The role of mammalian autophagy in protein metabolism

Autophagy is in principle a non-selective degradation system within cells, which is conserved in all eukaryotic cells. Autophagy is usually suppressed at low levels but can be upregulated during periods of nutrient starvation, which facilitates cell survival. In addition to this fundamental role, basal autophagy was recently revealed to be important for constitutive turnover of intracellular proteins and organelles. Autophagy has been considered to be involved also in presentation of endogenous antigens, degradation of invasive bacteria, tumor suppression, cell death and development. This review will discuss the biological significance of autophagy, particularly focusing on its implications in protein metabolism in mammals.     

应用数据挖掘的束流状态描述建模

聚类分析是描述数据群体特征的有效方法.然而,随着挖掘数据库规模的增大,评分函数极值搜索是计算复杂度很高的问题.文中提出了一种新的算法,并将其运用到束流状态描述建模中.试验结果表明,该算法快速有效.同时,重复性是电子储存环的重要指标,聚类模型可作为机器研究和决策的依据,具有指导意义.     

聚甲基丙烯酸甲酯掺杂Ce3+的飞秒激光三维信息存储

用飞秒激光(200 fs,1 kHz,800 nm)脉冲在掺杂稀土离子Ce3 的聚甲基丙烯酸甲酯(PMMA)膜中进行了光存储实验研究,包括对样品的吸收光谱、激光照射前后的电子旋转共振(Electron spin resonance,ESR)光谱的测量和讨论。结果表明掺杂稀土离子Ce3 的聚甲基丙烯酸甲酯膜具有较低的写入阈值,有利于高速、并行的三维光存储。实验结果采用传统光学显微镜并行读出。给出了四层存储结果(点间距和层间距分别是4μm和16μm),并讨论了脉冲能量的大小对空腔尺寸的影响,进行高密度存储时,在保证读出信号灰度值足够大的情况下,应选择尽量小的激光脉冲写入能量。实验结果表明这种材料可以应用于三维光信息存储。     

Improvement of ultrasound speckle image velocimetry using image enhancement techniques

Ultrasound-based techniques have been developed and widely used in noninvasive measurement of blood velocity. Speckle image velocimetry (SIV), which applies a cross-correlation algorithm to consecutive B-mode images of blood flow has often been employed owing to its better spatial resolution compared with conventional Doppler-based measurement techniques. The SIV technique utilizes speckles backscattered from red blood cell (RBC) aggregates as flow tracers. Hence, the intensity and size of such speckles are highly dependent on hemodynamic conditions. The grayscale intensity of speckle images varies along the radial direction of blood vessels because of the shear rate dependence of RBC aggregation. This inhomogeneous distribution of echo speckles decreases the signal-to-noise ratio (SNR) of a cross-correlation analysis and produces spurious results. In the present study, image-enhancement techniques such as contrast-limited adaptive histogram equalization (CLAHE), min/max technique, and subtraction of background image (SB) method were applied to speckle images to achieve a more accurate SIV measurement. A mechanical sector ultrasound scanner was used to obtain ultrasound speckle images from rat blood under steady and pulsatile flows. The effects of the image-enhancement techniques on SIV analysis were evaluated by comparing image intensities, velocities, and cross-correlation maps. The velocity profiles and wall shear rate (WSR) obtained from RBC suspension images were compared with the analytical solution for validation. In addition, the image-enhancement techniques were applied to in vivo measurement of blood flow in human vein. The experimental results of both in vitro and in vivo SIV measurements show that the intensity gradient in heterogeneous speckles has substantial influence on the cross-correlation analysis. The image-enhancement techniques used in this study can minimize errors encountered in ultrasound SIV measurement in which RBCs are used as flow tracers instead of exogenous contrast agents.     

Constraints on models with a break in the primordial power spectrum

One of the characteristics of the “Matter Bounce” scenario, an alternative to cosmological inflation for producing a scale-invariant spectrum of primordial adiabatic fluctuations on large scales, is a break in the power spectrum at a characteristic scale, below which the spectral index changes from ns=1$n_s=1$ to ns=3$n_s=3$. We study the constraints which current cosmological data place on the location of such a break, and more generally on the position of the break and the slope at length scales smaller than the break. The observational data we use include the WMAP five-year data set (WMAP5), other CMB data from BOOMERanG, CBI, VSA, and ACBAR, large-scale structure data from the Sloan Digital Sky Survey (SDSS, their luminous red galaxies sample), Type Ia Supernovae data (the “Union” compilation), and the Sloan Digital Sky Survey Lyman-α forest power spectrum (Lyα) data. We employ the Markov Chain Monte Carlo method to constrain the features in the primordial power spectrum which are motivated by the matter bounce model. We give an upper limit on the length scale where the break in the spectrum occurs.     

