Chemometric analysis of targeted 3DLC-DAD data for accurate and precise quantification of phenytoin in wastewater samples

A variety of pharmaceuticals have been found in various water systems, including wastewater treatment effluent. Due to the possible environmental and human health implications, it is important to be able to quickly and reliably quantify the amount of pharmaceuticals and personal care products that may be present in such samples. To this end, a new chromatographic analysis technique involving three dimensions of liquid chromatography, including selective comprehensive separations in the second and third dimensions, was applied to the analysis of a wastewater treatment plant effluent (WWTPE) sample using both standard addition and external calibrations. Iterative key set factor analysis alternating least squares with the application of both sample and spectral selectivity constraints was used to resolve the phenytoin peak at a concentration corresponding to about 40 parts-per-trillion using UV absorbance detection. Both the precision and accuracy of the method are investigated. We determined that the concentration of phenytoin in WWTPE using selective three dimensional liquid chromatography with diode array detection was 42 ± 1 ng/L, after resolution from an unknown interferent. The estimated concentration was not significantly different from that obtained by the reference 2DLC/MS/MS method, but was four and a half times more precise.     

The fundamental groups of a triangular algebra

A finite dimensional algebra A (over an algebraically closed field) is called triangular if its ordinary quiver has no oriented cycles. To each presentation (Q I) of A is attached a fundamental group π₁(Q I), and A is called simply connected if π₁(Q I) is trivial for every presentation of A. In this paper, we provide tools for computations with the fundamental groups, as well as criteria for simple connectedness. We find relations between the fundamental groups of A and the first Hochschild cohomology H ¹ (A A).     

Evolution of curves on a surface driven by the geodesic curvature and external force

We study a flow of closed curves on a given graph surface driven by the geodesic curvature and external force. Using vertical projection of surface curves to the plane we show how the geodesic curvature-driven flow can be reduced to a solution of a fully nonlinear system of parabolic differential equations. We show that the flow of surface curves is gradient-like, i.e. there exists a Lyapunov functional nonincreasing along trajectories. Special attention is placed on the analysis of closed stationary surface curves. We present sufficient conditions for their dynamic stability. Several computational examples of evolution of surface curves driven by the geodesic curvature and external force on various surfaces are presented in this article. We also discuss a link between the geodesic flow and the edge detection problem arising from the image segmentation theory.     

Interpolation Methods for Curve Construction

This paper surveys a wide selection of the interpolation algorithms that are in use in financial markets for construction of curves such as forward curves, basis curves, and most importantly, yield curves. In the case of yield curves the issue of bootstrapping is reviewed and how the interpolation algorithm should be intimately connected to the bootstrap itself is discussed. The criterion for inclusion in this survey is that the method has been implemented by a software vendor (or indeed an inhouse developer) as a viable option for yield curve interpolation. As will be seen, many of these methods suffer from problems: they posit unreasonable expections, or are not even necessarily arbitrage free. Moreover, many methods lead one to derive hedging strategies that are not intuitively reasonable. In the last sections, two new interpolation methods (the monotone convex method and the minimal method) are introduced, which it is believed overcome many of the problems highlighted with the other methods discussed in the earlier sections.     

Riemann-Hilbert problem for first order complex equations of mixed type with degenerate curve

This paper considers the Riemann-Hilbert problem for linear mixed（elliptichyperbolic） complex equations of first order with degenerate curve in a simply connected domain. We first give the representation theorem and uniqueness of solutions for such boundary value problem. Then by using the methods of successive iteration and parameter extension, the existence of solutions for this problem is proved.     

关于非退化的二阶曲线的分类研究

从抛物线的一种判定方法出发,借助于欧氏平面上非退化的二阶曲线的度量性质,通过对欧氏平面上非退化二阶曲线类型的研究,探究出确定非退化二阶曲线类型的若干定理。     

中等收入定位与人口度量模型研究

我国正处于经济转型期和收入分配格局的重要调整期,监控收入分配格局的变化具有重大意义.首先,针对中等收入定位与人口度量模型研究,构建新的洛伦兹模型L(p)=[1-(1-p)~αe~(-βp)][1-(1-p)~γe~(ηp)],与现有的经典洛伦兹模型做比较,拟合精度最优.其次,针对收入空间法和入口空间法的缺陷,给出相应解决对策.最后,提出中等收入人群的新定义,在此基础上构建了中等人口收入效用指数模型.     

Judging or setting weight steady-state of rational Bezier curves and surfaces

Many works have investigated the problem of reparameterizing rational B~zier curves or surfaces via MSbius transformation to adjust their parametric distribution as well as weights, such that the maximal ratio of weights becomes smallerthat some algebraic and computational properties of the curves or surfaces can be improved in a way. However, it is an indication of veracity and optimization of the reparameterization to do prior to judge whether the maximal ratio of weights reaches minimum, and verify the new weights after MSbius transfor- mation. What＇s more the users of computer aided design softwares may require some guidelines for designing rational B6zier curves or surfaces with the smallest ratio of weights. In this paper we present the necessary and sufficient conditions that the maximal ratio of weights of the curves or surfaces reaches minimum and also describe it by using weights succinctly and straightway. The weights being satisfied these conditions are called being in the stable state. Applying such conditions, any giving rational B6zier curve or surface can automatically be adjusted to come into the stable state by CAD system, that is, the curve or surface possesses its optimal para- metric distribution. Finally, we give some numerical examples for demonstrating our results in important applications of judging the stable state of weights of the curves or surfaces and designing rational B6zier surfaces with compact derivative bounds.     

On the size of the Shafarevich--Tate group of elliptic curves over function fields

Let E be a nonconstant elliptic curve, over a global field K of positive, odd characterisitc. Assuming the finiteness of the Shafarevich-Tate group of E, we show that the order of theShafarevich-Tate group of E, is given by O ^{(N1/2+6 log(2)/ log(q))}, where N is the conductor of E,q isthe cardinality of the finite field of constants of K, and where the constant in the bound depends only on K. The method of proof is to workwith the geometric analog of the Birch-Swinnerton Dyer conjecture for thecorresponding elliptic surface over the finite field, as formulatedby Artin-Tate, and to examine the geometry of this elliptic surface.