具预警功能的三部件并联可修复系统的可靠性分析

研究了具有预警功能的三部件并联且有两个热备器的可修复系统,系统可转化为一个Banch空间上的抽象Cauchy问题.首先利用半群理论证明了该系统强解的存在唯一性,其次运用了代数方法证明了0是系统算子的简单本征值,最后对系统和不含预警功能的系统的可用度进行了比较分析.     

基于前失速先兆检测机理的叶顶喷气扩稳实验研究

拓宽轴流压气机稳定工作裕度及探索其流动失稳控制途径一直是内部流动研究的焦点。本文从前失速先兆检测机理入手,对前失速先兆与叶顶间隙泄漏流非定常性进行了关联性研究,发现了前失速先兆与叶顶间隙泄漏流非定常性有一定的关联性。在认识这类关联性的基础上,提出了基于前失速先兆捕捉的失稳控制途径,并结合DSP控制器构建扩稳控制方案,在低速轴流压气机上进行了实验验证。实验结果表明:采用叶顶喷气扩稳控制措施后,简化了原来复杂的控制机构,并为控制措施的实施预留了反馈控制时间,与原来的定常喷气控制措施相比有变工况自适应的优势。     

Genetic association of the EGR2 gene with bipolar disorder in Korea

The early growth response gene 2 (EGR2) is located at chromosome 10q21, one of the susceptibility loci in bipolar disorder (BD). EGR2 is involved in cognitive function, myelination, and signal transduction related to neuregulin-ErbB receptor, Bcl-2 family proteins, and brain-derived neurotrophic factor. This study investigated the genetic association of the EGR2 gene with BD and schizophrenia (SPR) in Korea. In 946 subjects (350 healthy controls, 352 patients with BD, and 244 with SPR), nine single nucleotide polymorphisms (SNPs) in the EGR2 gene region were genotyped. Five SNPs showed nominally significant allelic associations with BD (rs2295814, rs61865882, rs10995315, rs2297488, and rs2297489), and the positive associations of all except rs2297488 remained significant after multiple testing correction. Linkage disequilibrium structure analysis revealed two haplotype blocks. Among the common identified haplotypes (frequency > 5%), 'T-G-A-C-T (block 1)' and 'A-A-G-C (block 2)' haplotypes were over-represented, while 'C-G-G-T-T (block 1)' haplotype was under-represented in BD. In contrast, no significant associations were found with SPR. Although an extended analysis with a larger sample size or independent replication is required, these findings suggest a genetic association of EGR2 with BD. Combined with a plausible biological function of EGR2, the EGR2 gene is a possible susceptibility gene in BD.     

Laser-Induced Fluorescence Bronchoscopy for Detection and Localization of Early Lung Cancer

Experimenatal results on the development of a Laser-Induced Fluorescence Bronchoscopy(LIFB) for the detection and localization of early lung cancer are reported in this paper. The system utilizes fluorescence of photosensitizer drug to provide real time video imaging for the examined lung tissue. Color filters are used to differentiate signal from background and a computer image processing technique is also applied to subtract the background. Moreover, a pseudocolor contrast enhancement method was developed to enhance the fluorescence image displayed on the vidio monitor. Suspicious areas are identified by pseudocolor image to guide biopsy, and several clinical trials show that sensitivity and contrast capability of the system should permit the detection and localization of early lung cancer.     

幼儿反复呼吸道感染与头发中微量元素含量关系研究

报道了2886名正常儿童与718例反复呼吸道感染儿童头发中微量元素含量对比研究结果。研究表明,患儿的身高、体重和发Zn明显低于正常儿童,而发Cu、Ca、Pb则明显高于正常和童。因子提取分析显示,Zn和Pb在儿童反复呼吸道感染发病中起非常重要的作用。患反复呼吸道感染儿童约占儿童总数的20％左右。     

A Pricing Model for American Options with Gaussian Interest Rates

In this paper we introduce a new methodology to price American put options under stochastic interest rates. We derive an analytic approximation that can be evaluated very fast and is fairly accurate. The method uses the so-called forward risk adjusted measure to derive analytic prices. We show that for American puts the correlation between the stock price and the interest rate has different influences on European option values and early exercise premiums.     

