Mass spectral analysis and imaging of tissue by ToF-SIMS—The role of buckminsterfullerene, C60, primary ions

Recent developments in desorption/ionisation mass spectrometry techniques have made their application to biological analysis a realistic and successful proposition. Developments in primary ion source technology, mainly through the advent of polyatomic ion beams, have meant that the technique of secondary ion mass spectrometry (SIMS) can now access the depths of information required to allow biological imaging to be a viable option.Here the role of the primary ion C₆₀⁺ is assessed with regard to molecular imaging of lipids and pharmaceuticals within tissue sections. High secondary ion yields and low surface damage accumulation are demonstrated on both model and real biological samples, indicating the high secondary ion efficiency afforded to the analyst by this primary ion when compared to other cluster ion beams used in imaging. The newly developed 40 keV C₆₀⁺ ion source allows the beam to be focused such that high resolution imaging is demonstrated on a tissue sample, and the greater yields allow the molecular signal from the drug raclopride to be imaged within tissue section following in vivo dosing.The localisation shown for this drug alludes to issues regarding the chemical environment affecting the ionisation probability of the molecule; the importance of this effect is demonstrated with model systems and the possibility of using laser post-ionisation as a method for reducing this consequence of bio-sample complexity is demonstrated and discussed.     

Finite-dimensional Leavitt path algebras

We classify the directed graphs E for which the Leavitt path algebra L(E) is finite dimensional. In our main results we provide two distinct classes of connected graphs from which, modulo the one-dimensional ideals, all finite-dimensional Leavitt path algebras arise.     

Simultaneous Approximation for Generalized Baskakov-Durrmeyer-Type Operators

The present paper deals with the study of a Durrmeyer-type integral modification of certain modified Baskakov operators. Here we study simultaneous approximation properties for these operators by using the iterative combinations. We obtain an asymptotic formula and an error estimation in terms of higher order modulus of continuity for these operators.      

Classification of real moduli spaces over genus 2 curves

We classify, in terms of simple algebraic equations, the fixed point sets of the moduli space of stable bundles over genus 2 curves with anti-holomorphic involutions.Research supported by SRF of University of Missouri.     

Coupled channel description of O+Nd scattering around the Coulomb barrier using a complex microscopic potential

Angular distributions of elastic scattering and inelastic scattering from 2⁺₁ state are measured for ¹⁶O+^142,144,146Nd systems at several energies in the vicinity of the Coulomb barrier. The angular distributions are systematically analyzed in coupled channel framework. Renormalized double folded real optical and coupling potentials with DDM3Y interaction have been used in the calculation. Relevant nuclear densities needed to generate the potentials are derived from shell model wavefunctions. A truncated shell model calculation has been performed and the calculated energy levels are compared with the experimental ones. To simulate the absorption, a ‘hybrid’ approach is adopted. The contribution to the imaginary potential of couplings to the inelastic channels, other than the 2⁺₁ target excitation channel, is calculated in the Feshbach formalism. This calculated imaginary potential along with a short ranged volume Woods–Saxon potential to simulate the absorption in fusion channel reproduces the angular distributions for ¹⁶O+¹⁴⁶Nd quite well. But for ¹⁶O+^142,144Nd systems additional surface absorption is found to be necessary to fit the angular distribution data. The variations of this additional absorption term with incident energy and the mass of the target are explored.     

Differential operators on Hilbert modular forms

We investigate differential operators and their compatibility with subgroups of SL₂n(R). In particular, we construct Rankin-Cohen brackets for Hilbert modular forms, and more generally, multilinear differential operators on the space of Hilbert modular forms. As an application, we explicitly determine the Rankin-Cohen bracket of a Hilbert-Eisenstein series and an arbitrary Hilbert modular form. We use this result to compute the Petersson inner product of such a bracket and a Hilbert modular cusp form.     

Bidendriform bialgebras, trees, and free quasi-symmetric functions

We introduce bidendriform bialgebras, which are bialgebras such that both product and coproduct can be split into two parts satisfying good compatibilities. For example, the Malvenuto-Reutenauer Hopf algebra and the non-commutative Connes-Kreimer Hopf algebras of planar decorated rooted trees are bidendriform bialgebras. We prove that all connected bidendriform bialgebras are generated by their primitive elements as a dendriform algebra (bidendriform Milnor-Moore theorem) and then is isomorphic to a Connes-Kreimer Hopf algebra. As a corollary, the Hopf algebra of Malvenuto-Reutenauer is isomorphic to the Connes-Kreimer Hopf algebra of planar rooted trees decorated by a certain set. We deduce that the Lie algebra of its primitive elements is free in characteristic zero (G. Duchamp, F. Hivert and J.-Y. Thibon conjecture).     

The tetrahedron algebra and its finite-dimensional irreducible modules

Recently Terwilliger and the present author found a presentation for the three-point sl₂ loop algebra via generators and relations. To obtain this presentation we defined a Lie algebra ? by generators and relations and displayed an isomorphism from ? to the three-point sl₂ loop algebra. In this paper we classify the finite-dimensional irreducible ?-modules.     

Ordered OLPS and CF Nth numerators

Definitions, theorems and examples are established for a general model of Laurent polynomial spaces and ordered orthogonal Laurent polynomial sequences, ordered with respect to ordered bases and orthogonal with respect to inner products ·=L°⊙ decomposed into transition functional ⊙ and strong moment functional, or, more generally, sample functional L couplings. Under this formulation that is shown to subsume those in the existing literature, new fundamental results are produced, including necessary and sufficient conditions for ordered OLPS to be sequences of nth numerators of continued fractions, in contrast to the classical result concerning nth denominators which is shown to hold only in special cases.     

Estimation of intrinsic processes affected by additive fractal noise

Fractal Gaussian models have been widely used to represent the singular behavior of phenomena arising in different applied fields; for example, fractional Brownian motion and fractional Gaussian noise are considered as monofractal models in subsurface hydrology and geophysical studies Mandelbrot [The Fractal Geometry of Nature, Freeman Press, San Francisco, 1982 [13]]. In this paper, we address the problem of least-squares linear estimation of an intrinsic fractal input random field from the observation of an output random field affected by fractal noise (see Angulo et al. [Estimation and filtering of fractional generalised random fields, J. Austral. Math. Soc. A 69 (2000) 1-26 [2]], Ruiz-Medina et al. [Fractional generalized random fields on bounded domains, Stochastic Anal. Appl. 21 (2003a) 465-492], Ruiz-Medina et al. [Fractional-order regularization and wavelet approximation to the inverse estimation problem for random fields, J. Multivariate Anal. 85 (2003b) 192-216]. Conditions on the fractality order of the additive noise are studied to obtain a bounded inversion of the associated Wiener-Hopf equation. A stable solution is then obtained in terms of orthogonal bases of the reproducing kernel Hilbert spaces associated with the random fields involved. Such bases are constructed from orthonormal wavelet bases (see Angulo and Ruiz-Medina [Multiresolution approximation to the stochastic inverse problem, Adv. in Appl. Probab. 31 (1999) 1039-1057], Angulo et al. [Wavelet-based orthogonal expansions of fractional generalized random fields on bounded domains, Theoret. Probab. Math. Stat. (2004), in press]). A simulation study is carried out to illustrate the influence of the fractality orders of the output random field and the fractal additive noise on the stability of the solution derived.