Metal Enhanced Electrochemical Cyclooxygenase‐2 (COX‐2) Sensor for Biological Applications

Pain measurement is commonly required in biomedical and other emergency situations, yet there has been no pain biosensor reported in literature. Conventional approaches for pain measurement relies on Wong‐Baker face diagrams, which are grossly inadequate for situations involving children or unconscious people. We report a label‐free immunosensor for monitoring the pain biomarker cylooxygenase‐2 (COX‐2) in blood. The sensor is based on the concept of metal‐enhanced detection (MED). MED relies on the idea that the immobilization of underpotential deposition (upd) metallic films deposited either as a monolayer or electrostatically held onto a solid gold substrate could significantly amplify bimolecular recognition such as involving antigen‐antibody (Ab‐Ag) interactions. The surface bound Ab‐Ag complex insulates the electrode; causing a decrease in concentration‐dependent redox signals. A linear detection range of (3.64–3640.00)×10^?4 ng/mL was recorded with a detection limit of 0.25×10^?4 ng/mL, which was 4 orders of magnitude lower than that reported for ELISA for the same biomarker. The immunosensor exhibited selectivity of less than 6 % for potential interferents.     

Hybrid artificial neural networks for efficient valuation of real options and financial derivatives

A hybrid valuation methodology is proposed and tested for improving the efficiency of contingent claims pricing by combining Artificial Neural Networks (ANN) and conventional parametric option pricing techniques. With one application on financial derivatives and one on real options the methods superiority is demonstrated. The resulting efficiency is instrumental for real time applications.MSC code: 90-08 Acknowledgements: Both authors are thankful for partial financial support to the HERMES European Center of Excellence on Computational Finance and Economics of the University of Cyprus and a University of Cyprus grant for research in ANNs and Derivatives, and to the anonymous referees for their helpful comments and discussions.     

The real scalar field in extreme RNdS space

The real scalar field equation between the outer black hole horizon and the cosmological horizon is solved in the extreme Reissner-Nordström de Sitter (RNdS) space. We use an accurate approximation, the polynomial approximation, to approximate the tortoise coordinate x(r) in order to get the inverse function r = r(x) and then to solve the wave equation. The case where the two horizons are very close to each other is discussed in detail. We find that the wave function is harmonic only in the very small regions near the horizons, and the amplitude decreases remarkably near the potential peak because of the effect of the potential. Furthermore, it is found that the height of the potential increases as the cosmological constant Λ decreases, and the wave amplitude will decrease more remarkably with less Λ.     

Inheritance of surjectivity for partial differential operators on spaces of real analytic functions

For an open set let A(Ω) be the space of real analytic functions on Ω. Improving our previous results, we prove a new quantitative characterization of the linear partial differential operators P(D) which are surjective on A(Ω). This implies that P(D) is surjective on if P(D) is surjective on A(Ω) for some Ω≠∅. Further inheritance properties for the surjectivity of P(D) on A(Ω) are also obtained.     

Real rank and squaring mappings for unital -algebras

It is proved that if is a compact Hausdorff space of Lebesgue dimension , then the squaring mapping , defined by , is open if and only if . Hence the Lebesgue dimension of can be detected from openness of the squaring maps . In the case it is proved that the map , from the selfadjoint elements of a unital -algebra into its positive elements, is open if and only if is isomorphic to for some compact Hausdorff space with .

     

Geometric properties of the sections of solutions to the Monge-Ampère equation

In this paper we establish several geometric properties of the cross sections of generalized solutions to the Monge-Ampère equation , when the measure satisfies a doubling property. A main result is a characterization of the doubling measures in terms of a geometric property of the cross sections of . This is used to obtain estimates of the shape and invariance properties of the cross sections that are valid under appropriate normalizations.

     

Fractional diffusion models of option prices in markets with jumps

Most of the recent literature dealing with the modeling of financial assets assumes that the underlying dynamics of equity prices follow a jump process or a Lévy process. This is done to incorporate rare or extreme events not captured by Gaussian models. Of those financial models proposed, the most interesting include the CGMY, KoBoL and FMLS. All of these capture some of the most important characteristics of the dynamics of stock prices. In this article we show that for these particular Lévy processes, the prices of financial derivatives, such as European-style options, satisfy a fractional partial differential equation (FPDE). As an application, we use numerical techniques to price exotic options, in particular barrier options, by solving the corresponding FPDEs derived.     

Classification of “Real” Bloch-bundles: Topological quantum systems of type AI

We provide a classification of type AI topological quantum systems in dimension $d=1,2,3,4$ which is based on the equivariant homotopy properties of “Real” vector bundles. This allows us to produce a fine classification able to take care also of the non stable regime which is usually not accessible via $K$-theoretic techniques. We prove the absence of non-trivial phases for one-band AI free or periodic quantum particle systems in each spatial dimension by inspecting the second equivariant cohomology group which classifies “Real” line bundles. We also show that the classification of “Real” line bundles suffices for the complete classification of AI topological quantum systems in dimension $d⩽3$. In dimension $d=4$ the determination of different topological phases (for free or periodic systems) is fixed by the second “Real” Chern class which provides an even labeling identifiable with the degree of a suitable map. Finally, we provide explicit realizations of non trivial 4-dimensional free models for each given topological degree.     

企业经营者股票期权薪酬机制的模型探讨

采用 Black-Scholes期权定价理论 ,建立了激励机制下企业经营者股票期权薪酬机制的分析、操作模型