具有遗传性疾病和性状的遗传位点分析

随着信息技术的进步和发展,现代生物学越来越多地将这些技术用于大规模生物数据的收集、分析、挖掘等过程.大量计算机技术,特别是统计方法被用来进行复杂疾病的分析.大量研究表明,人体的许多表型性状差异以及对药物和疾病的易感性等都可能与某些位点相关联,或和包含有多个位点的基因相关联.因此,定位与性状或疾病相关联的位点在染色体或基因中的位置,能帮助研究人员了解性状和一些疾病的遗传机理,也能使人们对致病位点加以干预,防止一些遗传病的发生.利用随机森林方法、Bootstrap重抽样、logistic回归等大数据分析方法,意在解决优化生物学位点关联性分析中单一致病位点识别、多位点相互作用和多性状位点关联性分析等子问题.     

股票市场的长记忆及其动态结构

本文提出了结合平均小波系数法和自回归原始自助法的稳健长记忆检验,蒙特卡罗模拟显示该方法对于短期记忆过程具有稳定性。基于该方法对2005年4月8日至2015年6月30日的中国、美国、香港和德国股市进行了实证分析。全局检验结果表明仅中国的股票市场存在显著的长记忆,并且风险因素无法对长记忆解释,而美国、德国和香港的股市不存在长记忆。基于递增窗口的动态Hurst指数分析显示,金融危机时期4个股市都存在显著的长记忆。2010年后,除中国股市外,其余三个股市几乎不存在长记忆现象。     

Identification of the Physical Parameters Used in the Thermo-Hygro-Mechanical Model

This paper describes different methods used to identify a large number of physical parameters of the thermo-hygro-mechanical coupling model. This model is developed on the basis of mechanics of porous media and deals with the prediction of response of a structure submitted to thermal, hygrometric and mechanical loading. The aim of this work is mainly to propose some experimental methods for the determination of physical parameters used previously in the model such as hygrometric parameters (liquid Biot's coefficient b _l , vapour and liquid permeability _v, _l and tangent capillary modulus N _ll). Thermal parameters such as thermal conductivity (), specific heat (C) and the thermo-hydrous expansion coefficient ( _i ^p ) have been identified using some works published previously. The different physical parameters were identified in the case of cement mortar without taking into account the influence of hysteresis.     

软土地区人工冻土无侧限瞬时抗压强度的试验研究

冻结法施工在上海隧道建设中(如隧道旁通道、地下泵房等的设计与施工)得到广泛应用,也曾引发过严重的地质灾害(如上海地铁4号线外滩段的地质灾害)。因此安全、经济、合理地将冻结法用于上海软土地区隧道建设中已经成为上海工程建设中的一个重要的研究课题。本文以上海复兴东路越江隧道旁通道冻结法施工中遇到的第⑥层粉质粘土及第⑦层粉细砂为研究对象,针对设计冻结壁重要强度参数无侧限瞬时抗压强度,进行了室内试验研究,揭示了两种土的冻结强度随温度的变化关系,同时研究了粉细砂的冻结强度随含水率的变化规律。     

不同体型建筑物尾流作用下的高层建筑的风荷载特性

采用高频底座力天平方法,研究了不同断面形状的施扰建筑对一典型断面受扰建筑的静力和动力干扰影响,分析了正方形断面施扰建筑和非正方形断面施扰建筑的干扰效应的差异和产生差异的干扰机理。结果表明:施扰建筑断面形状的改变对静力干扰的影响不显著,但对于动力响应方面则有非常明显的影响。由于位于上游的切角断面施扰建筑脱落的在其尾流中的漩涡频率要明显大于正方形断面施扰建筑的涡脱频率,使得其产生的最大包络动力干扰因子值(EIF)要显著高于断面为正方形施扰建筑的EIF值,最大可达4.41(顺风向)和3.69(横风向),相比断面为正方形的高出142%和82.7%。     

Indentation tests investigation of mechanical behavior of two-dimensional materials

准确了解二维材料的力学性能对于推动其应用具有重要意义, 无基底压痕技术是目前最广泛采用的二维材料力学性能测试方法之一, 本文综述了二维材料压痕研究的最新进展以及所面临的问题, 并对将来的研究工作进行了展望.无基底压痕技术是将二维材料转移到带有沟槽或柱形孔的基底上, 制备二维材料"梁"和"鼓"模型, 然后利用原子力显微镜测量其在压针作用下的载荷--位移关系, 最后通过基于连续介质薄膜导出的压痕响应分析模型拟合实验结果, 估算出二维材料的弹性模量和本征强度.由于二维材料的厚度远小于连续介质薄膜, 来自于压头以及基底孔侧壁的范德华力对二维材料的压痕响应具有显著影响, 造成二维材料与传统压痕分析模型中的基本假设不符, 导致不能准确预测二维材料的弹性模量; 另外, 由于传统压痕模型无法准确描述二维材料在大变形下的非线性行为, 以及由缺陷等引起的应力集中, 导致由压痕测试表征的二维材料(特别是多晶二维材料)本征强度具有较大的偏差. 因此, 一方面需要正确了解由压痕技术获得的二维材料力学性能, 另一方面还需对目前的研究方法做进一步的改进和完善.     

An exact deformation analysis for the magneto-electro-elastic fiber-reinforced thin plate

A closed form expressions for bending problem of magneto-electro-elastic (MEE) rectangular thin plates are derived, the exact solutions for the deformation behaviors of the fiber-reinforced BaTiO₃/CoFe₂O₄ composites subjected to certain types of surface loads are analytically obtained. Based on Kirchhoff thin-plate theory, structural characteristics such as elastic displacements, electric potential and magnetic induction for magneto-electro-elastic (MEE) rectangular plates are investigated, the governing equation in terms of the transverse displacement is presented in a rather compact form due to the omission of the transverse shear deformation and rotatory inertia. The material coefficients for the MEE plate can be uniquely expressed by the volume-fraction (v.f.) of piezoelectric constituent BaTiO₃ in the fiber-reinforced composite, and are tabulated with 25% offset of the volume-fraction. The deformation variations of the MEE thin plate with closed-circuit electric restriction are evaluated analytically according to their specified boundary conditions, and the effects of the volume-fractions on the deformations variations are discussed. It can be found that all the results obtained by using the proposed model have reached good agreements with the other available research works, whereas, the present study provides a much simpler way in seeking the analytic solutions for the interactively coupled quantities of a multiphase medium.     

A unifying theorem for Newton’s method on spaces with a convergence structure

We present a semilocal convergence theorem for Newton’s method (NM) on spaces with a convergence structure. Using our new idea of recurrent functions, we provide a tighter analysis, with weaker hypotheses than before and with the same computational cost as for Argyros (1996, 1997, 1997, 2007) [1], [2], [3] and [5], Meyer (1984, 1987, 1992) [13], [14] and [15]. Numerical examples are provided for solving equations in cases not covered before.