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291.
292.
Dr. Alexandre Lumbroso Dr. Michael L. Cooke Prof. Dr. Bernhard Breit 《Angewandte Chemie (International ed. in English)》2013,52(7):1890-1932
Allylic alcohols represent an important and highly versatile class of chiral building blocks for organic synthesis. This Review summarizes the plethora of methods developed for the catalytic asymmetric synthesis of enantioenriched allylic alcohols. These include: dynamic kinetic resolution (DKR/DKAT), nucleophilic 1,2‐addition to carbonyl groups, allylic substitution, oxidation of C? H bonds, the addition of O nucleophiles to π systems, reduction of unsaturated carbonyl compounds, and an alternative route from enantioenriched propargylic alcohols. Furthermore, these catalytic asymmetric processes are exemplified by their applications in the syntheses of complex molecules such as natural products and potential therapeutic agents. 相似文献
293.
Dr. Naoya Kumagai Prof. Dr. Masakatsu Shibasaki 《Angewandte Chemie (International ed. in English)》2013,52(1):223-234
A series of asymmetric catalysts composed of conformationally flexible amide‐based chiral ligands and rare‐earth metals was developed for proton‐transfer catalysis. These ligands derived from amino acids provide an intriguing chiral platform for the formation of asymmetric catalysts upon complexation with rare‐earth metals. The scope of this arsenal of catalysts was further broadened by the development of heterobimetallic catalytic systems. The cooperative function of hydrogen bonding and metal coordination resulted in intriguing substrate specificity and stereocontrol, and the dynamic nature of the catalysts led to a switch of their function. Herein, we summarize our recent exploration of this class of catalysts. 相似文献
294.
295.
Andrew J. Bissette Dr. Stephen P. Fletcher 《Angewandte Chemie (International ed. in English)》2013,52(49):12800-12826
Self‐replication is a fundamental concept. The idea of an entity that can repeatedly create more of itself has captured the imagination of many thinkers from von Neumann to Vonnegut. Beyond the sciences and science fiction, autocatalysis has found currency in economics and language theory, and has raised ethical fears memorably summed up by the “gray goo” trope. Autocatalysis is central to the propagation of life and intrinsic to many other biological processes. This includes the modern conception of evolution, which has radically altered humanity’s image of itself. Organisms can be thought of as imperfect self‐replicators which produce closely‐related species, allowing for selection and evolution. Hence, any consideration of self‐replication raises one of the most profound questions of all: what is life? Minimal self‐replicating systems have been studied with the aim of understanding the principles underlying living systems, allowing us to refine our concepts of biological fitness and chemical stability, self‐organization and emergence, and ultimately to discover how chemistry may become biology. 相似文献
296.
Dr. Seiji Shirakawa Prof. Dr. Keiji Maruoka 《Angewandte Chemie (International ed. in English)》2013,52(16):4312-4348
Phase‐transfer catalysis has been recognized as a powerful method for establishing practical protocols for organic synthesis, because it offers several advantages, such as operational simplicity, mild reaction conditions, suitability for large‐scale synthesis, and the environmentally benign nature of the reaction system. Since the pioneering studies on highly enantioselective alkylations promoted by chiral phase‐transfer catalysts, this research field has served as an attractive area for the pursuit of “green” sustainable chemistry. A wide variety of asymmetric transformations catalyzed by chiral onium salts and crown ethers have been developed for the synthesis of valuable organic compounds in the past several decades, especially in recent years. 相似文献
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298.
This article is a brief overview of the emerging microfluidic systems called surface‐tension‐confined microfluidic (STCM) devices. STCM devices utilize surface energy that can control the movement of fluid droplets. Unlike conventional poly(dimethylsiloxane)‐based microfluidics which confine the movement of fluids by three‐dimensional (3D) microchannels, STCM systems provide two‐dimensional (2D) platforms for microfluidics. A variety of STCM devices have been prepared by various micro‐/nanofabrication strategies. Advantages of STCM devices over conventional microfluidics are significant reduction of energy consumption during device operation, facile introduction of fluids onto 2D microchannels without the use of a micropump, increased flow rate in a special type of STCM device, among others. Thus, STCM devices can be excellent alternatives for certain areas in microfluidics. In this Minireview, fabrication methods, operating modes, and applications of STCM devices are introduced. 相似文献
299.
Yongqiang Zhang ShengzhengWang Zhenyuan Miao Jianzhong Yao Wannian Zhang Chunquan Sheng 《中国化学》2013,(9):1139-1143
Iodiconazole is a novel antifungal agent that was developed in its racemic form. In order to investigate the ef- fects of the chiral center on the antifungal activity, R- and S-isomers of iodiconazole were prepared on the basis of the asymmetric Sharpless epoxidation. (S)-Iodiconazole was proved to have better antifungal activity than the (R)- isomer. The binding modes of the two isomers with lanosterol 14~z-demethylase were clarified by molecular dock- ing. 相似文献
300.
A series of novel axially chiral 2,2′‐bipyridine N,N′‐dioxides bearing C1 or C2‐symmetry have been synthesized by the use of enantiopure α‐amino acids as chiral sources. The absolute stereochemistry of the axial chirality of these organocatalysts has been clearly assigned by means of CD measurements together with literature protocols. The reactivities and enantioselectivities of these organocatalysts have been examined in the reactions of aromatic aldehydes with allyltrichlorosilane, thus providing the desired products with moderate yields and enantioselectivies. 相似文献