Contributions to the synthesis of some ferrocene-containing antibiotics

This Review discusses the synthesis and characterization by our Group of new antibiotics belonging to the class of penicillins, cephalosporins and rifamycins with ferrocenyl and 1, 1′-ferrocenilene residues in the molecule. As reactants for 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA) the following were used: 1, 1-bis(chlorocarbonyl)ferrocene, ferrocenyl sulfochloride, 1, 1′-ferrocenylenedisulfochloride and thioglycolic acids S-modified with ferrocene. In the synthesis of rifamycins, the hydrazides of the thioglycolic acids, S-modified with ferrocene, were employed as nucleophilic agents. The synthesized intermediates were characterized by elemental analysis, TLC, IR, UV and ¹H NMR spectra. The characterization of new antibiotics was made by TLC, IR and UV spectral analysis. Biological activity was tested on Gram-negative and Gram-positive bacteria. Good activity is reported towards Gram-positive bacteria in the case of derivatives containing residues of thioglycolic acid S-modified with ferrocene, the antibacterial activity being similar to that of amoxicillin, carbenicillin and cephalothin. All compounds are inactive towards Gram-negative bacteria.     

The Existence of Periodic Orbits for Higher Dimensional Autonomous Systemswith Small Perturbations

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CONVERGENCE ON RANDOMLY TRIMMED SUMS WITH A DEPENDENT SAMPLE

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Phase dynamics of a detuned single-mode laser

We report measurements on the phase dynamics of a detuned single mode laser which has in the past shown correspondence to the complex Lorenz equation. The corresponding ranges of periodic pulsing, of detuned chaos and of windows within the chaotic domain are investigated.Invited paper     

Formation of lead pyrophosphate glass and the role of anion disproportionation

Thermal, spectroscopic and electrical properties of lead pyrophosphate glass prepared by melt quenching have been examined. A model based on the structural disproportionation of the P₂O ₇ ⁴⁻ ions has been proposed and is shown to consistently explain all the observations. The equilibrium of various anionic species has been discussed on the basis of their electronegativities which are in turn related to their basicities. Communication No. 129 from the Materials Research Centre     

脱镁叶绿素a和脱镁叶绿素b的联合同步荧光分析法

建立了脱镁叶绿素a和脱镁叶绿素b的联合同步荧光分析法。方法简便快速。脱镁叶绿素a和脱镁叶绿素b的线性范围分别为0～400ng/ml和0～200ng/ml,检出限分别为1ng/ml和0.5ng/ml。     

The method of concentrating a substance from a solution in a stationary sorbent layer and its theoretical basis

The principle of concentrating a substance from a mixture flow in a stationary sorbent layer of infinite length that was previously developed for gas chromatography is extended to liquid chromatography. Translated fromIzevestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1063–1065, May, 1997.     

单循环赛赛程安排的一个图论方法

利用图论的边着色理论建立了一个赛程安排的数学模型 .首先建立 n支球队与完全图 Kn的 n个顶点间的一一对应 ,把球队 Ai和 Aj间的比赛关系抽象成 Kn的顶点 i和 j间的边 ( i,j) .然后分别构造出了图K2 m- 1和 K2 m的正常 2 m-1边着色 .从而给出了各球队每两场比赛间得到的休整时间最均等 ,休整的间隔场次数达到上限值 n2 的一个赛程安排方案     

The solution existence of general variational inclusion problems

We propose general variational inclusion problems which are slightly different from corresponding problems considered in several recent papers in the literature and show that they are advantageous. Sufficient conditions for the solution existence are established. As applications we derive consequences for several special cases of variational inclusion problems, quasioptimization problems, equilibrium problems and implicit variational inequalities and show that they improve the results of some recent existing papers.