Identifying critical states of hepatocellular carcinoma based on landscape dynamic network biomarkers

Hepatocellular carcinoma (HCC) is the major histological form of primary liver cancer. It has usually reached the disease state once the patient is diagnosed since there are no specific symptoms in the early stages of HCC. This fact increases the difficulty of curing HCC. Recently, quantities of evidence have shown that many mathematical methods (such as dynamic network biomarkers, DNB) can be used to detect critical states or tipping points of complex diseases. However, it is difficult to apply the DNB theory to the clinic since multiple samples are generally unavailable for individual patient. This paper constructs a novel method based on landscape dynamic network biomarkers (L-DNB), which aims to detect early warning signals from cirrhosis state to very advanced HCC state in individual patient. The selected dataset contains multiple samples for each HCC state. A score that indicates the disease characteristics is calculated for each sample by RNA-seq data, and several scores constitute a distribution in the same state. Quantifying the statistical characteristics of these distributions and determining that low-grade dysplastic and high-grade dysplastic are the critical states of HCC. These results can provide scientific advice for early warning indicators and optimal treatment time for HCC.     

Determination and comparison of agarwood from different origins by comprehensive two‐dimensional gas chromatography–quadrupole time‐of‐flight mass spectrometry

Agarwood, a species of resinous heartwood, is a precious medicinal plant and a type of rare natural spice, which is widely used in medicine, cosmetics, religious activities, and other fields. In this study, agarwood samples from eight different regions across four countries were analyzed by comprehensive two‐dimensional gas chromatography?quadrupole time‐of‐flight mass spectrometry. A total of 232 species were identified (the match factors of these compounds were above 750). The main compounds of agarwood are oxygenated sesquiterpenes and chromones. The compositions of India1 and Malaysia2 were significantly different from those of other samples, which might be attributed to the different production processes of agarwood. For further investigation, factor analysis was conducted for six agarwood samples. The results showed that the data classification possessed a regional characteristic; according to the retention time and relative content, characteristic compositions were determined by factor scores. Finally, the differences of characteristic compositions were simply analyzed, and the reasons were speculated.     

冰盘管密度对蓄冷槽取冷特性影响的实验研究

通过构建高密度直接蒸发式冰盘管实验台,研究了不同冰盘管密度对取冷特性的影响。实验结果表明:随着蓄冷槽中冰盘管密度的增大,可使直接蒸发式蓄冰槽取冷水温进一步降低,取冷速率进一步提高,从而能更好地满足低温送风空调系统的要求及空调高峰负荷变化的需要。     

管道超结构轴向带隙特性分析及实验研究

本文提出一种新型管道超结构元胞构型,其轴向振动带隙包括局域共振型和布拉格(Bragg)散射型两种带隙,该结构在2 500 Hz内共有两阶带隙,且第二阶带隙频率范围较宽。分别应用传递矩阵法和有限元法计算了该结构的能带结构分布及有限周期结构传输特性;搭建了包含4个元胞的管道超结构实验平台进行振动测试,并与计算结果进行对比验证;最后讨论了不同参数对其带隙分布的影响规律。结果表明,所研究管道超结构在2 500 Hz内共有两阶带隙,第一阶带隙主要为局域共振型带隙,凸台和振子的几何尺寸对其影响较大,元胞尺寸对其影响较小。第二阶带隙主要为布拉格散射型带隙,带隙宽度可达923 Hz,该带隙分布随元胞长度、凸台长度和振子厚度改变而改变。合理设计结构各部分几何尺寸,可满足工程中特定频段抑振的需求。     

