诊断

本文根据可拓理论，从功能角度给出系统物元的整合效果模型，依此模型分析与诊断工业企业系统，并对其调节控制和发展演化机制进行了描述。     

Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin IX in skin and blood

The fluorescence and photosensitivity of endogenously synthesized protoporphyrin IX (PPIX) is increasing used for the diagnosis and treatment of malignant and certain non-malignant diseases. A selective accumulation of PPIX can be induced by application of 5-aminolevulinic acid (5-ALA), which is a precursor of PPIX in the cellular biosynthetic pathway of heme.

The purpose of this study was to monitor the in vivo accumulation of PPIX in different locations of the skin after oral ingestion and to determine the pharmacokinetics of 5-ALA and PPIX in human blood plasma for various routes of application. At the same time we wanted to achieve an optimal treatment scheme but also study possible side-effects of 5-ALA administration.

After oral application of 5-ALA in a concentration of 40 mg kg⁻¹ body weight, the fluorescence intensities of PPIX in the skin showed maxima between 6.5 and 9.8 h depending on the location and decreased to values lower than 5% related to the maximum after a mean time of about 40 h. The measured absolute intensities of PPIX fluorescence varied strongly between different patients and different locations on one patient. In the plasma of blood samples, PPIX could be detected via its fluorescence for all studied routes of application with the exception of the ointment, where PPIX levels were below the detection limit of 1 μg l⁻¹. The highest mean concentration of 742 μg l⁻¹ PPIX in the plasma was measured 6.7 h after oral application. For inhalation of 5-ALA, a mean maximum concentration of 12 μg l⁻¹ could be detected 4.1 h after application, for intravesical instillation, the mean maximum concentration was found to be 1 μg l⁻¹ 2.9 h after application. The kinetics of 5-ALA in the plasma peaked much earlier with a maximum concentration of 32 mg l⁻¹ about 30 min. after oral administration. The 5-ALA levels did not exceed normal reference values after topical application.

The results of our experiments suggest that for a systemic application of 5-ALA side-effects in sensitive patients cannot be excluded.     

台风西折路径的物理诊断

利用欧州中心格点场资料，对7例近海北上西折台风进行诊断分析.结果表明，当达到一定强度的台风西折时，在其移动路径左前侧常有暖平流增强，水汽通量辐合增大，不稳定层结加强，高空辐散和整层气旋性环流增加以及在这些物理变量中心增大区相迭加地区有整层降高中心，从而引起台风将向负变高中心移动.     

基于模糊综合评价的商务网站质量诊断

高质量网站是企业成功开展电子商务的关键,如何确定影响网站质量的主要因素常常困扰着技术维护人员.鉴于商务网站的复杂性和质量评价的模糊性特点,提出了基于多属性多层次模糊综合评价模型的质量诊断方法,通过对国内某著名商务网站进行质量诊断的算例详细说明了诊断的步骤并验证了该方法的有效性,并讨论了质量评价和诊断系统实施和进一步提高评价结果客观性的方法.     

Multifiber optical catheter with bending control of distal end: Applications of Raman biospectroscopy

This work demonstrates a multifiber optical catheter with bending control of the distal end, whose main use is to collect Raman signal for biospectroscopy. Also, a method for fiber background subtraction is presented, allowing removal of fiber emission peaks from gross Raman spectrum. The fiber optic catheter with seven fiber optics wrapped up in a resin and a biocompatible flexible teflon tube has been modified to incorporate a mechanical device with gauntlet, which allows bending of the distal extremity to access a desired location obeying the anatomy of the organ. The mechanical device (gauntlet) was built halfway from the catheter proximal excitation tip, allowing the bending of the distal end of about 38 mm diameter. Dispersive Raman spectra at 785 nm excitation wavelength from samples were measured without and with bending (from 120 mm decreasing to 14 mm) of the distal end of the catheter. An optical catheter without the gauntlet was used as a reference. Results demonstrated that both catheters (with bending mechanism and standard one) had about the same Raman signal when the device was bent semicircularly to 38 mm diameter (bending limit for the mechanism), with negligible implication to the Raman signal-to-noise relation (SNR) from sample. When both catheters were bent in a full turn, the Raman signal decreased to about 40% when bending reached 14 mm diameter, mainly due to losses introduced by changes in the fiber total internal reflection. The background removal was efficient, with minimum residual from fiber peaks. This optical catherer could be very useful in laser diagnosis and clinical applications, introducing a way to control the fiber tip position and angle on the tissue or organ. Published in Zhurnal Prikladnoi Spektroskopii, Vol. 74, No. 1, pp. 97–102, January–February, 2007.