全文获取类型
收费全文 | 6935篇 |
免费 | 211篇 |
国内免费 | 504篇 |
专业分类
化学 | 6568篇 |
晶体学 | 61篇 |
力学 | 79篇 |
综合类 | 19篇 |
数学 | 566篇 |
物理学 | 357篇 |
出版年
2024年 | 11篇 |
2023年 | 51篇 |
2022年 | 170篇 |
2021年 | 156篇 |
2020年 | 144篇 |
2019年 | 159篇 |
2018年 | 136篇 |
2017年 | 173篇 |
2016年 | 153篇 |
2015年 | 125篇 |
2014年 | 179篇 |
2013年 | 575篇 |
2012年 | 238篇 |
2011年 | 226篇 |
2010年 | 179篇 |
2009年 | 246篇 |
2008年 | 274篇 |
2007年 | 302篇 |
2006年 | 246篇 |
2005年 | 259篇 |
2004年 | 260篇 |
2003年 | 249篇 |
2002年 | 1741篇 |
2001年 | 211篇 |
2000年 | 135篇 |
1999年 | 111篇 |
1998年 | 88篇 |
1997年 | 100篇 |
1996年 | 94篇 |
1995年 | 109篇 |
1994年 | 75篇 |
1993年 | 75篇 |
1992年 | 70篇 |
1991年 | 42篇 |
1990年 | 28篇 |
1989年 | 22篇 |
1988年 | 33篇 |
1987年 | 27篇 |
1986年 | 17篇 |
1985年 | 21篇 |
1984年 | 25篇 |
1983年 | 6篇 |
1982年 | 15篇 |
1981年 | 9篇 |
1980年 | 13篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1973年 | 3篇 |
1971年 | 32篇 |
1970年 | 16篇 |
排序方式: 共有7650条查询结果,搜索用时 15 毫秒
881.
二茂铁是合成新颖有机功能材料的基本单元之一。 本文设计并合成了两个基于二茂铁的同分异构查尔酮衍生物:1-二茂铁基-3-(噻吩-2-基)丙烯酮(a)和1-二茂铁基-3-(噻吩-3-基)丙烯酮(b)。 采用超快激光Z-扫描技术(脉宽180 fs,波长532 nm)测定了化合物a和b的三阶非线性光学性质。 结果表明,化合物a吸收系数β=-2.1×10-12 m/W,折射率n2=1.9×10-19 m2/W,分子超极化率γ=5.37×10-32 esu;化合物b:β=-1.2×10-13 m/W,n2=2.0×10-19 m2/W,γ=4.48×10-32 esu。 说明在飞秒激光激发下,电荷转移能够在化合物a和b分子内部快速进行,二者均具有优异的超快三阶非线性光学响应。 在B3LYP/6-311+G(d,p)理论水平下,计算了化合物a和b分子轨道能量、极化率和各基团在前线分子轨道中的占有率。 理论计算结果显示,二茂铁基团在化合物a和b前线分子轨道中占有率分别为97%和98%,对两化合物的非线性光学性能起主导作用。 相似文献
882.
Infrared Photodissociation Spectroscopic and Theoretical Study of the HC2nO+ (n=3-6) Cations 下载免费PDF全文
The carbon chain cations, HC2nO+ (n=3-6) are produced via a pulsed laser vaporization supersonic expansion ion source in the gas phase. Their infrared spectra are measured via mass-selected infrared photodissociation spectroscopy of the CO “tagged” [HC2nO·CO]+ cation complexes in 1600-3500 cm-1 frequency range. The geometric and electronic structures of the [HC2nO·CO]+ complexes and the core HC2nO+ (n=3-6) cations are determined with the aid of density functional theory calculations. These HC2nO+(n=3-6) ions are identified to be linear carbon chain derivatives terminally capped by hydrogen and oxygen. The triplet ground states are 10-15 kcal/mol lower in energy than the singlet states, indicating cumulene-like carbon chain structures. 相似文献
883.