Influence of annealing treatment on as-grown Ib-type diamond crystal at a high temperature and high pressure

In this paper,we report on the influence of annealing treatment on as-grown Ib-type diamond crystal under high pressure and high temperature in a china-type cubic anvil high-pressure apparatus.Experiments are carried out at a pressure of 7.0 GPa and temperatures ranging from 1700 C to 1900 C for 1 h.Annealing treatment of the diamond crystal shows that the aggregation rate constant of nitrogen atoms in the as-grown Ib-type diamond crystal strongly depends on diamond morphology and annealing temperature.The aggregation rate constant of nitrogen remarkably increases with the increase of annealing temperature and its value in octahedral diamond is much higher than that in cubic diamond annealed at the same temperature.The colour of octahedral diamond crystal is obviously reduced from yellow to nearly colorless after annealing treatment for 1 h at 1900 C,which is induced by nitrogen aggregation in a diamond lattice.The extent of nitrogen aggregation in an annealed diamond could approach approximately 98% indicated from the infrared absorption spectra.The micro-Raman spectrum reveals that the annealing treatment can improve the crystalline quality of Ib-type diamond characterized by a half width at full maximum at first order Raman peak,and therefore the annealed diamond crystals exhibit nearly the same properties as the natural IaA-type diamond stones of high quality in the Raman measurements.     

光谱流量标准化的高效计算

流量标准化是光谱数据挖掘中的一个基本环节,他对挖掘结果的精度和系统的效率均有重要影响,常用方法存在效率较低的问题,为此研究了光谱数据挖掘中流量标准化的算法设计和效率比较问题。首先,探讨了光谱流量标准化技术不同实现方案的渐进效率,给出了实现高效计算的算法,并分析了它们的时间复杂度和空间复杂度。然后,通过SDSS(sloan digital sky survey)的实测光谱数据,横向比较了不同流量标准化算法的效率差异。在光谱流量标准化算法的纵向理论研究中,主要考虑的是计算效率随数据规模增长的变化规律,是在极限意义下进行探讨。在横向实验比较中,考虑重点是不同算法中基本操作时间复杂度的差异及其对算法效率的影响。理论研究和实验结果表明,虽然四种标准化方法Smax,Smedian,Smean和Sunit的渐进效率的类型相同,但对常见的观测规模光谱数据来说,Smax和Smean的效率远远高于Sunit和Smedian,且常用的Sunit标准化方法效率最低。该研究对于在光谱数据挖掘和开发中,如何根据数据的规模,具体需求,从整体上考虑精度和效率的折衷,以确定合适的流量标准化方法有重要的参考价值。     

Competition Between Self-birth and Catalyzed Death in Aggregation Growth with Catalysis Injection

We propose two irreversible aggregation growth models of aggregates of two distinct species (A and B) to study the interactions between virus aggregates and medicine efficacy aggregates in the virus-medicine cooperative evolution system. The A-species aggregates evolve driven by self monomer birth andB-species aggregate-catalyzed monomer death in model I and by self birth, catalyzed death, and self monomer exchange reactions in model II, while the catalyst B-species aggregates are assumed to be injected into the system sustainedly or at a periodic time-dependent rate. The kinetic behaviors of the A-species aggregates are investigated by the rate equation approach based on the mean-field theory with the self birth rate kernel I_A(K)=Ik, catalyzed death rate kernel J_AB(k)=Jk and self exchange rate kernel K_A(k,l)=Kkl. The kinetic behaviors of the A-species aggregates are mainly dominated by the competition between the two effects of the self birth (with the effective rate I) and the catalyzed death (with the effective rate JB₀), while the effects of the self exchanges of the A-species aggregates which appear in an effectiverate KA₀ play important roles in the cases of I>JB₀ and I=JB₀. The evolution behaviors of the total mass M^A(t)₁ and the total aggregate number M^A(t)₀ are obtained, and the aggregate size distribution a_k(t) of species A is found toapproach a generalized scaling form in the case of I ≧ JB₀ and a special modified scaling form in the case of I0. The periodical evolution of the B-monomers concentration plays an exponential form of the periodic modulation.     

分布式计算机软件数据整合平台设计

为实现当前经济市场中各应用软件的整合,提高我国各行业间个性化软件的开发能力,加强企业间的科学化系统软件设立,保证企业的高效运行,以及质量和系统维护能力;根据较为常用的分布式计算机系统,提出一种软件数据整合平台的设计;以商用软件整合平台设计为例,以开发模式、服务、技术结构、功能为研究方向,在企业正常运行时,可以实现业务系统功能开发以及门户单点登录,提高企业的个性化系统应用和经济效益;本文根据以上基本需求提出该功能软件平台进行设计,并在实际应用中分析出对于当前企业发展所提供的助力;结果显示,在当前经济发展状况下,有效地使用软件数据整合平台可以很大程度上提高企业的科学化管理和有效的资源分配,使企业在市场竞争中提高经济效益和社会效益。     

基于数据驱动的航天器三维可视化系统设计

航天器数据庞大繁杂,为了给设计人员提供快速检验设计思想的便捷工具,对基于数据驱动的航天器三维可视化系统进行了研究。在分析航天器可视化系统特点的基础上,提出系统功能要求,继而提出了基于数据驱动的三维可视化系统构建方案,介绍了可视化系统组成、核心模块关系。在基于MFC框架及Vega Prime为主的开发的前提下,对系统模块划分进行了研究,给出模块功能和实现方案。为了提升系统展示效果,对消息缓冲与插值延迟、特效集成与驱动机制、相机管理和场景切换等关键技术提出了优化设计方案,使之更加适应航天器可视化展示需求。设计系统较传统可视化系统展示更为流畅,场景视角切换更为智能。系统已应用于多个航天器研发工作中,应用效果证明系统具有良好的通用性和实用性,具有一定的推广价值。