The solubility of bosentan in aqueous-2-propanol mixtures at several temperatures,measurement and data correlation

ABSTRACT

The solubilities of bosentan (BST) in binary aqueous mixtures of 2-propanol at temperatures ranging from 293.15 to 313.15 K were determined using a shake-flask method. The produced data were modelled with the Jouyban-Acree-van’t Hoff model and difference between the predicted data and experimental ones were illustrated by percent average relative deviations (%ARD). Moreover, the thermodynamic functions of dissolution for BST in the aqueous 2-propanol solutions were computed which suggest that the dissolution process is endothermic and not spontaneous.     

Brownian motion on a manifold

The question of the existence and correct form of equations describing Brownian motion on a manifold cannot be answered by mathematics alone, but requires a study of the underlying physics. As in classical mechanics, manifolds enter through the transformation of variables needed to account for the presence of constraints. The constraints are either due to a physical agency that forces the motion to remain on a manifold, or they represent conserved quantities of the equation of motion themselves. Also the Brownian motion is described either by a Smoluchowski diffusion equation or by a Kramers equation. The four cases lead to the following conclusions, (i) Smoluchowski diffusion with a conserved quantity reduces to a diffusion equation on the manifold; (ii) The same is true for diffusion with a physical constraint in three dimensions, but in more dimensions it may happen thatno autonomous equation on the manifold results; (iii) A Kramers equation with a conserved quantity reduces to an equation on the manifold, but in general not of the form of a Kramers equation; (iv) The Kramers equation with a physical constraint reduces to an autonomous Kramers equation on the manifold only for a special shape of that constraint. Throughout, only a certain type of physical constraints has been envisaged, and global questions are ignored. Finally, the customary heuristic construction of a Fokker-Planck equation for a mechanical system on a manifold is demonstrated for the case of Brownian rotation of a rigid body, and its shortcomings are emphasized.     

Realization of a unique time evolution unitary operator in Klein Gordon theory

The scattering theory for the Klein Gordon equation, with time-dependent potential and in a non-static space-time, is considered. Using the Klein Gordon equation formulated in the Hubert spaceL ²(R ³) and the Einstein’s relativistic equation in the spaceL ²(R ³, dx) and establishing the equivalence of the vacuum states of their linearized forms in the Hubert spaceL ²(R ³) with the help of unique symmetric symplectic operator, the time evolution unitary operatorU(t) has been fixed for the Klein Gordon equation, incorporating either the positive or negative frequencies, in the infinite dimensional Hubert spaceL ²(R ³).     

Nucleon octet in a relativistic logarithmic potential

A simple independent-quark-model based on the Dirac equation with logarithmic potential is used to calculate several properties of octet baryons such as magnetic moment, the axial vector coupling constantg _A (n) for neutronβ-decay and the charge radius of the proton. In view of the simplicity of the model, the results obtained are quite good.     

On the initial layer solution of the Boltzmann equation with small Knudsen number

We extend our method of systematic removal of secular terms in a singular perturbation treatment of the Boltzmann equation with small Knudsen numbers to the initial layer. The requirement that the solution through the initial layer should connect smoothly to the normal solution removes an ambiguity noted in our previous paper. We show that removal of secular terms improves Grad's solution for the initial layer and reintroduces soundlike modes associated with higher moments, first found by Wang Chang and Uhlenbeck.     

Stationary velocity distribution in an external field: A one-dimensional model

The velocity distribution of a charged hard rod coupled to an external field and moving in a neutral equilibrium hard rod gas is studied on the basis of Boltzmann's equation. The exact stationary solution is found. Above a threshold value the field becomes effective in the high-velocity region slowing down the decay of the velocity distribution. The drift velocity and the mean kinetic energy are discussed as functions of the field.     

Resonant response of a thermalized ensemble of nonlinear oscillators

The analysis is carried out of the response of the center of gravity (dipole moment) of the distribution of noninteracting thermalized nonlinear oscillators to a sinusoidal driving force. Heat bath coupling is modeled by damping and noise. The driving is weak, but the frequency is resonant, so that there is a nonlinear resonance in the phase space. The response has a linear part that can be obtained from the perturbation analysis and a small nonlinear correction that is specific for the resonant structure.     

丢番图方程1/w＋1/x＋1/y＋1/z＋1/wxyz＝0的一种解法

本文用初等方法研究丢番图方程的整数解问题。证明了时任何非零整数ｗ，方程总有解，只要ｗ．ｘ给定，即可用公式求出方程的一切解．     

Enhancement of activated decay of metastable states by resonant pumping

We consider the effect of a high-frequency pumping cost on the escape rate of a classical underdamped Brownian particle out of a deep potential well. The energy dependence of the oscillation frequency(E) is assumed to be weak on the scale of thermal energy,_E(0)T(0)T/V₀ (0)[_E(0) is the derivative of(E) atE= 0,V ₀ is the barrier height,V ₀ T]. The quadratic-in- contribution to the decay rate is calculated in two different regimes: (1) for the case of resonance of the pumping frequency with the nth harmonic of the internal motion at an energye, when = n(e); (2) for a rollout region of the basic resonance near the bottom of the potential well, when ¦-(0)¦ and is the damping coefficient. In the latter case the absorption spectrum and the enhancement of the decay rate are calculated as functions of two reduced parameters, the anharmonicity of the potential,v _E (0)T/, and the resonance mismatch, [ —(0)]/. It is shown that the effect of the pumping increases with diminishing ¦v¦ and at small v is proportional tov ^–1. In this regime, the dependence on is stepwise: the pumping contribution is large for v > 0 and small for v < 0. In the frame of our theory, the decay rate is invariant against the simultaneous alternation of the signs of andv. The spectrum of the energy absorption has the standard Lorentzian shape in the absence of anharmonicity,v=0, and with increasing of ¦v¦ shifts and widens retaining its bell-shape form.     

具有非线性阻尼的记忆型抽象发展方程的时间依赖吸引子

运用时间依赖空间中的过程理论和收缩函数方法以及更多细节性估计,研究了具有非线性阻尼和衰退记忆的抽象发展方程的解在时间依赖空间中的渐近性态,证明了时间依赖吸引子在空间E_t^{\theta }中的存在性。