《Comptes Rendus Chimie》2019,22(4):316-320
The voltammetric oxidation of five para-substituted acetophenone derivatives (containing nitro, chloro, bromo, methyl and hydroxyl groups as substituents) and that of benzophenone was studied on a platinum and glassy carbon electrode in acetonitrile media. Electrode passivation was observed in the case when all selected compounds are on a glassy carbon electrode; an oxidation peak appeared between 2.5 and 3 V. The voltammograms of 4′-hydroxyacetophenone showed an additional peak around 2 V, which may be associated with the oxidation of the phenol moiety. In the case of a platinum electrode, no relevant peaks appeared on the voltammograms, reflecting the absence of passivation. The use of a redox probe 1,4-dihydroxybenzene showed that the glassy carbon electrode, after cyclization in the solutions of the outlined compounds, has higher sensitivity towards the oxidation product (1,4-benzoquinone) of this compound. 相似文献
884.
B. BroekPuska W. Czajkowski M. Kurczewska H. Abramczyk 《Journal of Molecular Liquids》2008,141(3):140
Photochemical and photophysical behavior of the tetrasulphonated magnesium phthalocyanine MgPcS4 has been studied by Raman spectroscopy, femtosecond transient absorption, and stationary UV–VIS absorption spectroscopies. It has been shown also that the dimerization equilibrium constant K for the tetrasulfonated magnesium phthalocyanine is strongly shifted towards monomeric form in DMSO solutions compared to aqueous systems. The Raman and emission spectra recorded in the range of 294–77 K combined with the femtosecond transient absorption reveal spectral features that provide unique information about the primary photochemical and photophysical events of magnesium phthalocyanines in liquid solutions as well as in the crystal frozen matrices. 相似文献
885.
The definition and simulation of fractional Brownian motion are considered from the point of view of a set of coherent fractional derivative definitions. To do it, two sets of fractional derivatives are considered: (a) the forward and backward and (b) the central derivatives, together with two representations: generalised difference and integral. It is shown that for these derivatives the corresponding autocorrelation functions have the same representations. The obtained results are used to define a fractional noise and, from it, the fractional Brownian motion. This is studied. The simulation problem is also considered. 相似文献
886.
Faizan Ur Rahman Maryam Bibi Ezzat Khan Abdul Bari Shah Mian Muhammad Muhammad Nawaz Tahir Adnan Shahzad Farhat Ullah Muhammad Zahoor Salman Alamery Gaber El-Saber Batiha 《Molecules (Basel, Switzerland)》2021,26(15)
In this study six unsymmetrical thiourea derivatives, 1-isobutyl-3-cyclohexylthiourea (1), 1-tert-butyl-3-cyclohexylthiourea (2), 1-(3-chlorophenyl)-3-cyclohexylthiourea (3), 1-(1,1-dibutyl)-3-phenylthiourea (4), 1-(2-chlorophenyl)-3-phenylthiourea (5) and 1-(4-chlorophenyl)-3-phenylthiourea (6) were obtained in the laboratory under aerobic conditions. Compounds 3 and 4 are crystalline and their structure was determined for their single crystal. Compounds 3 is monoclinic system with space group P21/n while compound 4 is trigonal, space group R3:H. Compounds (1–6) were tested for their anti-cholinesterase activity against acetylcholinesterase and butyrylcholinesterase (hereafter abbreviated as, AChE and BChE, respectively). Potentials (all compounds) as sensing probes for determination of deadly toxic metal (mercury) using spectrofluorimetric technique were also investigated. Compound 3 exhibited better enzyme inhibition IC50 values of 50, and 60 µg/mL against AChE and BChE with docking score of −10.01, and −8.04 kJ/mol, respectively. The compound also showed moderate sensitivity during fluorescence studies. 相似文献
887.
