基于元胞自动机的行人和机动车相互干扰机理研究

在行人流量大的人行横道处,机动车和行人之间存在较为严重的干扰.通过引入行人和机动车的冲突干扰规则, 构建了能够刻画人行横道处机动车和行人相互干扰行为的元胞自动机模型.通过数值模拟研究了行人到达率、机动车到达率、 行人冒险穿越机动车道的阈值以及行人对机动车敏感系数等因素对机动车和行人流量的影响. 模拟结果显示,所提出的模型很好地反映了行人与机动车之间的干扰特性;随着行人冒险穿越机动车道的阈值的增加, 机动车流量增大,行人流量减小;随着行人对机动车敏感系数的增加,行人避让概率减小,机动车流量减小,行人流量增大. 所得结果对混合交通的控制和管理具有一定的指导意义.     

Three-dimensional numerical simulations of cellular jet diffusion flames

Recent experimental investigations have demonstrated that the appearance of particular cellular states in circular non-premixed jet flames significantly depends on a number of parameters, including the initial mixture strength, reactant Lewis numbers, and proximity to the extinction limit (Damköhler number). For CO₂-diluted H₂/O₂ jet diffusion flames, these studies have shown that a variety of different cellular patterns or states can form. For given fuel and oxidizer compositions, several preferred states were found to co-exist, and the particular state realized was determined by the initial conditions. To elucidate the dynamics of cellular instabilities, circular non-premixed jet flames are modeled with a combination of three-dimensional numerical simulation and linear stability analysis (LSA). In both formulations, chemistry is described by a single-step, finite-rate reaction, and different reactant Lewis numbers and molecular weights are specified. The three-dimensional numerical simulations show that different cellular flames can be obtained close to extinction and that different states co-exist for the same parameter values. Similar to the experiments, the behavior of the cell structures is sensitive to (numerical) noise. During the transient blow-off process, the flame undergoes transitions to structures with different number of cells, while the flame edge close to the nozzle oscillates in the streamwise direction. For conditions similar to the experiments discussed, the LSA results reveal various cellular instabilities, typically with azimuthal wavenumber m = 1–6. Consistent with previous theoretical work, the propensity for the cellular instabilities is shown to increase with decreasing reactant Lewis number and Damköhler number.     

Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized,placebo-controlled P MRS study

Randomized, placebo-controlled single blinded study was carried out to evaluate the effect of oral creatine supplementation on cellular energetics, manual muscle test (MMT) score and functional status in steroid-naive, ambulatory boys suffering with Duchenne muscular dystrophy (DMD; n=33). Eighteen patients received creatine monohydrate (Cr; 5 g/day for 8 weeks), while 15 received placebo (500 mg of vitamin C). Phosphorus metabolite ratios were determined from the right calf muscle of patients using phosphorus magnetic resonance spectroscopy (³¹P MRS) both prior to (baseline) and after supplementation of Cr or placebo. In addition, metabolite ratios were determined in normal calf muscle of age and sex matched controls (n=8). Significant differences in several metabolite ratios were observed between controls and DMD patients indicating a lower energy state in these patients. Analysis using analysis of covariance adjusted for age and stature showed that the mean phosphocreatine (PCr)/inorganic phosphate (Pi) ratio in patients treated with Cr (4.7; 95% CI; 3.9–5.6) was significantly higher (P=.03) compared to the placebo group (3.3; 95% CI; 2.5–4.2). The mean percentage increase in PCr/Pi ratio was also more in patients <7 years of age compared to older patients after Cr supplementation indicating variation in therapeutic effect with the age. In the placebo group, significant reduction in PCr/Pi (P=.0009), PCr/t-ATP (P=.05) and an increase in phosphodiester (PDE)/PCr ratios was observed after supplementation. Further, in the placebo group, patients <7 years showed reduction of PCr/t-ATP and Pi/t-ATP compared to older patients (>7 years), after supplementation. These results imply that the significant difference observed in PCr/Pi ratio between the Cr and the placebo groups after supplementation may be attributed to a decrease of PCr in the placebo group and an increase in PCr in the Cr group. Changes in MMT score between the two groups was significant (P=.04); however, no change in functional scale (P=.19) was observed. Parents reported subjective improvement on Cr supplementation versus worsening in placebo (P=.02). Our results indicated that Cr was well tolerated and oral Cr significantly improved the muscle PCr/Pi ratio and preserved the muscle strength in short term. However, this study provides no evidence that creatine will prove beneficial after long-term treatment, or have any positive effect on patient lifespan.     

中小学门口道路上学期间的一个元胞自动机模型

在已有交通流道路瓶颈、交织区和混合交通流研究的基础上,建立一个中小学门口道路区段上学期间的元胞自动机模型,对上学期间的道路交通流特性进行了模拟,对驾私家车送学生上学比例、乘校车上学比例和交警现场指挥对道路交通流的影响进行实验分析.模拟结果表明减少驾车送学生上学比例、增加乘校车学生比例、辅助以交警现场指挥,可保证交通安全,从而达到抑制交通拥堵、减少车辆总通行时间提高道路实际通行能力的目的.     

Ultrasound induces cellular destruction of nasopharyngeal carcinoma cells in the presence of curcumin

Objectives

Curcumin, a natural pigment from the traditional Chinese herb, has shown promise as an efficient enhancer of ultrasound. The present study aims to investigate ultrasound-induced cellular destruction of nasopharyngeal carcinoma cells in the presence of curcumin in vitro.

Methods

Nasopharyngeal carcinoma cell line CNE2 cells were incubated by 10 μm curcumin and then were treated by ultrasound for 8 s at the intensity of 0.46 W/cm². Cytotoxicity was evaluated using MTT assay and light microscopy. Mitochondrial damage was analyzed using a confocal laser scanning microcopy with Rhodamine 123 and ultrastructural changes were observed using a transmission electron microscopy (TEM).

