砂砾岩油藏渗透系数研究

为了掌握砂砾岩油藏渗流规律,基于砂砾岩中砾和砂含量及其排列方式不同,开展了理论和实验研究。把砂砾岩孔隙度和渗透率设为砾、砂含量的函数,再基于Kozeny-Carman方程建立渗透率与孔隙度和颗粒粒径的函数关系。研究表明,砂砾岩组成及颗粒排列方式是控制砂砾岩渗透系数的主要因素,砂砾岩渗透率与孔隙度为一种线性关系。水驱油实验进一步表明,束缚水饱和度依赖于砂、砾含量,含水上升快,揭示了砂砾岩油藏特有的渗流特点。     

Global optimization for first order Markov Random Fields with submodular priors

This paper copes with the global optimization of Markovian energies. Energies are defined on an arbitrary graph and pairwise interactions are considered. The label set is assumed to be linearly ordered and of finite cardinality, while each interaction term (prior) shall be a submodular function. We propose an algorithm that computes a global optimizer under these assumptions. The approach consists of mapping the original problem into a combinatorial one that is shown to be globally solvable using a maximum-flow/s-t minimum-cut algorithm. This restatement relies on considering the level sets of the labels (seen as binary variables) instead of the label values themselves. The submodularity assumption of the priors is shown to be a necessary and sufficient condition for the applicability of the proposed approach. Finally, some numerical results are presented.     

Solving Matrix Games with I-fuzzy Payoffs: Pareto-optimal Security Strategies Approach

A recent research work of Clemente et al. [12] on Pareto-optimal security strategies (POSS) in matrix games with fuzzy payoffs is extended to I-fuzzy scenario. Besides, the membership and the non-membership functions of the I-fuzzy values for both players are obtained by employing the technique of multiobjective optimization. The presented approach provides an efficient solution to a class of I-fuzzy matrix games with piecewise linear membership and non-membership functions. This class also includes I-fuzzy matrix games with triangular and trapezoidal I-fuzzy numbers as special cases. Further, POSS approach also provides an approximate solution to I-fuzzy matrix games with payoffs as general I-fuzzy numbers.     

The tricriterion shortest path problem with at least two bottleneck objective functions

The focus of this paper is on the tricriterion shortest path problem where two objective functions are of the bottleneck type, for example MinMax or MaxMin. The third objective function may be of the same kind or we may consider, for example, MinSum or MaxProd. Let p(n) be the complexity of a classical single objective algorithm responsible for this third function, where n is the number of nodes and m be the number of arcs of the graph. An O(m²p(n)) algorithm is presented that can generate the minimal complete set of Pareto-optimal solutions. Finding the maximal complete set is also possible. Optimality proofs are given and extensions for several special cases are presented. Computational experience for a set of randomly generated problems is reported.     

On a Problem of Judicious k‐Partitions of Graphs

For positive integers and m , let be the smallest integer such that for each graph G with m edges there exists a k‐partition in which each contains at most edges. Bollobás and Scott showed that . Ma and Yu posed the following problem: is it true that the limsup of tends to infinity as m tends to infinity? They showed it holds when k is even, establishing a conjecture of Bollobás and Scott. In this article, we solve the problem completely. We also present a result by showing that every graph with a large k‐cut has a k‐partition in which each vertex class contains relatively few edges, which partly improves a result given by Bollobás and Scott.     

Production of monoclonal antibodies against hop-derived (Humulus lupulus L.) prenylflavonoids and the development of immunoassays

Monoclonal antibodies against the hop-derived prenylated chalcone xanthohumol (X) and the prenylated flavonoids isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) were developed. Carboxylic acid haptens of X, IX and 8-PN were synthesized by linking a spacer to their C4′-OH group followed by subsequent coupling to bovine serum albumin (BSA) to form conjugates that were employed as immunogens in BALB/c mice to raise antibodies. The monoclonal antibodies that were secreted from the established hybridoma cell lines proved, in cross-reactivity studies, to possess highly specific binding capacities in an optimized competitive indirect ELISA. The immunoassays make use of immunogen-coated microtiterplates and a peroxidase-labeled anti-mouse IgG₁ secondary antibody with ABTS as a chromogenic substrate. For X the IC₅₀ value derived from the standard curve was 62.91 ng mL⁻¹, and for both IX and 8-PN 37.15 ng mL⁻¹. The assay was validated for the quantitative analysis of X, IX and 8-PN in urine and serum. A simple sample pretreatment procedure using a diethyl ether extraction was optimized and the recoveries and matrix effects were assessed. The validity of the established assay was tested and mean inter- and intra-assay variations in urine were 2.32% and 1.91%, respectively for X, 6.24% and 2.39%, respectively for IX and 7.18% and 0.74%, respectively for 8-PN. In serum, the mean inter- and intra-assay variations were 8.90% and 1.37%, respectively for X, 6.13% and 1.57%, respectively for IX and 6.13% and 2.43%, respectively for 8-PN. Furthermore, the method demonstrated excellent accuracy and significant correlation with measurements by an established and validated HPLC-MS method.     

Improving the visualization of the Pareto-optimal front for the multi-response optimization of chromatographic determinations

The paper shows tools to visualize and more easily interpret the effect that some experimental factors may exert on analytical responses of interest when optimization of several responses is needed.It is based on an adaptation of the parallel coordinate plot, a tool for graphical representation of points in multidimensional spaces that, theoretically and contrary to the usual Cartesian plots, does not have limits in the dimension of the points being depicted.The joint use of the Pareto-optimal solutions and their visualization allows a deeper knowledge about the problem at hand as well as the wise selection of the conditions of experimental factors for achieving specific goals about the responses.Although the methodology is for a general use, the procedure, its interpretation and usefulness is shown with several analytical cases in chromatography. The first one refers to the experimental conditions to obtain simultaneously the maximum allowable area for both the peak of the malachite green and its metabolite leucomalachite green in fish by liquid chromatography with tandem mass spectrometry detection (LC–MS/MS). The second one is about the simultaneous determination of steroid hormones estrone and 17-α-ethinylestradiol by gas chromatography–mass spectrometry (GC/MS). In the last case, the chromatographic separation by GC/MS of the diastereoisomers, α- and β-estradiol is needed taking into account that these hormones have the same mass fragments.     

Gas-hydrate formation, agglomeration and inhibition in oil-based drilling fluids for deep-water drilling

One of the main challenges in deep-water drilling is gas-hydrate plugs, which make the drilling unsafe. Some oil-based drilling fluids (OBDF) that would be used for deep-water drilling in the South China Sea were tested to investigate the characteristics of gas-hydrate formation, agglomeration and inhibition by an experimental system under the temperature of 4 ℃ and pressure of 20 MPa, which would be similar to the case of 2000 m water depth. The results validate the hydrate shell formation model and show that the water cut can greatly influence hydrate formation and agglomeration behaviors in the OBDF. The oleophobic effect enhanced by hydrate shell formation which weakens or destroys the interfacial films effect and the hydrophilic effect are the dominant agglomeration mechanism of hydrate particles. The formation of gas hydrates in OBDF is easier and quicker than in water-based drilling fluids in deep-water conditions of low temperature and high pressure because the former is a W/O dispersive emulsion which means much more gas-water interfaces and nucleation sites than the later. Higher ethylene glycol concentrations can inhibit the formation of gas hydrates and to some extent also act as an anti-agglomerant to inhibit hydrates agglomeration in the OBDF.