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21.
J. Fekete M. Milen L. Hazai L. Poppe Cs. Szántay A. Kettrup I. Gebefügi 《Chromatographia》2003,57(3-4):147-153
Summary Reversed (RP-HPLC) and normal phase chromatographic (NP-HPLC) separations have been developed for diastereomers ofN-acyl-1-methyl-1,2,3,4-tetrahydo-β-carbolines which are acylated derivatives of simple natural β-carboline alkaloids. Separations
of derivatives having different acyl moieties in theO,O-diacyl-tartaric acid ester subtituent differed remarkably. Little or no resolution in either NP-HPLC or RP-HPLC could be
achieved with the diacetyl-tartrate derivative. Base-line separation by RP-HPLC but no separation by NP-HPLC was possible
with the bulkier and more apolar dipivaloyl derivative. Retention order of the bis-benzoylated diastereomers was reversed
and separation time increased dramatically by RP-HPLC. Good separation of the medium polarity, but rigid,N-camphanyl derivative by NP-HPLC has been achieved, whereas RP-HPLC could not be used for separation of these diastereomers.
Separability of different diastereomers was highly dependent on polarity and rigidity of the derivatizingN-acyl moieties. Conformational analysis by molecular mechanics and comparison of the lowest energy conformational states of
the diastereomers was applied to rationalise separation-retention behaviour of stereoisomers by RP-HPLC.
Presented at Balaton Symposium '01 on High-Performance Separation Methods, Siófok, Hungary, September 2–4, 2001 相似文献
22.
Adaptation of Cu/ZnO/Al_2O_3 to Temperature Change in Methanol Synthesis from CO_2 Hydrogenation 下载免费PDF全文
Jialin Tao Ki-Won Jun Kyu-Wan Lee. Chemical Technology Lab. Korea Research Institute of Chemical Technology P.O. Box Yusong Taejon - Korea. Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu ChinaManus 《天然气化学杂志》2002,(Z1)
The induction behavior in CO2 hydrogenation was studied by varying the reaction temperature to investigate the adaptation of the Cu/ZnO/Al2O3 catalyst to the temperature change. The results indicated that a used catalyst had a tendency to keep the last running state in new reaction conditions for MeOH formation, and that this tendency was related to the difference in Cu/Cun+ ratio caused by CO2 and CO produced at different reaction temperatures. However, the reverse water-gas shift reaction (RWGS) induced at four temperatures was completely different from that of methanol synthesis. It implied that the two so-called competitive reactions in CO2+H2, RWGS and methanol synthesis, have different active centers. 相似文献
23.
We herein report on solution structural studies of Ru^Ⅱ catalysts (3a, 9) composed of achiral bisphosphine ligands (4, 8) and the enantiopure 1,2-diphenylethylenediamine (DPEN). Complete chiral induction from enantiopure (R,R)-DPEN to achiral bisphosphine ligand 3a was observed in solution, with the complex adopting a single, stable and non-fluxional (even at 70 ℃) configuration. The coordination of the C=O moiety in 4 to the cationic Run center is considered to be of key importance in providing the higher thermodynamic and kinetic rotation barrier for the flexible bisphosphine ligand in the complex. The obtained enantioselectivity (91% enantiomeric excess) and sense of chiral induction in the hydrogenation of acetophenone were found to be solely dependent on the chirality of the 1,2-diamine. Consistent with the hydrogenation product, the (R,R)-DPEN induces a M-conformation (fight-handed) chirality for flexible phosphine ligand 4 in the complex, resulting in a 2,2-configuration about the Ru^Ⅱ center. 相似文献
24.
Shimpei Sugiyama 《Tetrahedron letters》2005,46(39):6771-6775
Treatment of optically active 1-chlorovinyl p-tolyl sulfoxides, which were synthesized from symmetrical ketones and (R)-(−)-chloromethyl p-tolyl sulfoxide in three steps, with lithium enolate of carboxylic acid tert-butyl esters gave optically active adducts having a substituent at the α-position with high 1,4-chiral induction from the sulfur chiral center in high yields. The adducts were converted to optically active esters and carboxylic acids having a chiral center at the α-position. When this addition reaction was carried out with the ester enolate generated from excess carboxylic acid tert-butyl ester with LDA in the presence of HMPA, the diastereomer of the adduct was obtained. By using the two reaction conditions for the generation of the ester enolates, a new method for asymmetric synthesis of both enantiomers of carboxylic acid derivatives having a substituent at the α-position from the one chiral source, (R)-(−)-chloromethyl p-tolyl sulfoxide, was realized. 相似文献
25.
Laser Doppler anemometry is used for the measurements of the plasma and particle velocity profiles in the coil region of an inductively coupled r.f. plasma. Results are reported for a 50 mm i.d. induction plasma torch operated at atmospheric pressure with argon as the plasma gas. The oscillator frequency is 3 MHz and the plate power is varied between 4.6 and 10.5 kW. Plasma velocity measurements are obtained using a fine carbon powder as a tracer. Measurements are also given for larger silicon particles (
) centrally injected into the discharge under different operating conditions.Nomenclature
d
p
particle diameter
-
P
0
plasma power
-
Q
1
powder carrier gas flow rate
-
Q
2
plasma gas flow rate
-
Q
3
sheath gas flow rate
-
r
distance in the radial direction
-
V
axial plasma velocity
-
V
p
axial particle velocity
-
Z
distance in the axial direction
-
standard deviation 相似文献
26.
