考虑区间数概率分布的技术创新项目综合评价

本文针对目前现状的调查,引入考虑区间数概率分布的思想,综合熵权对技术创新项目进行综合评价,从而达到了更加充分、科学的利用评价信息的目的。     

多元统计分析在课堂教学质量评价元中的应用

为了确保课堂教学质量评价体系的科学性,我们必须对它进行元评价,在元评价过程中,使用α法计算评价的信度,用因子分析评价的效度,是检验评价体系可信和有效程度的重要方法。     

应用MATLAB统计工具箱进行教学评价

根据某学院教务部门提供的教学评价数据,利用MATLAB统计工具箱的多元统计回归命令和逐步回归命令,建立了学生对教师总体评价与各评价项目之间的四个回归模型.这些模型简单有效且逐步改进,由此能给教师提供一些合理的建议,以提高教学质量.     

面向对象的高分辨率遥感影像分割精度评价方法

在参考监督评价法原理的基础上,提出了三个高分辨率遥感影像分割精度评价指标：准确度、查全率和相对相似性,并以此为基础提出了遥感影像分割精度的评价方法。针对监督评价法的参考对象匹配问题,提出了一种双向局部最优对象匹配方法。同时,通过安徽省淮南市高分一号遥感影像分割结果的精度评价,进行了实验验证。结果表明：该评价指标能够较好地反映分割结果的优劣,符合地物对象分割的真实分布;还可为遥感影像分割算法的参数设置和多尺度分割的最优尺度选择提供依据。     

激光LCOS光学引擎的设计

通过选择适当的光学材料,并且将它们合理地安排在一起,设计完成了激光LCOS投影机的光学引擎。光学组件包含3块LCOS面板和三基色的激光光源。在光学设计中使用光学软件ZEMAX对光学引擎进行了优化。设计的光学引擎证实了激光LCOS显示的高效率和均匀性,并且所有指标都满足激光LCOS显示的要求。     

基于微流控技术平台的Pt基三元电催化剂高通量合成和筛选（英文）

高性能铂基电催化剂的高效合成和筛选对于加速其在各个领域的进一步发展和应用具有重要意义。微流控高通量技术在铂基电催化剂的合成参数优化应用方面具有巨大的潜力。然而,缺少性能评估的微流控高通量合成无法最大限度地发挥其优势。在这项工作中,我们构建了将材料的高通量合成与高通量筛选相结合的多功能平台。该平台的微流控芯片可以生成三种不同前驱体金属离子的20级浓度梯度。微反应器阵列具有100个微通道,用于材料合成和电化学表征。利用该平台我们合成了5组铂基三元电催化剂(共计100种不同的组分),并进行了电化学表征,直接确定了Pt基三元电催化剂对析氧反应的最佳组成。这表明我们所构建微流控高通量平台具有高效性和灵活性,可大大缩短了新材料开发和材料性能优化的周期。     

Englerin A的全合成及其类似物生物活性的研究进展

Englerin A是一种从大戟属植物Phyllanthus engleri中分离得到的含有氧桥结构的愈创木烷类倍半萜,对肾癌细胞表现出很高的抑制活性和选择性.综述了englerin A的全合成及其初步构效关系的研究进展.在合成部分,对各个合成路线的特点,尤其对氧杂三环骨架的构建过程进行了重点讨论.     

Characterization of a biopharmaceutical protein and evaluation of its purification process using automated capillary Western blot

This paper describes the application of an automated size‐based capillary Western blot system (Sally instrument) from ProteinSimple, Inc., for biopharmaceutical fusion‐Fc protein characterization and evaluation of its purification process. The fusion‐Fc protein column purification from an excess of single chain Fc polypeptide and removal of an enzyme coexpressed for protein maturation have been demonstrated using an automated capillary Western system. The clearance of a selected host cell protein (HCP) present in cell culture of fusion‐Fc protein was also quantitatively monitored throughout the protein purification process. Additionally, the low levels of fusion‐Fc product‐related impurities detected by traditional slab gel Western blot were confirmed by the automated capillary Western system. Compared to the manual approach, the automated capillary Western blot provides the advantages of ease of operation, higher sample throughput, greater linearity range, and higher precision for protein quantitation.     

Stability evaluation of tramadol enantiomers using a chiral stability-indicating capillary electrophoresis method and its application to pharmaceutical analysis

In this study, a chiral stability-indicating CE assay was developed for the stability evaluation of tramadol (TR) enantiomers in commercial tablets using maltodextrin as chiral selector. To investigate the stability-indicating power of the analytical method as well as stability evaluation of TR enantiomers, active pharmaceutical ingredient and TR tablets were subjected to photolysis, heat, oxidation and hydrolysis to conduct stress testing. Best separation for the TR enantiomers was achieved on an uncoated fused-silica capillary at 20 °C using borate buffer (50 mM, pH 10.2) containing 10% m/v maltodextrin. All determinations were performed by a UV detector at 214 nm. A constant voltage of 20 kV was applied to obtain the separation. The range of quantitation for both enantiomers was 5-100 μg/mL (R>0.996). Intra- and inter-day RSD (n=6) were less than 10%. The percent relevant errors were obtained to be less than 4.0 for both enantiomers. The limits of quantitation and detection for both enantiomers were 5 and 1.5 μg/mL, respectively. Degradation products resulting from the stress studies were the same for both enantiomers and did not interfere with the detection of the enantiomers.     

土壤重金属污染评价指标的研究进展

土壤重金属污染评价指标主要有：土壤重金属总含量，有效含量，土壤酶活性以及植物中毒临界含量等。由于受重金属污染的土壤中往往伴有多种重金属元素以及元素之间的交互作用，使得临界值的确定更为复杂，目前评价土壤重金属复合污染的方法主要是综合指数法。