黄绿色葡萄石的矿物学特征及谱学研究

葡萄石可以以板状、片状、葡萄状、肾状、放射状或块状集合体的形式产出,因其美丽的外观和特殊的晶体结构,近年来受到了学者的广泛关注。本文通过电子探针、粉晶X射线衍射仪、傅里叶变换红外光谱仪、显微拉曼光谱仪、紫外可见分光光度计等仪器对黄绿色葡萄石的成分、结构及谱学特征进行了分析与探讨。葡萄石的主要致色元素为Fe,且Fe³⁺经常取代Al³⁺占据八面体配位,Fe²⁺经常取代Ca²⁺存在于空隙中。电子探针数据表明:Fe与Al的含量变化整体呈现负相关关系,Fe与Ca的含量变化也整体呈现负相关关系,Fe含量相对较高的样品其黄绿色调加深。XRD图谱和拉曼光谱的结果表明:在葡萄石中绿帘石以包裹体的形式存在。红外光谱和拉曼光谱表明葡萄石中存在硅氧四面体和铝氧八面体两种架构,紫外可见吸收光谱揭示了葡萄石的致色机理。本文对葡萄石的矿物学特征及谱学特征进行系统分析,为后续葡萄石的进一步研究提供思路与实验数据。     

机械磨抛对CdZnTe薄膜阻变特性的影响

采用磁控溅射法在ITO玻璃上制备了CdZnTe薄膜,探究机械磨抛对CdZnTe薄膜阻变特性的影响。通过对XRD图谱、Raman光谱、AFM显微照片等实验结果分析阐明了机械磨抛影响CdZnTe薄膜阻变特性的物理机制。研究结果表明,磁控溅射制备的薄膜为闪锌矿结构,F43m空间群。机械磨抛提高了CdZnTe薄膜的结晶质量;CdZnTe薄膜粗糙度(Ra)由磨抛前的3.42 nm下降至磨抛后的1.73 nm;磨抛后CdZnTe薄膜透过率和162 cm^-1处的类CdTe声子峰振动峰增强;CdZnTe薄膜的阻变开关比由磨抛前的1.2增加到磨抛后的4.9。机械磨抛提高CdZnTe薄膜质量及阻变特性的原因可能是CdZnTe薄膜在磨抛过程中发生了再结晶。     

抛物面式太阳能聚能系统聚光特性模拟

结合集热器的光学特性,本文应用蒙特卡罗法对理想的槽型和碟型两种抛物面集热器在不同焦距、不同边缘角时焦面上的热流密度进行了计算,获得了焦距、边缘角和聚光比之间的关系。在考虑太阳不平行度、跟踪指向误差、镜面的反射误差条件下,对碟型抛物面太阳能聚能系统的辐射特性进行了数值模拟分析,获得了吸收器壁面热流分布以及边缘角对焦面热流分布的影响,为太阳能聚能系统的设计和安装提供参考依据。     

超声弹性成像参数联合血清MK和VEGF对分化型甲状腺癌的诊断价值及与肿瘤恶性程度关系研究

本研究选取了分化型甲状腺癌(DTC)患者106例为甲状腺癌组,同期106例甲状腺腺瘤患者为甲状腺腺瘤组,检测比较了两组患者的超声弹性成像参数(弹性比值、蓝色面积比值)、血清中期因子(midkine,MK)、血管内皮生长因子(VEGF)水平.研究结果发现,弹性比值、蓝色面积比值、血清MK和VEGF水平与DTC患者淋巴结转...     

液晶光阀的电光色散特性研究

分析液晶光阀(LCLV)的电光色散特性,重点研究扭曲向列型液晶光阀TB3639的电光色散特性。在温度为27 ℃时, 将TB3639液晶光阀置于频率为1 000 Hz的交流电场中,测出电光特性T-λ曲线,同时得到不同波长的T-V电光特性曲线,确定对比度与光波波长的函数关系k(λ),并得出电光色散特性关系曲线k(λ)～λ。分析结果表明, TB3639液晶光阀在可见光区域,具有相对较高的对比度,其色散较小。波长在450～750 nm区域其对比度均大于0.8;其中波长在550～670 nm区域其对比度变化不大,均大于0.95,其色散最小。     

On the Relative Twist Formula of l-adic Sheaves

We propose a conjecture on the relative twist formula of l-adic sheaves, which can be viewed as a generalization of Kato—Saito's conjecture. We verify this conjecture under some transversal assumptions. We also define a relative cohomological characteristic class and prove that its formation is compatible with proper push-forward. A conjectural relation is also given between the relative twist formula and the relative cohomological characteristic class.