利用光敏光纤制作少模光纤布喇格光栅

利用相位掩模技术在光敏光纤中制作出了少模光纤布喇格光栅,1.06μm波长附近有2~3个特征峰,峰值约4~5 dB.对这种光纤光栅的特性进行了分析,结果表明理论与实验结果符合得较好,并对光纤光栅的温度特性进行了实验研究和理论分析,实验结果测得光纤光栅的温度敏感度为9~10 pm/℃.     

当量溶液分光光度法同时测定微量钙和镁

采用当量溶液法对钙、镁进行光度分析 ,研究了酸性铬兰 K与 (1+ 1)钙、镁混合体系的显色条件 ,在不经分离和掩蔽的条件下同时测定出钙、镁离子含量。方法简单、准确 ,对水样进行分析 ,结果令人满意     

对固体圆二色光谱测试方法的再认识——兼谈“浓度效应”

对近期发展的固体圆二色(CD)光谱测试方法进行了概述、评价和比较, 着重探讨了“浓度效应”的存在使固体CD光谱失真的原因. 通过对本课题组和其他作者已报道的四种化合物的固体CD谱再测试的反思, 强调了依手性化合物的手性光谱学性质不同, 根据浓度梯度实验选择其合适测试浓度的必要性. 对固有手性的阻转异构化合物(S)-1,1'-联二萘酚(S-BINOL)进行了成膜法固体CD谱浓度梯度测试, 发现所得固体薄膜CD谱中也存在着“浓度效应”     

Determination of the residual ethanol in hydroalcoholic sealed hard gelatin capsules by static headspace gas chromatography with immiscible binary solvents

Static headspace gas chromatography (HS-GC) with immiscible binary solvents is described to quantitatively determine the residual ethanol used to seal the hard gelatin capsules by liquid encapsulated and microspray sealing (LEMS; cfs 1200, Greenwood, SC, USA). The effects of decane, dodecane, heptane, 0.1 M HCl, N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidinone and dimethyl sulfoxide on the method sensitivity are compared. It is observed that the ethanol headspace concentrations can be increased by fourfolds when aliphatic hydrocarbon solvents are added into the aqueous sample solutions in a HS vial. In addition, a mathematic model based on the concentration equilibriums of liquid–liquid and liquid–gas phases is derived to quantitatively describe the ethanol headspace concentrations versus the volumes of the aliphatic hydrocarbon solvents. The proposed model fits well to the experimental data. The impacts of the oven temperatures and vial equilibration times on the ethanol headspace concentrations are also investigated. Furthermore, the potential interferences of the capsule placebo and hard gelatin capsule shells on the selectivity and quantitation of the method are discussed. The linearity is validated from 5 μg/mL to 500 μg/mL. The limit of quantitation is 5 μg/mL. The accuracy is determined to be 100.8 ± 6%. Finally, this method is successfully used to determine the residual ethanol in the sealed capsules of 5 mg and 10 mg developmental Drug A, and 100 mg and 200 mg developmental Drug B.     

A confirmatory method for the simultaneous extraction,separation, identification and quantification of Tetracycline,Sulphonamide, Trimethoprim and Dapsone residues in muscle by ultra-high-performance liquid chromatography–tandem mass spectrometry according to Commission Decision 2002/657/EC

A rapid confirmatory multi-residue method for the analysis of tetracyclines, sulphonamides, trimethoprim and dapsone by UPLC-MS/MS is described. The method is able to quantify and confirm the following 19 compounds, oxytetracycline, tetracycline, chlortetracycline, doxycycline, sulfadiazine, sulfathiazole, sulfapyridine, trimethoprim, sulfamerazine, sulfamethizole, sulfamethazine, sulfamethoxypyridazine, sulfamonomethoxine, sulfachlorpyridazine, dapsone, sulfamethoxazole, sulfisoxazole, sulfaquinoxaline and sulfadimethoxine. Samples are extracted with 0.1 M EDTA and acetonitrile, which is then evaporated under a stream of nitrogen and reconstituted in water. Following centrifugation and filtering, an aliquot is analysed by UPLC-MS/MS using positive electrospray ionisation and multiple reaction monitoring. The method is deemed rapid as all analytes are extracted by a single extraction technique, with no solid-phase extraction clean up required. Validation is according to Commission Decision 2002/657/EC and was carried out for bovine, porcine, ovine and poultry species. Specificity, recovery, repeatability, reproducibility, CCα and CCβ data is presented.     

