Integrating approach to discover novel bergenin derivatives and phenolics with antioxidant and anti-inflammatory activities from bio-active fraction of Syzygium brachythyrsum

Syzygium brachythyrsum is an important folk medicinal and edible plant in Yunnan ethnic minority community of China, however, little is known about the chemical and bio-active properties. The present study is aimed to identify the bioactive constituents with antioxidant and anti-inflammatory properties by an integrating approach. First, two new bergenin derivatives, brachythol A (1) and brachythol B (2), together with eleven known phenolic compounds (3–13) were isolated from bioactive fractions by phytochemical method. Among these isolated chemicals, five bergenin derivatives, along with 3 phenolics were found in Syzygium genus for the first time. Then, a further chemical investigation based on ultra-high-performance liquid chromatography-Q Exactive Orbitrap mass spectrometry resulted in a total of 107 compounds characterized in the bio-active fractions, including 50 bergenin derivatives, among which 14 bergenin derivatives and 14 phenolics were potential new natural chemicals. Most of the isolated compounds showed obvious antioxidant activities, while compounds 11, 12, and 13 had favorable performance. Eight compounds (2–5, 7, and 9–11) showed good inhibitory activity on nitric oxide (NO) production in macrophage RAW 264.7 cells. The structure–activity correlation analysis indicated that the antioxidation and anti-inflammatory activities enhanced when bergenin was esterified with gallic acid, caffeic acid or ferulic acid. This is the first report of bergenins in Syzygium genus and the richness in new bio-active bergenins and gallic acid derivatives indicated that Syzygium brachythyrsum is a promising functional and medicinal resource.     

La0.67Ba0.33MnO3中Bi掺杂产生的低场磁电阻增强效应

将Bi2O3掺杂到溶胶-凝胶法制备的La0.67Ba0.33MnO3(LBMO)微粉中, 结果发现随着Bi的掺杂, 材料的磁化强度和居里温度基本不变, 但电阻率发生明显变化, 在0～10% (摩尔分数)的掺杂范围内, 电阻率先急速上升后缓慢降低. 掺Bi可以使低温下的低场磁电阻得到显著增强, 但并不改变与双交换作用有关的本征磁电阻; 掺Bi也使室温下的磁电阻得到明显增强.     

多评价特征基元可拓集研究

在单评价特征基元可拓集的基础上,研究多评价特征基元可拓集的构造方法及其关联函数的建立方法,为多特征综合评价和多特征不相容问题求解提供理论依据和可操作的形式化、定量化方法,使多特征不相容问题的智能化处理成为可能.     

一类非线性系统的时滞相关H∞控制

本文研究一类非线性控制系统的时滞相关日。控制问题．首先通过构造恰当的Lyapunov泛函,设计非线性H∞控制器,得到了该类非线性控制系统渐近稳定的一个充分条件．其次通过建立具有线性矩阵不等式（LMI）约束的凸优化问题,得到了该类非线性系统的时滞相关H∞性能的一个充分条件．MATLAB仿真验证了本文方法的可行性．     

Numerical treatment of Jeffrey fluid with pressure‐dependent viscosity

In this paper, we have analyzed the Jeffrey fluid with pressure‐dependent viscosity. The equations of Jeffrey fluid model have been modelled when viscosity is a function of pressure. Two types of flow problem, namely, Poiseulle flow and Couette flow have been solved numerically for Jeffrey fluid. The velocity field for different physical parameters has been discussed through graphs. Copyright © 2010 John Wiley & Sons, Ltd.     

Improved Synthesis of Indirubin Derivatives by Sequential Build‐Up of the Indoxyl Unit: First Preparation of Fluorescent Indirubins

Indirubin, present in extracts of Isatis tinctoria and some other plant species, has promising cytotoxicity against a variety of cell lines by inhibition of cyclin‐dependent kinases. Chemical synthesis of its derivatives relies on the combination of isatins and 2,3‐dihydro‐1H‐indol‐3‐one (‘indoxyl’) derivatives and usually yields indigo as well as other by‐products. Inspection of the hydrolysis of the long‐known condensation products of 2‐thioxothiazolidin‐4‐one with isatins gave useful hints for an improved synthesis of indirubins: this reaction does not yield quinoline derivatives but 2‐(2,3‐dihydro‐2‐oxo‐1H‐indol‐3‐ylidene)‐2‐sulfanyl acetic acids. By substitution of the sulfanyl group in this oxindoles with anilines and straightforward cyclization under Nazarov conditions, a broad variety of indirubins substituted in the indoxyl ring system are thus available, usually in very good purity and yield. Use of naphthylamines in this reaction sequence yields various fluorescent substances with λ_fl at ca. 630 nm.     

Temperature compensation of dye doped polymeric microscale lasers

In this article, a new technique for building temperature compensated microscale lasers that are based on the morphology dependent resonances phenomenon is presented. The dome shaped resonator is made with a mixture of NBA 107 UV curable polymer and rhodamine 6 g dissolved in ethanol solution. Since polymers usually exhibit linear thermal expansion and thermo‐optic coefficients that are opposite in sign but similar in order of magnitude, it is possible to compensate for temperature over the dome shaped resonator by tuning the dye concentration and the ratio between the polymer and dye solution. Experiments with dye concentration between 10^?2 to 10^?3 M and polymer and dye solution ratios between 1:1 and 4:1 are conducted. The sensitivity for all cases is presented, and the quality factor Q is investigated. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017 , 55 , 789–792     

Visualization of age‐dependent myocardial metabolic impairment in cardiomyopathic model hamster obtained by fluorescent X‐ray computed tomography using I‐127 BMIPP

Fluorescent X‐ray computed tomography (FXCT) enables visualization of myocardial fatty acid metabolism by using non‐radio‐iodinated I‐5‐(p‐iodophenyl)‐3‐(R,S)‐methylpentadecanoice acid (BMIPP). In this experiment, age‐dependent myocardial metabolic impairment was successfully imaged and analyzed quantitatively in J2N‐k cardiomyopathic hamster using FXCT.     

Parabolic equations with non–linear, degenerate and space–time dependent operators

In this paper existence and regularity results for a class of degenerate nonlinear parabolic equations are proved. Indeed, the diffusion operator may degenerate as the solution diverges and may depend on space and time variables in a non–regular way, too. Some estimates on the behaviour of the solutions for t → +∞ are also given.