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101.
Efficient Separation of Hydrophobic Molecules by Molecularly Imprinted Cyclodextrin Polymers 总被引:2,自引:0,他引:2
Hiroyuki Asanuma Takayuki Hishiya Makoto Komiyama 《Journal of inclusion phenomena and macrocyclic chemistry》2004,50(1-2):51-55
Cyclodextrins were cross-linked with toluene 2,4-diisocyanate in dimethyl sufoxide in the presence of hydrophobic biomolecules as templates, and the imprinted polymers were applied to the stationary phases of high performance liquid chromatography. Molecular imprinting efficiently promoted the binding-affinity and substrate-selectivity towards the template molecule, compared with the control polymers prepared in their absence. When cholesterol (template molecule) was complexed with cyclodextrins prior to the polymerization, for example, the imprinted polymer retained cholesterol more strongly than other steroids. Upon the polymerization without a template molecule, the binding towards steroids was much weaker. Besides steroids, imprinting was effective for various hydrophobic and rigid template molecules. Since binding of the guest molecule was based on inclusion complex formation with cyclodextrins, separation could be achieved in the solvents containing water. These polymeric receptors are also applicable to selective recognition of biologically important molecules or removal of toxic molecules from aqueous media. Thus, imprinting of cyclodextrins is useful for the preparation of synthetic tailor-made receptors for various kinds of hydrophobic guest molecules. 相似文献
102.
Uniform-sized molecularly imprinted polymer (MIP) beads were prepared using a one-step swelling and polymerization method. The obtained sulfamethazine (SMZ)-imprinted polymer showed high affinity and selectivity toward SMZ and other structurally related sulfonamides in acetonitrile or water-acetonitrile mobile phases, particularly in high aqueous systems. The column performance of the MIPs for SMZ and its analogues could be improved by elevating the column temperature and optimizing the flow rate. The hydrogen-bonding effect plays a significant role in the recognition process of SMZ-imprinted polymer systems in organic media, while the ion-exchange effect, as well as hydrophobic effect, dominates the retention mechanism in aqueous-rich media, in addition to shape recognition. 相似文献
103.
104.
Summary The theory of the evaporation of the liquid stationary phase is elaborated and experimentally verified. On the basis of this theory the role played by the losses in the amount of liquid phase present is quantitatively determined. General techniques are examined which minimize the losses; these techniques are based on saturating the incoming carrier gas with liquid phase vapours and raising the pressure of the carrier gas in the column, e.g. by connecting a capillary to the column outlet in order to offer resistance to the gas flow. The application of these techniques ensures stable performance of the gas chromatographic columns using a volatile liquid phase. 相似文献
105.
以3-脲丙基三甲氧基硅烷为偶联剂,制备了一种新型极性脲丙基-C30(TPU-C30)反相色谱固定相。采用扫描电子显微镜、元素分析、红外光谱和热分析等对该固定相进行表征。结果表明,TPU-C30固定相已成功制备,连续制备3次固定相,其元素含量的相对偏差均小于5%,说明该合成工艺重复性良好。以不同极性、位置异构、碱性化合物为溶质探针,以传统的C18色谱柱与C30色谱柱为参比,对制备的固定相的色谱性能进行了研究。研究结果表明,TPU-C30固定相具有不同于传统C18柱、C30柱的选择性和更优的择形性,明显改善了碱性物质的峰形,其具有广阔的应用空间。 相似文献
106.
Summary The paper discusses the effect of the length and structure of the hydrocarbon chain connecting the nitrile group to the silica gel surface on the chromatographic properties of cyanoalkyl phases.When using non-polar and polar mobile phases, the selectivity of the cyanodecyl phases toward PAHs is higher than of the cyanopropyl phase and of hydroxylated silica gel.Polar additives to the mobile phase drastically decrease the retention on silica gel and on the cyanopropyl phase while affect the properties of cyanodecyl phases only to a considerably less degree. Newly synthesized phases with different structures of the hydrocarbon chain are compared with the commerical cyano-and ODS-phases. The retention mechanism on the cyanoalkyl phases is discussed. 相似文献
107.
在反相和正相色谱模式下,研究了几种嘌呤衍生物在葫芦[6]脲单轮烷键合硅胶固定相上的高效液相色谱行为,并在反相模式下与ODS固定相进行了比较,考察了流动相中甲醇含量、流动相pH值和离子强度对嘌呤化合物保留的影响。研究结果表明:在反相模式下,嘌呤化合物与葫芦[6]脲单轮烷键合相之间存在多种相互作用,除疏水作用外,分离过程中还存在与ODS不同的色谱分离机制。在正相条件下,多作用力的色谱分离机制同样存在。葫芦[6]脲单轮烷键合相与溶质之间存在疏水、氢键、π-π和偶极-偶极等多种作用力,协同作用提高了固定相对嘌呤化合物的分离选择性。 相似文献
108.
Liquid chromatographic comparisons for enantiomer resolution of α-amino acids and chiral primary amino compounds were made using chiral stationary phases (CSPs) prepared by covalently bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) of the same chiral selector. The resolution of all α-amino acids on CSP 1 developed in our group was found to be better than that on CSP 2 reported by Machida et al. All α-amino acids examined in this study were well enantioseparated on CSP 1 (α=1.22–2.47), while four analytes were not resolved or all the other analytes were poorly resolved on CSP 2 than on CSP 1. However, in resolving the primary amino compounds without a carbonyl group, CSP 1 was comparable with CSP 2. Although (+)-18-C-6-TA of the same chiral selector was used to prepare CSP 1 and CSP 2, this study showed that different connecting methods for the CSPs might influence their ability to resolve the analytes depending on their structures related to the chiral recognition mechanism. 相似文献
109.
Peter Scharfenberg 《Theoretical chemistry accounts》1980,58(1):73-79
A simple classification scheme is proposed for critical points, based only on rankr and signatures of the (n,n)-matrixG of harmonic force constants. The determination ofr ands, e.g. by the well-known factorizationG=L
T
gL (L: triangular matrix,g: diagonal matrix), has several theoretical as well as practical (computational) advantages over the inspection of eigenvalues ofG, so far used in quantum chemistry. The eigenvalues are sufficient butnot necessary for a classification whereas rank and signature are the only necessary and sufficient prerequisites for solving the task. For the purpose of presenting a working example, by calculating only a 2×2 torque constant matrix, it is shown that the coplanar ethylbenzene is unstable in the CNDO/2 picture. 相似文献
110.
Ward Whitt 《Queueing Systems》1991,9(3):235-268
A fundamental principle of queueing theory isL=W (Little's law), which states that the time-average or expected time-stationary number of customers in a system is equal to the product of the arrival rate and the customer-average or expected customer-stationary time each customer spends in the system. This principle is now well known and frequently applied. However, in recent years there have been extensions, such as H=G and the continuous, distributional, ordinal and central-limit-theorem versions, which show that theL=W relation, when viewed properly, has much more power than was previously realized. Moreover, connections have been established between H=G and other fundamental relations, such as the rate conservation law and PASTA (Poisson arrivals see time averages), which show that there is a much greater unity in the overall theory than was previously realized. This paper provides a review.This paper is dedicated to the memory of our colleague Professor Peter Franken (1937–1989), who contributed greatly to the subject of this paper and to queueing theory more generally. 相似文献