Quantitative determination of sodium stearyl fumarate in a tablet formulation from continuous manufacturing using a high-pH reversed-phase HPLC method

This study demonstrates the first use of a reversed-phase (RP) high-performance liquid chromatography method with a high-pH buffer for the analysis of sodium stearyl fumarate (SSF) from a tablet formulation. After examining the retention time and peak shape using various buffer concentrations, buffer pH, and RP stationary phases, an optimized method was established using the XBridge® BEH C18 at high pH. This column was further evaluated for method specificity, accuracy, precision, linearity, stability, and sensitivity. Finally, the method was successfully used as a convenient and robust analytical procedure to accurately quantitate SSF in stratified tablets from a continuous manufacturing process to confirm the excipient uniformity throughout the process.     

Bioprinting of Collagen: Considerations,Potentials, and Applications

Collagen is the most abundant extracellular matrix protein that is widely used in tissue engineering (TE). There is little research done on printing pure collagen. To understand the bottlenecks in printing pure collagen, it is imperative to understand collagen from a bottom‐up approach. Here it is aimed to provide a comprehensive overview of collagen printing, where collagen assembly in vivo and the various sources of collagen available for TE application are first understood. Next, the current printing technologies and strategy for printing collagen‐based materials are highlighted. Considerations and key challenges faced in collagen printing are identified. Finally, the key research areas that would enhance the functionality of printed collagen are presented.     

A new mathematical model towards the integration of cell formation with operator assignment and inter-cell layout problems in a dynamic environment

This paper proposes a new mathematical model to solve the cell formation, operator assignment and inter-cell layout problems, simultaneously. The objectives of proposed model are minimization of inter–intra cell part trips, machine relocation cost and operator related issues. Since the objective function of the proposed model consists of none commensurable statements, the preferred solution is obtained by the LP-metric approach. In order to validate the proposed model, some numerical examples are generated randomly and solved by branch and bound technique. Moreover; a real case study is illustrated in order to verify its applicability in an automobile producer company. Moreover the sensitivity analysis of proposed model shows that considering the operator assignment problem has significant impact on the overall system efficiency.     

云计算在RSA密码体制分析中的应用

RSA是著名的公钥密码体制之一,其安全性是基于大整数因子分解困难性假设的,求解RSA问题的最直接方法是分解RSA的模数.由于云计算的大规模分布式计算能力,一些使用分布式计算模型MapReduce的大整数分解手段已经实现,针对大整数因子分解的问题,提出了给定范围内搜索因子的新方法,并对相应的实验数据和结果进行了分析.结果表明,在云中的分布式计算的运行时间远小于单台机器.     

面向不确定需求租户集的云服务智能匹配模型

为了解决云计算环境下由海量租户集和资源集间的不确定性因素引起的高质量云服务获取困难的问题,提出了一种描述动态异构租户集不确定性需求的方法.在此基础上,构建属性权重完全未知情况下的云服务智能匹配模型,排除了租户提交权值造成的偏差.神经网络以属性区间计算的相离度作为输入,服务满意度为输出来动态模拟租户集的不确定需求,运用萤火虫算法求解模型获取最优服务组合.最后,实例验证了神经网络的可靠性以及算法的有效性.实验结果表明,模型能有效获取高质量的云服务组合,优于传统的匹配方法.     

AaaS:Agent云平台研究与实现

云计算是一种通过互联网将各种资源按照一定的方法整合在一起,以服务的形式向外提供的商业模式,有着良好的发展前景.Agent技术拥有其他技术无法比拟的智能性,并在各个领域都得到了广泛的应用.但Agent软件的系统开发、部署、运行以及维护仍采用传统的技术方案,无论在硬件还是软件设施上都存在着严重的浪费,因此将云计算与Agent技术结合起来,建立基于云计算的Agent平台(AaaS),来解决上述存在的问题,利用虚拟化技术解决硬件资源的浪费,设计开发Agent开发工具箱(ADT)以统一的标准来开发和部署Agent,提供云控制器来实时监测Agent的运行状态,进而动态的解决Agent运行时存在的问题.     

A new design of the elimination and choice translating reality method for multi-criteria group decision-making in an intuitionistic fuzzy environment

The purpose of this paper is to design a new extension of the ELECTRE, known as the elimination and choice translating reality method, for multi-criteria group decision-making problems based on intuitionistic fuzzy sets. This method is widely utilized when a set of alternatives should be identified and evaluated with respect to a set of conflicting criteria by reflecting decision makers’ (DMs’) preferences. However, handling the exact data and numerical measure is difficult to be precisely focused because the DMs’ judgments are often vague in real-life decision problems and applications. A more realistic and practical approach can be to use linguistic variables expressed in intuitionistic fuzzy numbers instead of numerical data to model DMs’ judgments and to describe the inputs in the ELECTRE method. The proposed intuitionsitic fuzzy ELECTRE utilizes the truth-membership function and non-truth-membership function to indicate the degrees of satisfiability and non-satisfiability of each alternative with respect to each criterion and the relative importance of each criterion, respectively. Then, a new discordance intuitionistic index is introduced, which is extended from the concept of the fuzzy distance measure. Outranking relations are defined by pairwise comparisons and a decision graph is depicted to determine which alternative is preferable, incomparable or indifferent in the intuitionistic fuzzy environment. Finally, a comprehensive sensitivity analysis is employed to further study regarding the impact of threshold values on the final evaluation, and a comparative analysis is demonstrated with an application example in flexible manufacturing systems between the proposed ELECTRE method and the existing intuitionistic fuzzy technique for order preference by similarity to ideal solution (IF-TOPSIS) method.     

多级制造系统的最优化模型及其应用

多级制造系统是现代制造业的主要加工方式，系统的每一级的加工速度和加工周期是系统设计的主要决策变量，正确确定这两个变量是系统得到优化的主要目标。本文导出了系统优化的基本模型，它包括系统各级的生产时间、等待时间、生产速度、生产成本以及系统的循环时间、总成本、产品利润和利润率等，并给出了一个应用实例。     

移动云计算中基于LBS的个性化服务推荐模型

随着智能手机的普及和3G技术的发展,信息呈指数式增长,从海量的信息中提取出用户感兴趣的内容已成为电子商务发展的一个重要趋势,然而传统的推荐策略已不能满足用户的需求.为此,基于移动云计算和位置信息,提出了一个个性化服务推荐模型解决方案,该方案综合了社交网络和时效性,建立了用户兴趣模型库.基于这个解决方案,在Android平台上,实现了初步的个性化图片推荐模型,取得了不错的效果.个性化服务推荐系统具有良好的发展和应用前景,能有效的保留客户,提高电子商务系统的服务能力,带来巨大的效益,具有一定的理论和现实意义.     

基于云模型的三维土工网防护边坡侵蚀稳定性综合评价

在分析各项影响因素分级标准的基础上,建立了三维土工网护坡侵蚀稳定性的综合评价体系.针对三维土工网边坡侵蚀稳定性分析中不确定性问题,将云模型理论引入到综合评判中,实现了定性与定量的不确定性转换.通过构建前件云发生器和后件云发生器,利用不确定推理,确定各项评价指标的具体分值.借助层次分析法与敏感度分析确定各项评价指标的权重,进而得出综合评价体系的整体得分.工程实例计算结果证实了模型的实用性和有效性,为三维土工网防护边坡侵蚀稳定性的评价提供了一条新的途径.