PALB2 as a potential prognostic biomarker for colorectal cancer

Partner and localizer of BRCA2 (PALB2) is regarded as a colorectal cancer (CRC) risk gene, but the prognostic implication of PALB2 in CRC remains unclear. In this study, we evaluate the prognostic value of the gene copy number alteration (CNA) and mRNA expression of PALB2 in The Cancer Genome Atlas (TCGA) database, and then validated with our database. We downloaded the copy number and mRNA data of PALB2 from TCGA database and examined the relationship among the genetic alterations, expression levels and survival outcomes. Gene ontology (GO) analysis was performed to study the function of PALB2. cBioPortal database was used to explore the potential co-expression genes of PALB2. There were 6.3% (37 of 582) CRC patients diagnosed as PALB2 gene deletion. The PALB2 deletion group expressed significantly lower of PALB2 mRNA than the non-deletion group (P < 0.001). Survival analysis showed that PALB2 deletion was significantly associated with shorter disease-free survival (DFS) (P = 0.026) and overall survival (OS) (P = 0.028). Low mRNA expression of PALB2 correlated with shorter OS (P < 0.001). Multivariate analysis also confirmed that PALB2 deletion and low mRNA expression of PALB2 were independent prognostic factors of poor OS in CRC (P = 0.019, 0.034, respectively). In validation cohort, negative expression of PALB2 was associated with shorter OS (P = 0.006) in stage I patients. Multivariate analysis confirmed that negative expression of PALB2 was a poor-prognostic factor (P = 0.002). GO analysis and co-expression analysis investigated that PALB2 is primarily involved in the DNA repair process. These results suggest that PALB2 gene copy number deletion and low mRNA expression could be novel prognostic biomarkers for CRC.     

任意随机变量序列的一个强极限定理

研究任意随机变量序列的强收敛性.利用鞅差序列级数收敛定理,证明了任意随机序列的一个强极限定理,作为推论,得到了马氏过程、鞅差序列及独立随机变量序列的强大数定律.     

平面波经小圆孔非傍轴衍射的轴上光强解析分析

用亥姆霍兹 基尔霍夫积分定理和基尔霍夫边界条件,推导出了平面波经小圆孔非傍轴衍射时轴上强度的简单解析表达式,研究了平面波经小圆孔后整个衍射空间非傍轴的轴上光强分布.给出了计算圆孔菲涅尔数的精确公式,重新检查了通常的菲涅尔数公式的有效性.数值计算显示,应用解析表达式所得的结果与应用衍射积分公式所得的结果完全一致.     

修理设备可更换且修理有延迟的两不同型部件并联可修系统

假定部件的寿命服从指数分布,其修理延迟时间和修理时间均服从一般分布,并且修理设备的寿命服从指数分布,其更换时间服从一般分布,利用马尔可夫更新过程理论和一种新的分解方法,研究了修理设备可更换且修理有延迟的两不同型部件并联可修系统,求得了系统和修理设备有关可靠性指标的一系列结果.     

Electrochemical characteristics of the blended polymer electrolytes containing lithium salts

Blend-based polymer electrolytes composed of poly(ethylene oxide), poly(oligo[oxyethylene]oxysebacoyl), and lithium salts have been prepared. These polymer electrolytes have been investigated in terms of ionic conductivity, transport number, and interfacial characteristics of the lithium electrode in contact with the polymer electrolyte. The influences of the blend composition, the salt used, and its concentration on the electrochemical behavior were studied. © 1996 John Wiley & Sons, Inc.     

正整数的一类三分拆的应用

利用正整数n的一类特殊的3分拆n=n1+n2+n3,n1>n2>n3≥1,且n2+n3>n1的Ferrers图将不定方程4x1+3x2+2x3=n(n≥9)的正整数解与这种分拆联系起来,从而得到了该不定方程的正整数解数公式;同时也给出了正整数n的一类4分拆的计数公式.此外,还给出了周长为n的整边三角形的计数公式的一个简单证明.     

超声波燃气表矩形流道的雷诺修正系数仿真研究

在超声波流量计测量技术中, 雷诺修正系数相关的研究对于提高计量精度有重要作用. 为研究矩形流道的雷诺修正系数与雷诺数的关系, 对矩形流道在常温常压流量较小情况下进行仿真, 结果发现: 矩形流道层流状态下的雷诺修正系数与雷诺数呈线性相关. 保持压强、体积流量不变, 在不同温度下进行仿真及拟合, 结果表明: 在不同温度下雷诺修正系数与雷诺数的线性关系依然满足. 在上述实验基础上, 对矩形流道湍流状态下的雷诺修正系数与雷诺数关系进行研究, 通过改变温度、压强和体积流量进行仿真及拟合发现, 矩形流道湍流状态下雷诺修正系数与雷诺数呈非线性相关.     

弱耦合多原子半无限晶体中磁极化子的激发能量

近年来国内外对多原子极性晶体中磁极化子性质的研究十分活跃,Zorkani等采用变分法计算了束缚磁极化子的基态能量,Kandemir等采用束缚朗道态讨论了二维大磁极化子的基态和第一激发态能量,国内一些学者采用微扰法和新颖算符法讨论了多原子极性晶体中表面和体磁极化子的性质。采用线性组合算符和幺正变换,研究磁场中多原子半无限极性晶体中电子和光学声子弱耦合相互作用所产生的极化子的第一激发态能量及平均声子数。结果表明:当电子无限接近晶体表面时,磁极化子的基态能量仅为Landau能量;第一激发态能量为Landau基态能量的2倍;平均声子数等于各支与电子耦合的体光学声子数和表面光学声子数之和。而当电子处于晶体深处时,磁极化子的基态能量却为Landau基态能量与各支体光学声子以及表面光学声子分别耦合的能量之和;第一激发态能量仍为Landau基态能量的2倍;平均声子数等于各支与电子耦合的体光学声子数和与所处深度有关的各支体光学声子数之和,而与各支表面光学声子无关。