The purpose of this article is to investigate high‐order numerical approximations of scalar conservation laws with nonlocal viscous term. The viscous term is given in the form of convolution in space variable. With the help of the characteristic of viscous term, we design a semidiscrete local discontinuous Galerkin (LDG) method to solve the nonlocal model. We prove stability and convergence of semidiscrete LDG method in L2 norm. The theoretical analysis reveals that the present numerical scheme is stable with optimal convergence order for the linear case, and it is stable with sub‐optimal convergence order for nonlinear case. To demonstrate the validity and accuracy of our scheme, we test the Burgers equation with two typical nonlocal fractional viscous terms. The numerical results show the convergence order accuracy in space for both linear and nonlinear cases. Some numerical simulations are provided to show the robustness and effectiveness of the present numerical scheme. 相似文献
888.
A recent experiment [Angew. Chem. Int. Ed. 2017 , 56, 722–727] found that a (1 : 9) blend film of two anthracene derivatives, 2-fluorenyl-2-anthracene ( FlAnt ) and 2-anthryl-2-anthracence ( 2 A ), exhibit both efficient white light emission and high hole mobility, thus promising for organic light-emitting transistors (OLETs). Employing quantum chemistry at the polarizable continuum model (PCM) and the quantum mechanics/molecular mechanics (QM/MM) levels, we investigated the excited-state structures, optical spectra, band structure and the carrier mobility for FlAnt and 2 A from solution to aggregate phases. We suggest using the ratio of intermolecular excitonic coupling J and intramolecular excited state relaxation energy E to judge the bathochromic shift in optical emission in aggregates. For FlAnt , ρ=J/E is calculated to be less than 0.17, a critical value we identified earlier, and the spectra in solution and aggregate phases present quite similar features (blue emission). However, ρ is ∼0.5 for 2 A systems, and the calculated emission in the aggregate phase exhibits a remarkable bathochromic shift. In addition, the 0–0 emission is strongly suppressed in the herringbone stacking. These observations justify the experimental findings that (i) 2 A is blue emissive in solution but yellow-green in the aggregate phase, whereas FlAnt is always blue, and (ii) the blend of them show white emission. By using the “quantum nuclear tunneling” model we proposed earlier, we found the hole mobility for FlAnt and 2 A are 0.5 and 4.2 cm2 V−1 s−1, respectively, indicating both are good hole transport materials. 相似文献
889.
Zhong-Hui Pu Juan Liu Min Luo Qin-Mei Zhou Xiao-Fang Xie 《Natural product research》2019,33(10):1399-1405
Two new (1–2) and six known (3–8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of 3 was equivalent to aspirin. 相似文献
890.
Dr. Safaa M. Kishk Dr. Kirsty J. McLean Dr. Sakshi Sood Darren Smith Jack W.D. Evans Prof. Mohamed A. Helal Prof. Mohamed S. Gomaa Prof. Ismail Salama Prof. Samia M. Mostafa Dr. Luiz Pedro S. de Carvalho Colin W. Levy Prof. Andrew W. Munro Dr. Claire Simons 《ChemistryOpen》2019,8(7):995-1011
The emergence of untreatable drug-resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450 CYP121A1 is a promising drug target for the treatment of tuberculosis owing to its essential role in mycobacterial growth. Using a rational approach, which includes molecular modelling studies, three series of azole pyrazole derivatives were designed through two synthetic pathways. The synthesized compounds were biologically evaluated for their inhibitory activity towards M. tuberculosis and their protein binding affinity (KD). Series 3 biarylpyrazole imidazole derivatives were the most effective with the isobutyl ( 10 f ) and tert-butyl ( 10 g ) compounds displaying optimal activity (MIC 1.562 μg/mL, KD 0.22 μM ( 10 f ) and 4.81 μM ( 10 g )). The spectroscopic data showed that all the synthesised compounds produced a type II red shift of the heme Soret band indicating either direct binding to heme iron or (where less extensive Soret shifts are observed) putative indirect binding via an interstitial water molecule. Evaluation of biological and physicochemical properties identified the following as requirements for activity: LogP >4, H-bond acceptors/H-bond donors 4/0, number of rotatable bonds 5–6, molecular volume >340 Å3, topological polar surface area <40 Å2. 相似文献