浓缩当归丸及当归片的HPLC指纹图谱质量初步评价

应用当归药材HPLC指纹图谱技术并结合共有峰相似度、主成分分析(PCA)、聚类分析(HCA)等化学计量学手段,对部分市售当归单味药成方制剂——浓缩当归丸和当归片进行了质量一致性和稳定性,以及与当归药材相关性的初步评价。研究结果表明,浓缩当归丸与当归片之间因制备工艺不同,其化学物质的组成与含量具有明显的差异;不同厂家生产的同类药品具有比较一致的整体色谱形貌,浓缩当归丸与当归药材图谱的相似度略高于当归片,当归片的质量稳定性和一致性略优于浓缩当归丸;同厂家不同批次同种药品的质量差异较小。此外,通过浓缩当归丸和当归片与当归药材色谱指纹图谱的对比分析,进一步探究了当归药材色谱指纹图谱中可能的药效物质信息。     

新型胰岛素增敏剂的合成及其生物活性评价

以川芎嗪为结构单元,与噻唑烷二酮类降糖药物的药效团组合,设计并合成了一个新的胰岛素增敏剂——2-甲氧基-5-[(2,4-二氧代-5-噻唑烷基)-甲基]-N-[(3,5,6-三甲基-2-吡嗪基)-甲基]-苯甲酰胺(Ⅰ),其结构经1H NMR和MS表征。体外活性测试结果表明,Ⅰ在用药量为1×10-5mol·L-1时对PPAR-γ的激动活性与吡格列酮相当;体内生物活性测试结果表明,Ⅰ有抑制血糖升高的倾向,有一定的血管内皮细胞保护作用。     

Synthesis,characterization and anticancer evaluation of 2-(naphthalen-1-ylmethyl/naphthalen-2-yloxymethyl)-1-[5-(substituted phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-1H-benzimidazole

In the present study o-phenylenediamine and naphtene-1-acetic acid/2-naphthoxyacetic acid were used as a starting material through a series of steps and 2-(naphthalen-1-ylmethyl/Naphthalen-2-yloxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5a, 5b were obtained. In the first series 1,3,4-oxadiazole derivatives have been synthesized from Schiff base of the corresponding hydrazide i.e. 2-[2-(naphthalen-1-ylmethyl)-1H-benzimidazol-1-yl]acetohydrazide 5a by using Chloramin-T. In the second series 1,3,4-oxadiazole has been synthesized from 2-{2-[(naphthalen-2-yloxy)methyl]-1Hbenzimidazol-1-yl}acetohydrazide 5b by using phosphorous oxychloride and aromatic acid. These compounds were evaluated by IR, NMR, Mass spectrometry, elemental analysis and finally in vitro anticancer evaluation was carried out by NCI 60 Cell screen at a single high dose (10–5 M) on various panel/cell lines. One compound 7c was found to be the most active on breast cancer cell line and compounds 4b and 7d were moderately active.     

水资源配置方案综合评价中的信息损失测度研究

水资源配置的多属性特征使得在方案综合评价中依据不同的聚合方法,能够获得不完全一致的方案排序结果。本文从水资源配置方案评价的决策矩阵及方案排序结果中的信息量大小入手,利用信息熵理论和斯皮尔曼等级相关系数提出衡量水资源配置方案综合评价中信息损失的香农斯皮尔曼测度。并构造由2种权重(熵权法权重、证据理论权重)与3种评价模型(简单加权法、模糊优选法、TOPSIS)组合而成的6种综合评价模型。最后,将香农斯皮尔曼测度运用到天津市水资源配置方案综合评价过程中的信息损失的衡量,并与文献中的综合评价模型所得结果进行比较。结果表明,采用证据理论权重-模糊优选评价模型所得评价结果的绝对信息损失和相对信息损失最小。通过水资源配置方案综合评价中的信息损失测度研究,能够使得水资源配置方案综合评价过程更加透明,并为决策部门选取理想的水资源配置方案综合评价方法提供决策支持。     

