全文获取类型
收费全文 | 48213篇 |
免费 | 6144篇 |
国内免费 | 4670篇 |
专业分类
化学 | 13223篇 |
晶体学 | 1021篇 |
力学 | 10215篇 |
综合类 | 749篇 |
数学 | 17114篇 |
物理学 | 16705篇 |
出版年
2024年 | 124篇 |
2023年 | 540篇 |
2022年 | 1020篇 |
2021年 | 1115篇 |
2020年 | 1357篇 |
2019年 | 1221篇 |
2018年 | 1246篇 |
2017年 | 1712篇 |
2016年 | 1923篇 |
2015年 | 1498篇 |
2014年 | 2531篇 |
2013年 | 3516篇 |
2012年 | 2920篇 |
2011年 | 3297篇 |
2010年 | 2794篇 |
2009年 | 3112篇 |
2008年 | 3050篇 |
2007年 | 3062篇 |
2006年 | 2793篇 |
2005年 | 2574篇 |
2004年 | 2210篇 |
2003年 | 2030篇 |
2002年 | 1778篇 |
2001年 | 1501篇 |
2000年 | 1422篇 |
1999年 | 1270篇 |
1998年 | 1162篇 |
1997年 | 1006篇 |
1996年 | 843篇 |
1995年 | 690篇 |
1994年 | 621篇 |
1993年 | 498篇 |
1992年 | 500篇 |
1991年 | 383篇 |
1990年 | 313篇 |
1989年 | 231篇 |
1988年 | 205篇 |
1987年 | 149篇 |
1986年 | 108篇 |
1985年 | 135篇 |
1984年 | 127篇 |
1983年 | 62篇 |
1982年 | 94篇 |
1981年 | 61篇 |
1980年 | 29篇 |
1979年 | 55篇 |
1978年 | 39篇 |
1977年 | 39篇 |
1976年 | 14篇 |
1957年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
11.
Erosion and sediments transport processes have a great impact on industrial structures and on water quality. Despite its limitations, the Saint‐Venant‐Exner system is still (and for sure for some years) widely used in industrial codes to model the bedload sediment transport. In practice, its numerical resolution is mostly handled by a splitting technique that allows a weak coupling between hydraulic and morphodynamic distinct softwares but may suffer from important stability issues. In recent works, many authors proposed alternative methods based on a strong coupling that cure this problem but are not so trivial to implement in an industrial context. In this work, we then pursue 2 objectives. First, we propose a very simple scheme based on an approximate Riemann solver, respecting the strong coupling framework, and we demonstrate its stability and accuracy through a number of numerical test cases. However, second, we reinterpret our scheme as a splitting technique and we extend the purpose to propose what should be the minimal coupling that ensures the stability of the global numerical process in industrial codes, at least, when dealing with collocated finite volume method. The resulting splitting method is, up to our knowledge, the only one for which stability properties are fully demonstrated. 相似文献
12.
Molecularly imprinted polymer (MIP) computational design is expected to become a routine technique prior to synthesis to produce polymers with high affinity and selectivity towards target molecules. Furthermore, using these simulations reduces the cost of optimizing polymerization composition. There are several computational methods used in MIP fabrication and each requires a comprehensive study in order to select a process with results that are most similar to properties exhibited by polymers synthesized through laboratory experiments. Until now, no review has linked computational strategies with experimental results, which are needed to determine the method that is most appropriate for use in designing MIP with high molecular recognition. This review will present an update of the computational approaches started from 2016 until now on quantum mechanics, molecular mechanics and molecular dynamics that have been widely used. It will also discuss the linear correlation between computational results and the polymer performance tests through laboratory experiments to examine to what extent these methods can be relied upon to obtain polymers with high molecular recognition. Based on the literature search, density functional theory (DFT) with various hybrid functions and basis sets is most often used as a theoretical method to provide a shorter MIP manufacturing process as well as good analytical performance as recognition material. 相似文献
13.
14.
This work is concerned with the extension of the Jacobi spectral Galerkin method to a class of nonlinear fractional pantograph differential equations. First, the fractional differential equation is converted to a nonlinear Volterra integral equation with weakly singular kernel. Second, we analyze the existence and uniqueness of solutions for the obtained integral equation. Then, the Galerkin method is used for solving the equivalent integral equation. The error estimates for the proposed method are also investigated. Finally, illustrative examples are presented to confirm our theoretical analysis. 相似文献
15.
蛋白质-多糖复合体系作为生物活性物质传递系统的壁材,有着人工合成聚合物或无机物等其他材料不可比拟的多重优势。本文就蛋白质和多糖之间的连接方式及蛋白质-多糖复合体系形成传递系统的多种形式进行了综述,以及对此领域的发展趋势进行了展望。结合蛋白质和多糖的结构特点,二者之间的链接方式分为非共价结合的物理共聚,和共价结合的美拉德偶联、化学交联、酶催化交联等方式,文中分别对各种连接方式的原理和机理,以及其影响因素做了深入阐述。以蛋白质-多糖复合体系为壁材对活性物质的传递形式大体上分成乳化系统、胶束、纳米凝胶、分子复合物以及壳核结构等系统。不同的活性物质的特征和传递需求,可针对性地选择合适结构的蛋白质和多糖种类以及二者的连接方式和传递系统的形式。并且,随着研究的逐步发展和推进,此领域的发展趋势朝着智能化和靶向性的方向进行。目前活性物质的蛋白质-多糖复合体系的传递系统,还依然面临着系统设计、评价和应用等多方面的挑战,这就要求我们在更全面更深入了解认识其对活性物质影响和功效的基础上,安全合理地设计和深入细致地评价活性成分的传递系统。 相似文献
16.
17.
18.
Harsha K. Tripathy Nair S.V. Manju Sreekanth Dittakavi Ram Murthi Bestha Ramesh Mullangi 《Biomedical chromatography : BMC》2020,34(12):e4953
Larotrectinib is a first-generation tropomyosin kinase inhibitor, approved for the treatment of solid tumors. In this paper, we present a validated dried blood spot (DBS) method for the quantitation of larotrectinib from mouse blood using HPLC–MS/MS, which was operated under multiple reaction monitoring mode. To the DBS disc cards, acidified methanol enriched with internal standard (IS; enasidenib) was added and extracted using tert-butyl methyl ether as an extraction solvent with sonication. Chromatographic separation of larotrectinib and the IS was achieved on an Atlantis dC18 column using 10 mm ammonium formate–acetonitrile (30:70, v/v) delivered at a flow-rate of 0.80 ml/min. Under these optimized conditions, the retention times of larotrectinib and the IS were ~0.93 and 1.37 min, respectively. The total run time was 2.50 min. Larotrectinib and the IS were analyzed using positive ion scan mode and parent–daughter mass to charge ion (m/z) transitions of 429.1 → 342.1 and 474.1 → 267.1, respectively, were used for the quantitation. The calibration range was 1.06–5,080 ng/ml. No matrix effect or carryover was observed. Hematocrit did not influence DBS larotrectinib concentrations. All of the validation parameters met the acceptance criteria. The applicability of the validated method was shown in a mouse pharmacokinetic study. 相似文献
19.
20.
Rong Yin Jihui Zhang Xudong Shang 《Mathematical Methods in the Applied Sciences》2020,43(15):8736-8752
This paper is dedicated to studying the following Schrödinger–Poisson system Under some different assumptions on functions V(x), K(x), a(x) and f(u), by using the variational approach, we establish the existence of positive ground state solutions. 相似文献