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91.
A series of four novel hydrazine-modified diamine conjugates (7a-b, 8a-b) were synthesized and evaluated for cytotoxicity against Melanoma B 16, α-difluoromethylornithine (DFMO)-treated B 16, spermidine (SPD)-treated B 16, Mouse leukemia L 1210 and Hela cell lines. Both the DFMO-B 16 and SPD-B 16 experiments indicated that conjugates 7a-b and 8a-b could recognize the polyamine transporter (PAT) and enter the cells in part or in whole via PAT, although they were not as efficient as the reference, 9- anthracenemethyl homospermidine (1). 2007 Chao Jie Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 相似文献
92.
本文研究了带有Radon-Nikodym导数的算子值自由Fisher信息量.利用模框架理论,得到了一个半圆元和一个子代数之间的合并自由关系,推广了D.Voiculescu等人的工作. 相似文献
93.
P. P. J. Van Den Bosch F. A. Lootsma 《Journal of Optimization Theory and Applications》1987,55(2):313-326
We investigate methods for solving high-dimensional nonlinear optimization problems which typically occur in the daily scheduling of electricity production: problems with a nonlinear, separable cost function, lower and upper bounds on the variables, and an equality constraint to satisfy the demand. If the cost function is quadratic, we use a modified Lagrange multiplier technique. For a nonquadratic cost function (a penalty function combining the original cost function and certain fuel constraints, so that it is generally not separable), we compare the performance of the gradient-projection method and the reduced-gradient method, both with conjugate search directions within facets of the feasible set. Numerical examples at the end of the paper demonstrate the effectiveness of the gradient-projection method to solve problems with hundreds of variables by exploitation of the special structure. 相似文献
94.
95.
The stationary and nonstationary rotating Navier-Stokes equations with mixed boundary conditions are investigated in this paper. The existence and uniqueness of the solutions are obtained by the Galerkin approximation method. Next, θ-scheme of operator splitting algorithm is applied to rotating Navier-Stokes equations and two subproblems are derived. Finally, the computational algorithms for these subproblems are provided. 相似文献
96.
A.H. Bentbib 《Numerical Algorithms》1999,21(1-4):79-86
We propose the interval version of the conjugate directions method, to solve the problem of linear systems, with symmetric
and positive definite interval matrix A, and a right-hand side interval vector b.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
97.
98.
This paper describes a coupling framework for parallel execution of different solvers for multi-physics and multi-domain simulations with an arbitrary number of adjacent zones connected by different physical or overlapping interfaces. The coupling architecture is based on the execution of several instances of the same coupling code and relies on the use of smart edges (i.e., separate processes) dedicated to managing the exchange of information between two adjacent regions. The collection of solvers and coupling sessions forms a flexible and modular system, where the data exchange is handled by independent servers that are dedicated to a single interface connecting two solvers’ sessions. Accuracy and performance of the strategy is considered for turbomachinery applications involving Conjugate Heat Transfer (CHT) analysis and Sliding Plane (SP) interfaces. 相似文献
99.
Coumarin-based urea and urea–amide scaffolds 1–3 have been designed and synthesized for the selective and naked eye detection of cyanide ion. Of the three, compound 3 exhibits ratiometric fluorescence change selectively in the presence of CN? and validates the rationality in designing anion receptor. Upon interaction with CN?, the color of the solution of 3 in CH3CN under UV exposure becomes bright yellow, which is beneficial for its naked eye detection. Addition of CN? of ~10?4 M brings nice color change from colourless to yellow in ordinary light. The sensing event is supposed to be due to nucleophilic addition of CN? to the coumarin unit enabling intramolecular charge transfer (ICT) mechanism. 相似文献
100.
共轭梯度法是最优化中最常用的方法之一,广泛地应用于求解大规模优化问题,其中参数β_k的不同选取可以构成不同的共轭梯度法.给出了一类含有三个参数的共轭梯度算法,这种算法能够在给定的条件下证明选定的β_k在每一步都能产生一个下降方向,同时在强Wolfe线搜索下,这种算法具有全局收敛性. 相似文献