Results

MTT assay showed that cytotoxicity induced by ultrasound treatment alone and curcumin treatment alone was 18.16 ± 2.37% and 24.93 ± 8.30%, respectively. The cytotoxicity induced by the combined treatment of ultrasound and curcumin significantly increased up to 86.67 ± 7.78%. TEM showed that microvillin disappearance, membrane blebbing, chromatin condensation, swollen mitochondria, and mitochondrial myelin-like body were observed in the cells treated by ultrasound and curcumin together. The significant collapse of mitochondrial membrane potential (MMP) was markedly observed in the CNE2 cells after the combined treatment of curcumin and ultrasound.

Conclusions

Our findings demonstrated that ultrasound sonication in the presence of curcumin significantly killed the CNE2 cells and induced ultrastructural damage and the dysfunction of mitochondria, suggesting that ultrasound treatment remarkably induced cellular destruction of nasopharyngeal carcinoma cells in the presence of curcumin.     

Calculation of critical properties for the anisotropic two-layer Ising model on the Kagome lattice: Cellular automata approach

The critical point (K_c) of the two-layer Ising model on the Kagome lattice has been calculated with a high precision, using the probabilistic cellular automata with the Glauber algorithm. The critical point is calculated for different values of the inter- and intra-layer couplings (K₁≠K₂≠K₃≠K_z), where K₁, K₂ and K₃ are the nearest-neighbor interactions within each layer in the 1, 2 and 3 directions, respectively, and K_z is the intralayer coupling. A general ansatz equation for the critical point is given as a function of the inter- and intra-layer interactions, ξ=K₃/K₁,σ=K₂/K₁ and ω=K_z/K₁ for the one- and two-layer Ising models on the Kagome lattice.     

On Cesàro Limit Distribution of a Class of Permutative Cellular Automata

We study Cesàro means (time averages) of the evolution measures of the class of permutative cellular automata over {0, 1} defined by % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGaaiikaiabew% 9aQnaaBaaaleaacaWGcbaabeaakiaadIhacaGGPaWaaSbaaSqaaiaa% d6gaaeqaaOGaeyypa0JaamiEamaaBaaaleaacaWGUbGaaGjcVlaayI% W7cqGHRaWkcaaMi8UaaGjcVlaadkfaaeqaaOGaey4kaSIaeuiOda1a% a0baaSqaaiaadQgacaaMi8UaaGjcVlabg2da9iaayIW7caaMi8UaaG% imaaqaaiaadkfacaaMi8UaaGjcVlabgkHiTiaayIW7caaMi8UaaGym% aaaakiaayIW7caaMi8UaaGjcVlaayIW7caaMi8UaaGjcVlaacIcaca% aIXaGaey4kaSIaamOyamaaBaaaleaacaWGQbaabeaakiabgUcaRiaa% dIhadaWgaaWcbaGaamOBaiaayIW7caaMi8Uaey4kaSIaaGjcVlaayI% W7caWGQbaabeaakiaacMcaaaa!7530! $$(\varphi _B x)_n = x_{n{\kern 1pt} {\kern 1pt} + {\kern 1pt} {\kern 1pt} R} + \Pi _{j{\kern 1pt} {\kern 1pt} = {\kern 1pt} {\kern 1pt} 0}^{R{\kern 1pt} {\kern 1pt} - {\kern 1pt} {\kern 1pt} 1} {\kern 1pt} {\kern 1pt} {\kern 1pt} {\kern 1pt} {\kern 1pt} {\kern 1pt} (1 + b_j + x_{n{\kern 1pt} {\kern 1pt} + {\kern 1pt} {\kern 1pt} j} )$$ where B=b ₀ b _R-1is an aperiodic block in {0, 1} ^R and operations are taken mod 2. If the initial measure is Bernoulli, we prove that the limit of the Cesàro mean of the first column distribution exists. When R = 1 and B = 1, _B is the mod 2 sum automaton. For this automaton we show that the limit is the (1/2, 1/2(-Bernoulli measure, and if the initial measure is Markov, we show that the limit of Cesàro mean of the one-site distribution is equidistributed.     

Bridging the gap: From cellular automata to differential equation models for pedestrian dynamics

Cellular automata (CA) and ordinary differential equation (ODE) models compete for dominance in microscopic pedestrian dynamics. There are two major differences: movement in a CA is restricted to a grid and navigation is achieved by moving directly in the desired direction. Force based ODE models operate in continuous space and navigation is computed indirectly through the acceleration vector. We present the Optimal Steps Model and the Gradient Navigation Model, which produce trajectories similar to each other. Both are grid-free and free of oscillations, leading to the conclusion that the two major differences are also the two major weaknesses of the older models.     

Fuzzy正则表达式与Fuzzy有限态自动机的关系

首先给出了Fuzzy正则表达式的定义,接着通过研究Fuzzy正则表达式与Fuzzy有限态自动机的关系,得到了两个重要性质,即：每一个Fuzzy正则表达式,都有一个非确定性的Fuzzy有限态自动机接受其代表的语言;每一个被确定性的Fuzzy有限态自动机接受的语言,都能被一个Fuzzy正则表达式表示．     

22号初等元胞自动机的演化复杂性

Cellular automata are the discrete dynamical systems of simple construction but with complex and varied behaviors. In this paper, the elementary cellular automaton of rule 22 is studied by the tools of formal language theory and symbolic dynamics. Its temporal evolution orbits are coarse-grained into evolution sequences and the evolution languages are defined. It is proved that for every n≥2 its width n evolution language is not regular.