δ修正Cramér-von Mises检验的非无偏性

在简单假设下,证明了对任意给定水平α∈(0,1)和样本容量n,δ修正Cramér-von Mises检验的非无偏性.     

基于局域均值滤波的Stoilov改进算法

Stoilov算法中相移量的计算依赖于采集到的变形条纹图的光强,存在对光强的减法、除法和开方等运算,使相位计算时在某些位置出现分子分母为零或开方为复数等奇异现象,导致相位展开无意义或出现超大误差。从而使三维面形重构出现畸变、失真,甚至无法进行三维重构。大量实验说明这些奇异点都是孤立的点,本文提出一种基于局域均值滤波的方法对Stoilov算法进行改进,首先对奇异点进行标记,然后依次用其周围8个点中的非奇异点的平均值代替该奇异点的值。实验结果表明,该方法在考虑传感系统带来的误差的情况下,有效抑制了奇异现象,提高了三维测量精度。     

提升格式下几种去噪方法的比较

本文比较了四种去噪声的效果,利用提升格式设计的灵活性,通过预算子或更新算子的设计最优匹配特定的信号,比较了软阈值函数、硬阈值函数、比例萎缩LAWML法和小波域中值滤波四种去噪方法.     

Synthesis,pharmacological evaluation,and molecular modeling studies of novel isatin hybrids as potential anticancer agents

A novel series of isatin hybrids 5a-g was designed, synthesized, and characterized spectroscopically. The synthesized compounds were evaluated for their cytotoxic activity against the human breast cancer cell line (MCF-7) by in vitro MTT assay. Amongst the tested compounds, 5e compound bearing benzyl moiety at N₄ piperazine was found to be the most active with the promising IC₅₀ (12.47 µM). Moreover, the active compounds 5e and 5g were subjected to antitumor evaluation (in vivo) against Dalton’s ascitic lymphoma (DAL) cell line and the results suggested that the best active compound 5e can normalize the blood picture in comparison to the standard drug. An in silico molecular docking study using the crystal structure of Hsp90 protein described the role of significant protein–ligand interactions and revealed more insights into the binding mode. The drug-likeliness of the compounds was predicted based on Lipinski's rule of five and pharmacokinetic ADME parameters. Hence, the synthesized isatin hybrids could be novel starting point anticancer lead compounds demonstrating drug-like properties which can be explored further for anticancer drug discovery.