Indicator space configuration for early warning of violent political conflicts by genetic algorithms

Recognition of preconflict situations has a powerful potential for early warning of violent political conflicts. This paper focuses on the design and application of artificial neural networks as classifiers of preconflict situations. Achieving a desired level of performance of the neural network relies on the appropriate construction of recognition space (selection of indicators) and the choice of network architecture. A fast and effective method for the design of reliable neural recognition systems is described. It is based on genetic algorithm techniques and optimizes both the configuration of input space and the network parameters. The implementation of the methodology provides for increased performance of the classifier in terms of accuracy, generalization capacity, computational and data requirements. This revised version was published online in June 2006 with corrections to the Cover Date.     

Trident Nano-Indexing the Proteomics Table: Next-Version Clustering of Iron Carbide NPs and Protein Corona

Protein corona composition and precise physiological understanding of differentially expressed proteins are key for identifying disease biomarkers. In this report, we presented a distinctive quantitative proteomics table of molecular cell signaling differentially expressed proteins of corona that formed on iron carbide nanoparticles (NPs). High-performance liquid chromatography/electrospray ionization coupled with ion trap mass analyzer (HPLC/ESI-Orbitrap) and MASCOT helped quantify 142 differentially expressed proteins. Among these proteins, 104 proteins showed upregulated behavior and 38 proteins were downregulated with respect to the control, whereas 48, 32 and 24 proteins were upregulated and 8, 9 and 21 were downregulated CW (control with unmodified NPs), CY (control with modified NPs) and WY (modified and unmodified NPs), respectively. These proteins were further categorized on behalf of their regularity, locality, molecular functionality and molecular masses using gene ontology (GO). A STRING analysis was used to target the specific range of proteins involved in metabolic pathways and molecular processing in different kinds of binding functionalities, such as RNA, DNA, ATP, ADP, GTP, GDP and calcium ion bindings. Thus, this study will help develop efficient protocols for the identification of latent biomarkers in early disease detection using protein fingerprints.     

表面绝缘对平面钨丝阵Z箍缩早期过程的影响

在强光一号装置上研究了表面绝缘对平面钨丝阵早期过程的影响。通过对实验结果的唯象分析,发现相对于标准丝阵,表面绝缘丝阵X射线辐射被强烈延迟,并与丝阵宽度有较强的依赖关系,在X射线辐射之前存在较强的阴极发射;表面绝缘丝阵X射线辐射副脉冲幅值是标准丝阵两倍,且存在较长的平台期,其单丝等离子体膨胀导致的温度降低效应比标准丝阵强;在快速内爆开始之前,两者形成了类似的宏观磁流体不稳定性结构。     

族以人重：明清之际魏塘钱氏的家族网络与政治变动

晚明江南地方社会的发展进程中,地方上势家大族起了很多积极作用。通过这些大族地方生活的轨迹,可以知晓其最重要的姻亲网络及核心家族间的链接关系。在浙江嘉善县,堪称权势阶层主流的钱氏等家族,对国家保持着高度忠诚,没有在地方上发展为垄断州县行政的“宗族社会”。在清兵南下后,这些大族的变化与家族成员的人生遭际,呈现出比较复杂的样态,也折射出王朝统治变化进程中地方的政治脉动和士人的家国情怀。从钱氏族人的生死往事、已逝的生活世界,可以探求和理解明清之际士人生活的状态及其生存之道,他们处于交互编织的网络中,既包括社会身份,也包括本土秩序,形塑了地方社会形态,影响了地方历史的主流变化。钱家在长期的发展过程中,已构造出了相对稳定的生活方式、丰富的家族遗产、接近一致的信仰以及大族共有的文化氛围。在以亲属关系为基础的社会结构中,钱家的那些代表人物,渗透至社会与文化生活的各个方面,都有所谓“链接性角色”的作用,建立起一种无限复杂的“微权力”网络。因此也可以解释,在一个具体的生活环境与地域社会中,因为有了这样具有“结构”性力量的社会阶层存在,晚明以来足以表现地方的人物,就是那样一些官绅士人而非其他的原因。