单离子束技术概述

 对单离子束的发展和应用作了介绍。结合我国首台单离子束装置CAS-LIBB,综合讨论了准直器限流型和静电透镜聚焦型两种典型单离子束的技术结构。限流型结构简单但定位精度有限,聚焦型条件苛刻但可获得亚微米束,是单离子束发展的趋势。评估了前探测、全前置探测和后探测3种单离子束探测方式及其特点,研究了这3种探测方式对辐照离子的计数精度和单离子束品质产生的影响。对CAS-LIBB装置研制了光导型全前置探测器以提高计数精度和束流品质。最后设计了快速荧光在线检测技术方案。     

有机化学在线课堂教学实践探索

The spring semester of 2020 is affected by the new coronary pneumonia epidemic, which prevents the normal classroom teaching of universities in China. Nankai University actively responds to the request of "Suspended classes but not stop teaching and learning" proposed by the Ministry of Education. The online teaching software such as "Rain Classroom" and "Tencent Meeting" are used to provide online teaching to undergraduate students. This article takes organic chemistry teaching as an example and introduces the implementation process and effectiveness of online teaching. According to the particularity of online teaching, teachers must change the teaching mode to ensure the teaching work carried out effectively.     

Online scheduling of parallel jobs on two machines is 2-competitive

We consider online scheduling of parallel jobs on parallel machines. For the problem with two machines and the objective of minimizing the makespan, we show that 2 is a tight lower bound on the competitive ratio. For the problem with m machines, we derive lower bounds using an ILP formulation.     

Linear programming with online learning

We propose online decision strategies for time-dependent sequences of linear programs which use no distributional and minimal geometric assumptions about the data. These strategies are obtained through Vovk's aggregating algorithm which combines recommendations from a given strategy pool. We establish an average-performance bound for the resulting solution sequence.     

以学生为中心的有机化学在线教学及成绩评定

Under the "constructing Chinese Golden Lessons" and "ensuring learning undisrupted when classes are disrupted" appealed by Ministry of Education, we implemented organic chemistry online teaching schemes including self-study courses online, resolving doubts and expanding webcast explanation, classification-summarization and doing exercises online, as well as online discussion-answering. Students' performance was scored based process assessment including 10% self-study online, 10% resolving doubts and expanding webcast, 10% classification-summarization and doing exercises online, 5% online discussion-answering, 15% mid-term examination, and 50% semester final examination. The goal of student-centered teaching was achieved and teaching quality during epidemic period was ensured.     

Enhancement of the conductivity detection signal in capillary electrophoresis systems using neutral cyclodextrins as sweeping agents

Conductivity detection is a universal detection technique often encountered in electrophoretic separation systems, especially in modern chip‐electrophoresis based devices. On the other hand, it is sparsely combined with another contemporary trend of enhancing limits of detection by means of various preconcentration strategies. This can be attributed to the fact that a preconcentration experimental setup usually brings about disturbances in a conductivity baseline. Sweeping with a neutral sweeping agent seems a good candidate for overcoming this problem. A neutral sweeping agent does not hinder the conductivity detection while a charged analyte may preconcentrate on its boundary due to a decrease in its effective mobility. This study investigates such sweeping systems theoretically, by means of computer simulations, and experimentally. A formula is provided for the reliable estimation of the preconcentration factor. Additionally, it is demonstrated that the conductivity signal can significantly benefit from slowing down the analyte and thus the overall signal enhancement can easily overweight amplification caused solely by the sweeping process. The overall enhancement factor can be deduced a priori from the linearized theory of electrophoresis implemented in the PeakMaster freeware. Sweeping by neutral cyclodextrin is demonstrated on an amplification of a conductivity signal of flurbiprofen in a real drug sample. Finally, a possible formation of unexpected system peaks in systems with a neutral sweeping agent is revealed by the computer simulation and confirmed experimentally.     

Real-time Event Recognition and Analysis System for Nanopore Study

To achieve fast and accurate analysis of weak current signal of nanopore-based single molecule detection, an online data process based on adaptive threshold algorithm with data buffering technique and finite impulse response filtering was designed. A software system based on the data process was developed for online recognition and analysis of nanopore events during nanopore experiment. To testify the performance of the algorithm and software system, ideal signals with different noise level (20–100 pA) were generated at bandwidth ranging from 3 kHz to 100 kHz. The result showed that this software system was stable at different bandwidths and sampling rates and could be used in analyzing the signals at high noise. The proposed software system was further applied to aerolysin nanopore experiment for detection of poly(dA)₄ molecules. The results showed that the data process system could be applied in real nanopore recording experiment with high accuracy and speed.     

Online ATR-IR investigations and mechanistic understanding of the carbonylation of epoxides - the selective synthesis of lactones or polyesters from epoxides and CO

In situ ATR-IR spectroscopy is applied as a powerful tool to study the factors that control the reaction of epoxides with carbon monoxide in the presence of [Lewis acid]⁺[Co(CO)₄]⁻ salts. Based on these investigations, a consistent mechanistic scheme is presented, comprising the main lactone and polyester products and minor components, e.g., acetone and crotonic acid derivatives. β-Alkoxy-acyl-cobalttetracarbonyl species are shown to be key intermediates from which two reaction routes start in dependence of the applied Lewis acid (LA). Labile LA-alkoxy combinations favor a backbiting process of the oxygen function on the Co-acyl bond, primarily producing lactone products. More stable LA-alkoxy entities are unreactive toward PO conversion and afford a polymerization reaction after the addition of a nucleophile. In that case, the Lewis acid remains bonded to the chain end.     

物理化学课程在线教学实践与效果分析

The main measures and experiences of online physical chemistry teaching through Ding Talk platform in Bohai University was introduced. Through the practice of the whole semester, it can be seen that the modular teaching mode of "simplicity-detail-induction" constructed by physical chemistry teaching team is conducive to match students with different self-learning abilities with different levels of teaching. The question-and-answer video induction class can fully arouse students' learning enthusiasm, which is favorable for the perfect realization of teaching and teacher-student interaction. With the double guarantee of meticulous and transparent teaching management and the accompanying process assessment, the overall goal achievement degree of the whole semester reached beyond 80%, and the sub-goal achievement degree reached over 60%, which provided reference for relevant teaching.     

疫情防控期间线上教学的初步探索

This paper introduces our initial attempt and practice to carry out online teaching during the period of prevention and control of the new type coronavirus (COVID-19). Online teaching in our college generally adopts three means:MOOC network platform, QQ group and Tencent classroom live broadcast platform. This paper introduces in detail the online teaching, guiding students to participate in discussions, and the effective control of online teaching and effective combination of expertise and epidemic knowledge. The achievements were satisfied.