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991.
J. Pablo Lamas Lucia Sanchez-PradoMarta Lores Carmen Garcia-JaresMaria Llompart 《Journal of chromatography. A》2010,1217(33):5307-5316
Exposure to fragrance substances is exponentially increasing in our daily life due to the enhanced use of scented products. Some fragrances are known to be important sensitizers, inhalation being an important exposure pathway in indoor environments. A simple and sensitive method based on solid-phase enrichment and solid-phase microextraction (SPME) followed by gas chromatography–mass spectrometry (GC–MS) has been developed for the analysis of 24 volatile fragrance allergens in indoor air. Suspected allergens present in the air (0.2 m3) were adsorbed onto a very small quantity of florisil (25 mg) and then transferred to a SPME fiber in the headspace mode (HS). To the best of our knowledge, this paper describes the first application of SPME for the determination of these compounds in air samples. The experimental parameters affecting the microextraction process have been optimized using a multifactor experimental design strategy. Accuracy, linearity, precision and detection limits (LODs) were evaluated to assess the performance of the proposed method. External calibration, using spiked sorbent standards, and not requiring the complete sampling process (only the SPME step), demonstrated to be suitable for the quantification of all suspected allergens. Recovery studies were performed at three concentration levels (0.04, 1.00 and 50 μg m−3), obtaining quantitative recoveries (≥85%) in most cases. LOD values at the low ng m−3 level were achieved for all the target compounds. The application of the method to daily home air samples demonstrated the ubiquity of this kind of fragrance ingredients in quotidian indoor environments, finding 18 of the 24 considered compounds in concentrations ranging from 0.01 to 56 μg m−3. Benzyl alcohol, linalool, citronellol, ionone and lilial were found in most analyzed samples. 相似文献
992.
Mahbobeh Hosseinyazdi 《Journal of Global Optimization》2008,41(2):283-298
In this paper we give a necessary and sufficient condition for existence of minimal solution(s) of the linear system A * X ≥ b where A, b are fixed matrices and X is an unknown matrix over a lattice. Next, an algorithm which finds these minimal solutions over a distributive lattice is
given. Finally, we find an optimal solution for the optimization problem min {Z = C * X | A * X ≥ b} where C is the given matrix of coefficients of objective function Z.
This research was completed while the author was a visitor of the Center for Informatics and Applied Optimization, University
of Ballarat, Ballarat, Australia. 相似文献
993.
组蛋白去乙酰化酶(HDACs)是近年来治疗肿瘤的重要靶标之一.由于HDACs包含多种亚型,且各亚型的生理功能存在一定的差异,其选择性抑制剂的开发已成为当前的研发热点.我们通过同源模建的HDAC1结构,与已有的HDAC8晶体结构的活性位点进行比较分析,探讨了对两者选择性有重要影响的残基,为基于受体的选择性抑制剂研究提供重要信息.同时选择了52个HDAC抑制剂,分别建立了HDAC1、HDAC8的活性值与对接打分值的线性回归模型.所建的HDAC1和HDAC8的线性构效关系模型的非交叉验证系数R2分别为0.82和0.80,表明具有一定的统计学意义.利用所建模型对已设计合成的化合物进行了预测,预测结果对HDAC1、HDAC8选择性抑制剂的优化改造提供了一定的指导意义. 相似文献
994.
Fredrik Kuivinen 《Discrete Optimization》2011,8(3):459-477
Let (L;?,?) be a finite lattice and let n be a positive integer. A function f:Ln→R is said to be submodular if for all . In this article we study submodular functions when L is a diamond. Given oracle access to f we are interested in finding such that as efficiently as possible. We establish
•
a min–max theorem, which states that the minimum of the submodular function is equal to the maximum of a certain function defined over a certain polyhedron; and •
a good characterisation of the minimisation problem, i.e., we show that given an oracle for computing a submodular f:Ln→Z and an integer m such that , there is a proof of this fact which can be verified in time polynomial in n and ; and •
a pseudopolynomial-time algorithm for the minimisation problem, i.e., given an oracle for computing a submodular f:Ln→Z one can find in time bounded by a polynomial in n and .
995.
996.
This work focuses on an improved exact algorithm for addressing an NP-hard network pricing problem. The method involves an efficient and partial generation of candidate solutions, a recursive scheme for generating improved upper bounds, and a column generation procedure for solving the network-structured subproblems. Its efficiency is assessed against both randomly generated instances involving three distinct topologies as well as instances based on real life situations in telecommunication and freight transportation. 相似文献
997.
Quantum annealing extends simulated annealing by introducing artificial quantum fluctuations. The path-integral Monte Carlo version chosen is population-based and designed to be implemented on a classical computer. Its first application to the graph coloring problem is presented in this paper. It is shown by experiments that quantum annealing can outperform classical thermal simulated annealing for this particular problem. Moreover, quantum annealing proved competitive when compared with the best algorithms on most of the difficult instances from the DIMACS benchmarks. The quantum annealing algorithm has even found that the well-known benchmark graph dsjc1000.9 has a chromatic number of at most 222. This is an improvement on its best upper-bound from a large body of literature. 相似文献
998.
考虑目标函数是线性函数约束条件为线性矩阵不等式的LMI优化问题,讨论了LMI优化问题中的四个择一性定理.每种类型的择一性定理包含两个线性不等式和(或)等式系统,一个原始系统和一个对偶系统.弱择一性定理说明两系统中至多只有其一有解;基于凸集分离理论得到的强择一性定理说明两系统有且仅有其一有解.并在此基础上推导了LMI优化... 相似文献
999.
Amir Averbuch Valery Zheludev Pekka Neittaanmäki Pekka Wartiainen Kari Huoman Kim Janson 《Applied Acoustics》2011,(1):22-34
We present a robust algorithm to detect the arrival of a boat of a certain type when other background noises are present. It is done via the analysis of its acoustic signature against an existing database of recorded and processed acoustic signals. We characterize the signals by the distribution of their energies among blocks of wavelet packet coefficients. To derive the acoustic signature of the boat of interest, we use the Best Discriminant Basis method. The decision is made by combining the answers from the Linear Discriminant Analysis (LDA) classifier and from the Classification and Regression Trees (CART) that is also accompanied with an additional unit, called Aisles, that reduces false alarms rate. The proposed algorithm is a generic solution for process control that is based on a learning phase (training) followed by an automatic real time detection while minimizing the false alarms rate. 相似文献
1000.
We study time step restrictions due to linear stability constraints of Runge–Kutta Discontinuous Galerkin methods on triangular grids. The scalar advection equation is discretized in space by the Discontinuous Galerkin method with either the Lax–Friedrichs flux or the upwind flux, and integrated in time with various Runge–Kutta schemes designed for linear wave propagation problems or non-linear applications. Von–Neumann-like analyses are performed on structured periodic grids made up of congruent elements, to investigate the influence of element shape on the stability restrictions. We assess CFL conditions based on different element size measures, among which only the radius of the inscribed circle and the shortest height prove appropriate, although they are not totally independent of the triangle shape. We explain their general behaviour with respect to element quality, and report the corresponding Courant numbers with both types of flux and polynomial order p ranging from 1 to 10, for use as guidelines in practical simulations. We also compare the performance of the Lax–Friedrichs flux and the upwind flux, and we draw general conclusions about the relative computational efficiency of RK schemes. The application of CFL conditions to two examples involving respectively an unstructured and a hybrid grid confirms our results, although it shows that local stability criteria tend to yield too restrictive conditions. 相似文献