Synthesis,Characterization and Crystal Structure of (PhCH2)2Sn(S2CENt2) and (PhCH2)2Sn(S2CNC4H8)2

Two new dibenzyltin bisditiocarbamates(PhCH2)2 Sn(S2CNEt2)2(1) and (PhCH2)2 Sn(S2CNC4H8)2(2) were synthesized by the reaction of dibenzyltin dichloride with dithiocarbamates and characterized by elemental analysis ,IR,^1H NMR and MS spectra.The crystal structures were determined by X-ray single crystal diffraction analysis.In both complexes,the tin atom is six-coordinated in a distorted octahedral configuration.In the crystals of 1,the molecular packing in unit cell reveals that the two adjacent molecules are symmetrically linked to each other in dimers by two Sn S interactions of 0.3816nm.In the crystals of 2,the molecules are packed in the unit cell in one-dimensional chain structure linked by weaker intermolecular S S conmtacts.     

CALCULUS ON CANTOR TRIADIC SET （I）——DERIVATIVE

For real-valued functions defined on Cantor triadic ,set. a derivative with corresponding formula of Newton-Leihniz‘s type is given In particular, for the self-simltar functions and alter-nately jumping functions defined in this paper, their derivative and exceptional sets are studied ac-curately by using ergodic theory on Е2 and Duffin-Scbaeffer‘s theorem coneerning metric diophan-tine approximation. In addition, Haar basis of L2(Е2) is constructed and Flaar expansion of stan-drd self-similar function is given.     

Estimation of the Mean of a Wiener Sheet

A shifted Wiener sheet is observed above a decreasing curve Γ. By the help of a direct discrete approach and under weaker assumptions than in the paper of Arató [Comput. Math. Appl. 33 (1997), 13–25], an explicit formula is derived for the maximum likelihood estimator of the shift parameter. This estimator is a weighted linear combination of the values at the endpoints of the curve Γ and weighted integrals of the observed process and its normal derivative along the curve Γ. This revised version was published online in June 2006 with corrections to the Cover Date.     

Planck尺度的Hopf代数的Poisson括符

本文讨论拟微分算子象证的Witt乘积与C[x]▲△A.G[p]的乘积之间的关系,得到以下结果：具有Witt乘积的象证类S1.0^m。是具有普通乘积的函数类S1.0^m经过对Hopf代数的乘积量子化得到的,进一步，给出了C[x]▲△h.cC[p]上标准的辫导数的显示表示，并且证明了其上的Poisson括号与经典的具有同一形式．     

Molecular Structure of a Chromatographic Chiral Selector Based on a Terguride Derivative

The structure of (+)1-(3-allylpropyl)-(5R,8S,10R)-N,N-diethyl-N-[6-methylergolin-8-yl]urea, C₂₂H₃₃N₄O (allyl-terguride), has been determined as part of a study on the chiral recognition mechanism of ergot alkaloids when they are used as the chiral stationary phase for the separation of racemic mixtures in liquid chromatographic methods. At the pH of the solution used for the crystallization, the molecules of allyl-terguride are protonated at N(6). All bond distances and angles are in the expected ranges. In the asymmetric unit one hydroxide ion is present. Hydrogen bonds join molecules of allyl-terguride in pairs along the b axis, connecting O(2) of the hydroxide ion to O(1) of one molecule and to N(2) and N(6) of another.     

Microcolumn liquid chromatography with silica gel dynamically modified with a bile acid derivative

Summary Characteristics of silica gel dynamically modified with a bile acid derivative have been investigated in liquid chromatography. 3-[(3-cholamidopropyl) dimethylamonio]-1-propane-sulfonate (CHAPS) is selected as modifier. CHAPS possesses a quaternary ammonium group which can be attached to the silica gel surface by cation exchange. The stationary phase modified with CHAPS has been applied to the separation of 1,1-binaphthyl-2,2-diyl-hydrogen phosphate enantiomers.Dedicated to Professor Leslie S. Ettre on the occasion of his 70th birthday.     

替米沙坦及其类似物的合成和生物活性研究

设计合成了替米沙坦及其类似物, 改进了替米沙坦的合成工艺. 用邻苯二胺与相应的有机羧酸缩合, 所得产物苯并咪唑衍生物与4'-溴甲基联苯-2-甲酸甲酯通过N-烷基化得到相应的目标化合物, 合成了替米沙坦和9种未见文献报道的苯并咪唑联苯化合物, 其结构经¹H NMR, IR, MS和元素分析确证. 用体外动脉环的方法, 研究目标化合物的初步体外抗高血压活性, 试验结果表明其中部分化合物具有一定的抗高血压活性.     

Synthesis of （S）-2-Ethoxy-3-Phenylpropanoic Acid Derivatives and Their Insulin-Sensitizing Activity

A series of （S）-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b, 1d, 1e and 1f exhibited more potent insulin-sensitizing activity than rosiglitazone.     

邻苯二酚衍生物与希土元素的配位反应Ⅱ．铈(Ⅳ)配合物显现颜色机理的探讨

用实验与量化计算对邻苯二酚类衍生物与铈（Ⅵ）生成的配合笺显现颜色的机理进行了探讨，认为是由配体上大π键电子向中心金属离子跃迁所 产生的Ｌ→Ｍ荷移所致。     

Salicylaldehyde and dihydroisobenzofuran derivatives from the marine fungus Zopfiella marina

Two salicylaldehyde derivatives (1 and 2), a hydroxymethylphenol (3), five dihydroisobenzofuran (4–8) derivatives, and a 5-chloro-3-deoxyisoochracinic acid (9), together with a known 3-deoxyisoochracinic acid (10) were isolated from the marine fungus Zopfiella marina BCC 18240 (or NBRC 30420). The structures of these compounds were elucidated by extensive spectroscopic analysis. Compound 1 showed weak antituberculous activity against Mycobacterium tuberculosis H37Ra, and antibacterial activity against Bacillus cereus with MIC values of 25 and 12.5 μg/mL, respectively.