Insights on Ferroptosis and Colorectal Cancer: Progress and Updates

Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) benefit less from traditional therapies; hence, new therapeutic strategies may help improve the treatment response and prognosis of these patients. Ferroptosis is an iron-dependent type of regulated cell death characterized by the accumulation of lipid reactive oxygen species (ROS), distinct from other types of regulated cell death. CRC cells, especially those with drug-resistant properties, are characterized by high iron levels and ROS. This indicates that the induction of ferroptosis in these cells may become a new therapeutic approach for CRC, particularly for eradicating CRC resistant to traditional therapies. Recent studies have demonstrated the mechanisms and pathways that trigger or inhibit ferroptosis in CRC, and many regulatory molecules and pathways have been identified. Here, we review the current research progress on the mechanism of ferroptosis, new molecules that mediate ferroptosis, including coding and non-coding RNA; novel inducers and inhibitors of ferroptosis, which are mainly small-molecule compounds; and newly designed nanoparticles that increase the sensitivity of cells to ferroptosis. Finally, the gene signatures and clusters that have predictive value on CRC are summarized.     

Surface Bundles with Nonvanishing Signature

Using the theory of Lefschetz fibrations and recent advances in mapping class group theory, surface bundles over surfaces with nonzero signature and small base genus are constructed. In particular, a genus-5 fibration over the surface of genus 26 with nonzero signature is given –- improving former results on the possible base genera for surface bundles over surfaces with nonzero signature.     

大型精密仪器的在线测试维修技术

本文概述了国内外大型智能仪器维修工作的现场在线测试方法,介绍了各种主要新技术及方法的特点,谈了实际工作中的一些体会和看法,强调了在维修工作中采用新技术、新设备的重要性。     

Rb晕带signature反转的机理

将角动量投影壳模型应用到84Rb核，对组态为πg9/2νg9/2的正宇称晕带和组态为π(p3/2,f5/2)νg9/2的负宇称晕带理论计算和实验结果进行了比较，特别是对正宇称晕带中的signature反转机理进行了探讨.角动量投影壳模型计算显示正宇称晕带中的signature反转是原子核随自旋增加形状发生变化的信号，其间原子核从低自旋的长椭球通过三轴形变变到高自旋的扁椭球.此外，还确定了此两带的原子核形状.     

Characterization of minimal elements in minimization problems with constraints

LetX be a compact Hausdorff space andC(X) be the set of all continuous functions defined onX. LetVC(X), and consider the problem of minimizing sup _xX W[x,v(x)], withvV. The functionW is a generalized weight function and can be chosen such that certain constraints are included.The notions of critical point and extremal signature are used to formulate characterization theorems for a minimal element inV. It is shown that these theorems hold only under certain conditions ofV andW. The results obtained are applied to the problem of the Chebyshev approximation with constraints and to the problem of optimization with strictly quasiconvex constraints.The work of the second author was supported in part by the Alexander von Humboldt Stiftung and the DAAD.     

用双滤波反馈半导体激光器产生低延时特征的混沌信号

将两个法布里-珀罗干涉仪作为双外腔构成双滤波反馈半导体激光器,获取低延时特征混沌信号,理论研究了反馈时间、反馈强度、滤波器带宽以及滤波器中心频率与激光器中心频率之间的频率失谐对双滤波反馈半导体激光器混沌输出延时特征的影响.研究结果表明:当两个腔的反馈延迟时间之差约等于激光器弛豫振荡周期的一半时,输出混沌信号的延时特征抑制效果相对较好.在此基础上,通过合理选择反馈强度、滤波器带宽、滤波器中心频率与激光器中心频率之间的频率失谐,双滤波反馈半导体激光器输出混沌信号的延时特征被进一步抑制.最后,绘制混沌延时特征在滤波器带宽和频率失谐构成的参量空间的分布图,确定获取低延时特征的混沌信号所需的反馈参量范围.     

Construction of k-Angle Tight Frames

Frames have become standard tools in signal processing due to their robustness against transmission errors and their resilience to noise. Equiangular tight frames (ETFs) are particularly useful and have been shown to be optimal for transmission under a certain number of erasures. Unfortunately, ETFs do not exist in many cases and are hard to construct when they do exist. However, it is known that an ETF of d + 1 vectors in a d dimensional space always exists. This article gives an explicit construction of ETFs of d + 1 vectors in a d dimensional space. This construction works for both real and complex cases and is simpler than existing methods. The absence of ETFs of arbitrary sizes in a given space leads to generalizations of ETFs. One way to do this to consider tight frames where the set of (acute) angles between pairs of vectors has k distinct values. This article presents a construction of tight frames such that for a given value of k, the angles between pairs of vectors take at most k distinct values. These tight frames can be related to regular graphs and association schemes.     

两个无证书签名方案的分析与改进

无证书密码体制结合了基于身份密码体制和传统公钥密码体制的优点,受到了密码和信息安全研究者的极大关注.对梁景玲等提出的消息可恢复的无证书签名方案和侯红霞等提出的无证书短签名方案进行安全性分析,发现两个方案都不能抵抗公钥替换攻击.通过修改签名者密钥生成算法,增加对用户公钥的有效性验证,提高了梁等方案的安全性.通过在签名阶段将用户公钥绑定进HaSh函数,弥补了侯等方案的安全缺陷.     

MALDI-TOF mass signatures for differentiation of yeast species,strain grouping and monitoring of morphogenesis markers

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is demonstrated to be a potentially useful tool for the rapid identification of yeasts, the grouping of Candida albicans strains, and the monitoring of germ tube-specific markers. Co-crystallized with sinapinic acid as the MALDI matrix, intact yeast cells yielded a sufficient number of medium-sized ions (4–15 kDa) in MALDI mass spectra to provide “mass signatures” that were diagnostic of strain type. For most isolates, the mass signatures were affected by the growth medium, length of incubation and the cell preparation method. While the overall past success of this methodology for fungal cells has been relatively low compared to its application to bacteria, fixing the yeast cells in 50% methanol inactivated the cells, reduced cell aggregation in aqueous suspension solution, and more importantly, it significantly improved the mass signature quality. This simple but critical advance in sample treatment improved mass spectrometric signal-to-noise ratios and allowed the identification of yeasts by a mass signature approach. Under optimized conditions, Candida species (C. albicans, C. glabrata, C. krusei, C. kefyr), Aspergillus species (A. terreus, A. fumigatus, A. syndowii) and other yeast genera (Cryptococcus neoformans, Saccharomyces cerevisiae and a Rhodotorula sp.) could be distinguished. Within the C. albicans species, several common ions in the m/z 5,000–10,000 range were apparent in the mass spectra of all tested strains. In addition to shared ions, the mass spectra of individual C. albicans strains permitted grouping of the strains. Principal component analysis (PCA) was employed to confirm spectral reproducibility and C. albicans strain grouping by mass signatures. Finally, C. albicans germ tubes produced MALDI-TOF mass signatures that differed from yeast forms of this species. This is a rapid, sensitive and simple method for identifying yeasts, grouping strains and following the morphogenesis of C. albicans. Figure