THE REALIZATION OF MULTIPLIER HILBERT BIMODULE ON BIDUAL SPACE AND TIETZE EXTENSION THEOREM

51. Introduction and PreliminaryThe multiplier bimodule of imprimitive bimodule and its application to coaction systemwere introduced in [if, but it is generally not an imprimitive bimodule as noted in [II by anexample. In this paper, the same concept is introduced for Hilbert bimodules which properlycontain imprimitive bimodules (for example, the same example as above), and we obtainthe realization of multiplier bimodule on a quotient of bidual space and Tietze extensiontheorem similar to t…     

基于单元的子区间摄动有限元方法研究

针对区间相关性导致区间扩张的问题,探讨了区间数之间的相关性并给出了降低区间扩张的子区间摄动方法。文中给出了基于单元的子区间摄动有限元计算公式和子区间划分数目的近似计算公式,同时文中讨论了区间有限元计算精度问题,给出了可提高计算效率的一些措施。对桁架结构和平面应力问题梁结构算例分析结果表明文中方法可以达到一定的计算精度,并且是合理可行的。     

严格集压缩映射和凝聚映射的延拓定理及应用(英文)

应用著名的Dugundji延拓定理和Urysohn引理,将Hilbert空间E中有界闭凸集D上的k-集压缩映射和聚映射延拓到全空间,并给出了其在拓扑度计算方面的应用.     

Actions in the Category of Precrossed Modules in Lie Algebras

For any object L in the category of precrossed modules in Lie algebras PXLie, we construct the object Act(L), which we call the actor of this object. From this construction, we derive the notions of action, center, semidirect product, derivation, commutator, and abelian precrossed module in PXLie. We show that the notion of action is equivalent to the one given in semi-abelian categories, and Act(L) is the split extension classifier for L. In the case of a crossed module in Lie algebras we show how to recover its actor in the category of crossed modules from its actor in the category of precrossed modules.     

织物及织物复合材料本构理论与试验研究进展

织物复合材料具有高的抗损伤性, 各方向的性能优于层合复合材料, 因而引起人们的重视.织物增强复合材料由于其高比强度、易于制造和充分发展的织物技术等优点使其已经广泛用于航空、汽车和运动产品. 由于使用这些材料越来越普遍, 自动化生产替代了手工生产, 用精确的方法模拟材料的变形是必不可少的. 为了精确的反映材料的行为, 那么就需要描述材料力学性质的本构方程,而作为验证本构模型的试验是伴随着本构模型的发展而发展的.本文首先综述了织物及织物复合材料的发展和现状, 接着重点介绍了织物及织物复合材料的本构理论的研究发展, 并对织物及织物复合材料的斜拉伸试验、像框试验等内容进行了介绍. 最后根据织物复合材料的最新进展对其未来的发展趋势进行了展望.      

GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments

Many therapeutic proteins are small in size and are rapidly cleared from circulation. Consequently, half-life extension strategies have emerged to improve pharmacokinetic properties, including fusion or binding to long-lasting serum proteins, chemical modifications with hydrophilic polymers such as PEGylation, or, more recently, fusion to PEG mimetic polypeptides. In the present study, two different PEG mimetic approaches, the GlycoTAIL and the FlexiTAIL, were applied to increase the hydrodynamic radius of antibody fragments of different sizes and valencies, including scFv, diabody, and scFv-EHD2 fusion proteins. The GlycoTAIL and FlexiTAIL sequences of varying lengths are composed of aliphatic and hydrophilic residues, with the GlycoTAIL furthermore comprising N-glycosylation sites. All modified proteins could be produced in a mammalian expression system without reducing stability and antigen binding, and all modified proteins exhibited a prolonged half-life and increased drug disposition in mice. The strongest effects were observed for proteins comprising a FlexiTAIL of 248 residues. Thus, the GlycoTAIL and FlexiTAIL sequences represent a flexible and modular system to improve the pharmacokinetic properties of proteins.     

实模上序的拓展

主要目的是将交换环上序的拓展的结论推广到模上.首次提出了"模的序的拓展"的定义,并得到了模的序可拓展的充要条件.方法是通过取模的局部化以及商模,使环上的模的问题转化到域上来解决.     

High‐molecular‐weight polyisobutylenes (PIBs) and PIB networks from liquid PIBs by thiol‐ene clicking

We report the synthesis of high‐molecular‐weight linear polyisobutylenes (PIBs) and PIB networks from low‐molecular‐weight PIB by thiol‐ene click chemistry. Thus, liquid allyl‐telechelic PIB was reacted with small di‐ and tri‐thiols, and the thiolated intermediates chain‐extended by UV‐ or thermally induced free radical initiation to linear and crosslinked products. PIB networks were also prepared by crosslinking SH‐telechelic PIB with a small triallyl compound. Linear products were characterized by ¹H NMR spectroscopy and GPC, and networks by FTIR spectroscopy, extractables, swelling, and permanent set. The effect of reaction conditions (nature of thiol chain extender, concentration of photo‐ and thermal initiators, UV radiation time, and reagent concentrations) on chain extension and crosslinking was investigated. Under well‐defined conditions high‐molecular‐weight PIBs and tight PIB networks were prepared. Thiol‐ene click chemistry provides novel thiolated PIB derivatives and is a useful strategy for the convenient preparation of high‐molecular‐weight rubbery PIBs and tight PIB networks from low‐molecular‐weight PIB precursors. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019