Rapid confirmatory method for the determination of 11 nitroimidazoles in egg using liquid chromatography tandem mass spectrometry

A rapid confirmatory method has been developed and validated for the simultaneous identification, confirmation and quantitation of 11 nitroimidazoles in eggs by liquid chromatography tandem mass spectrometry (LC–MS/MS). The method is validated in accordance with Commission Decision 2002/657/EC and is capable of analysing metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), ipronidazole (IPZ) and their hydroxy metabolites MNZ-OH, HMMNI (hydroxymethyl, methyl nitroimidazole), IPZ-OH. The method is also capable of analysing carnidazole (CRZ), ornidazole (ORZ), tinidazole (TNZ) and ternidazole (TRZ). MNZ, DMZ and RNZ have been assigned a recommended level (RL) of 3 μg kg⁻¹ by the Community Reference Laboratory (CRL) in Berlin. The developed method described in this study is easily able to detect all the nitroimidazole compounds investigated at this level and below. Egg samples are extracted with acetonitrile, and NaCl is added to help remove matrix contaminants. The acetonitrile extract undergoes a liquid–liquid wash step with hexane; it is then evaporated and reconstituted in mobile phase. The reconstituted samples are analysed by liquid chromatography tandem mass spectrometry (LC–MS/MS). The decision limits (CCα) range from 0.33 to 1.26 μg kg⁻¹ and the detection capabilities (CCβ), range from 0.56 to 2.15 μg kg⁻¹. The results of the inter-assay study, which was performed by fortifying hen egg samples (n = 18) on three separate days, show the accuracy calculated for the various analytes to range between 87.2 and 106.2%. The precision of the method, expressed as %CV values for the inter-assay variation of each analyte at the three levels of fortification (3, 4.5 and 6.0 μg kg⁻¹), ranged between 3.7 and 11.3%. A Day 4 analysis was carried out to examine species variances in eggs from different birds such as duck and quail and investigating differences in various battery and free range hen eggs.     

聚合物合成工艺学课程教学初探

聚合物合成工艺学是高分子专业重要的课程,通过工艺学课程的内容和特点的研究,对工艺学的重点和采用的教学方法进行了初步探讨.认为课程的重点在于突出聚合过程、技术和工程,通过对聚乙烯、聚碳酸酯、聚氨酯、聚对苯二甲酸二乙酯和丁苯橡胶等典型聚合的介绍,使学生了解聚合物合成工艺学的基本内容.除了做到掌握教学重点外,还应调动自身与发挥学生主动性、理论结合实际、参观生产工厂等方法结合,教学取得了良好的效果.     

Efficient implementation of the MFS: The three scenarios

In this study we investigate the approximation of the solutions of harmonic problems subject to Dirichlet boundary conditions by the Method of Fundamental Solutions (MFS). In particular, we study the application of the MFS to Dirichlet problems in a disk. The MFS discretization yields systems which possess special features which can be exploited by using Fast Fourier transform (FFT)-based techniques. We describe three possible formulations related to the ratio of boundary points to sources, namely, when the number of boundary points is equal, larger and smaller than the number of sources. We also present some numerical experiments and provide an efficient MATLAB implementation of the resulting algorithms.     

三角模糊数判断矩阵理论及排序方法研究

由于三角模糊数运算的复杂性和特殊性,许多经典判断矩阵的理论并非完全适用于三角模糊数判断矩阵.首先指出目前文献中三角模糊数判断矩阵排序向量研究中存在的问题,并对经典判断矩阵的理论和性质在三角模糊数中是否完全适用进行了证明,然后基于已经证明在三角模糊数判断矩阵所适用的性质,分别建立了最小二乘法的三角模糊数互反互补判断矩阵目标优化模型,通过求解其模型可得到矩阵的权重向量,最后利用已有的三角模糊数排序公式求得决策结果.算例分析验证了该方法的正确性和有效性.     

基于蕴涵算子族L-λ-R0的模糊推理反向α-三I约束算法

提出了基于蕴涵算子族L-λ-R0的模糊推理的思想,这将有助于提高推理结果的可靠性.针对蕴涵算子族L-λ-R0给出了模糊推理的FMP模型及FMT模型的反向α-三I约束算法.