Hidetaka KogaEiji Wada 《Tetrahedron letters》2003,44(4):715-719
An efficient catalytic double asymmetric induction during the tandem transetherification-intramolecular hetero Diels-Alder reaction has been developed. The enantioselective tandem reaction of methyl (E)-4-methoxy-2-oxo-3-butenoate with rac-6-methyl-5-hepten-2-ol has been achieved to provide methyl (2R,4aS,8aR)-3,4,4a,8a-tetrahydro-2,5,5-trimethyl-2H,5H-pyrano[4,3-b]-pyran-7-carboxylate in good yield with effective kinetic resolution (up to 95% selectivity), high diastereoselectivity (up to 92% de), and high enantioselectivity (up to 97% ee) in the presence of (S,S)-tert-Bu-bis(oxazoline)-Cu(SbF6)2 and 5 Å molecular sieves. 相似文献
27.
Andrea Guerrini Greta Varchi Rizzo Daniele Cristian Samorì Arturo Battaglia 《Tetrahedron》2007,63(33):7949-7969
Reactions of chiral (2S)-enolates of dioxolan-4-ones, derived from lactic, mandelic, and phenyllactic acids, with aliphatic (SS)- and (SR)-tert-butylsulfinyl aldimines afforded conformationally restrained C2-disubstituted N,O-orthogonally protected 3-amino-2-hydroxyalkanoates in the form of N-sulfinyl protected 1′-aminodioxolan-4-ones. The product distribution showed that there is significant kinetic selectivity, due to the presence of ‘matched’ and ‘mismatched’ components, between the (S)- or (R)-tert-butylsulfinyl aldimines and the (2S)-enolates of the 1,3-dioxolan-4-ones. Selective methoxide-induced removal of the acetal group of the N-sulfinyl-1′-aminodioxolanones yielded the corresponding N-sulfinyl protected methyl alkanoates. In addition, the selective acid-induced removal of the sulfinyl group of the N-sulfinyl-1′-aminodioxolanones provided the corresponding N-unprotected 1′-aminodioxolanones, whose base-induced cyclization afforded the corresponding β-lactams. 相似文献
28.
Hadeer Darwish Sarah Alharthi Radwa A. Mehanna Samar S. Ibrahim Mustafa A. Fawzy Saqer S. Alotaibi Sarah M. Albogami Bander Albogami Sedky H. A. Hassan Ahmed Noureldeen 《Molecules (Basel, Switzerland)》2022,27(19)
Chemotherapy is an aggressive form of chemical drug therapy aiming to destroy cancer cells. Adjuvant therapy may reduce hazards of chemotherapy and help in destroying these cells when obtained from natural products, such as medical plants. In this study, the potential therapeutic effect of Rosa damascena callus crude extract produced in vitamin-enhanced media is investigated on colorectal cancer cell line Caco-2. Two elicitors, i.e., L-ascorbic acid and citric acid at a concentration of 0.5 g/L were added to the callus induction medium. Callus extraction and the GC–MS analysis of methanolic crude extracts were also determined. Cytotoxicity, clonogenicity, proliferation and migration of Caco-2 colorectal cancer cells were investigated using MTT cytotoxicity, colony-forming, Ki-67 flow cytometry proliferation and Migration Scratch assays, respectively. Our results indicated that L-ascorbic acid treatment enhanced callus growth parameters and improved secondary metabolite contents. It showed the least IC50 value of 137 ug/mL compared to 237 ug/mL and 180 ug/mL in the citric acid-treated and control group. We can conclude that R. damascena callus elicited by L-ascorbic acid improved growth and secondary metabolite contents as well as having an efficient antiproliferative, anti-clonogenic and anti-migratory effect on Caco-2 cancer cells, thus, can be used as an adjuvant anti-cancer therapy. 相似文献
29.
发射速度和能量转换效率是同步感应线圈型电磁发射装置(SICEML)最重要的两项指标。驱动线圈和电枢的结构参数、驱动线圈匝数以及电枢初始触发位置都会对这两项指标产生影响。以上述参数为变量,以发射速度和能量转换效率之积为目标函数,引入遗传算法对单级SICEML参数进行了优化设计,并利用有限元软件进行了仿真验证。结果表明:在储能与发射装置总体体积不变的前提下,优化后的系统效率由5.38%提高到13.6%,出口速度由38 m/s提高到61 m/s,系统性能得到明显改善。利用单级SICEML样机进行了堵驻试验,结果与仿真结果吻合较好,验证了本文提出的遗传算法的可行性。 相似文献
30.
基于阵列永磁体的特点以及光隔离器对磁场的需求设计了两种适用于高功率隔离器的永磁系统,分析了其磁场分布、磁场非均匀性对隔离度的影响,研究了磁体装配误差对磁场的影响。研究结果表明:通过引入斜向磁化永磁体,选择合适的磁化角度和磁体长度,可以提高永磁体的磁场强度,大幅度减小旋转器所需磁光晶体长度;受磁场非均匀性影响的隔离度与磁光晶体的孔径、长度以及入射激光的光斑半径有关,当晶体长度一定时,减小晶体半径和入射光的半径可以显著提高隔离度。在入射光半径为1.5 mm、磁光晶体半径5 mm时,对应的隔离度分别为105.8 dB和45.4 dB。 相似文献