ADS系统中少系核素的灵敏度分析

为了确定加速器驱动系统中少系核素的核数据的不确定性对此系统中积分参数的影响,选择一铅 铋冷却次临界系统来进行分析,选择不同的微观评价库CENDL 3.0,JENDL 3.2及ENDF/B VI.6,并只考虑20MeV以下的中子产额,来计算次临界系统的积分参数.以ENDF/B VI.2库的计算结果作为参考结果,依次用CENDL 3.0库及JENDL 3.2库中相应的系核素替换ENDF/B VI.6库中的系核素,计算了次临界系统的Keff值及反应率,并就变换主要系核素时对所计算的Keff值及反应率的影响进行了分析、比对.在堆芯处,当改变系核素时Keff值总的变化为30%,CENDL 3.0的238Pu的弹性散射反应率比ENDF/B VI库的结果高出10%,ENDF/B VI库的242Am的裂变率超过了CENDL 3.0库的15%.     

On the generalized Ball bases

The Ball basis was introduced for cubic polynomials by Ball, and two different generalizations for higher degree m polynomials have been called the Said–Ball and the Wang–Ball basis, respectively. In this paper, we analyze some shape preserving and stability properties of these bases. We prove that the Wang–Ball basis is strictly monotonicity preserving for all m. However, it is not geometrically convexity preserving and is not totally positive for m>3, in contrast with the Said–Ball basis. We prove that the Said–Ball basis is better conditioned than the Wang–Ball basis and we include a stable conversion between both generalized Ball bases. The Wang–Ball basis has an evaluation algorithm with linear complexity. We perform an error analysis of the evaluation algorithms of both bases and compare them with other algorithms for polynomial evaluation.     

基于演化算法的大学生综合素质评价系统

大学生综合评价系统包括德、智、体、美、劳等多方面的内容.本系统结合中国地质大学学生的具体情况从德育素质、专业素质、身体素质、发展性素质、心理素质等方面对大学生综合素质进行合理的评价.为了能更有效地体现学生综合素质,我们采用演化算法确定指标权重,提高指标权重的客观性,提供了更合理的测评标准.     

单纯形优化高效液相色谱分离混合酚与吡嗪烷基化产物的研究

本文详细地研究了用改进单纯形与加权形心单纯形优化高效液相色谱法分离苯酚、邻-苯二酚、对-苯二酚、邻-甲基苯酚、邻-硝基苯酚与α-萘酚混合物及吡嗪烷基化产物的条件,讨论了各种参数对优化分离的影响,提出了一个优化综合评价指标,建立了混合酚及吡嗪烷基化产物的分离方法。     

基于AHP-灰色聚类分析的高新技术成果综合转化价值评价

高新技术成果综合转化价值的测度同时受到实施企业经营绩效、项目管理团队运营能力、项目技术经济可行性分析、项目转化综合风险等四个层面因素的影响，如何整体衡量这些制约因素导致项目综合转化价值的消长，对于优选高新技术转化项目予以实施是至关重要的，本文建立基于AHP-灰色定权聚类分析方法的评价模型，收集数据开展实证分析，演示评价方法的操作流程，同时借助简要蛛网模型分解剖析高新技术成果的转化价值并提供优化策略。     

Spatiotemporally inhomogeneous plastic flow of a bulk-metallic glass

With geometrically-constrained specimens, the spatiotemporally inhomogeneous deformation of a Zr-based bulk-metallic glass in uniaxial, quasistatic, compression was investigated. Decreasing the height/width ratio of specimens from 2 to 0.5 significantly increases the plastic strain from 2% to about 80%. Using an infrared camera, we first observe in situ dynamic shear-banding operations during compression at various strain rates. The shear banding is highly dependent on strain rates, either intermittent at the lower strain rate or successive at the higher strain rate. Scanning electron microscopy observations show the spatiality of the rate-dependent shear banding. The serrated plastic flow is a result of the shear-banding operations. At the lower strain rate, more simultaneous shear-banding operations result in more obvious serrations, while at the higher strain rate, fewer simultaneous shear-banding operations cause less obvious serrations.