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51.
52.
KOU S.C. 《中国科学A辑(英文版)》2009,52(6):1181-1211
Advances in nanotechnology enable scientists for the first time to study biological processes on a nanoscale molecule-by-molecule
basis. They also raise challenges and opportunities for statisticians and applied probabilists. To exemplify the stochastic
inference and modeling problems in the field, this paper discusses a few selected cases, ranging from likelihood inference,
Bayesian data augmentation, and semi- and non-parametric inference of nanometric biochemical systems to the utilization of
stochastic integro-differential equations and stochastic networks to model single-molecule biophysical processes. We discuss
the statistical and probabilistic issues as well as the biophysical motivation and physical meaning behind the problems, emphasizing
the analysis and modeling of real experimental data.
This work was supported by the United States National Science Fundation Career Award (Grant No. DMS-0449204) 相似文献
53.
This paper examines the extent to which financial returns on market indices exhibit mean and volatility asymmetries, as a response to past information from both the U.S. market and the local market itself. In particular, we wish to assess the asymmetric effect of a combination of local and U.S. market news on volatility. To the best of the authors knowledge, this joint effect has not been considered previously. We propose a double threshold non‐linear heteroscedastic model, combined with a GJR‐GARCH effect in the conditional volatility equation, to capture jointly both mean and volatility asymmetric behaviours and the interactive effect of U.S. and local market news. In an application to five major international market indices, clear evidence of threshold non‐linearity is discovered, supporting the hypothesis of an uneven mean‐reverting pattern and volatility asymmetry, both in reaction to U.S. market news and news from the local market itself. Significant, but somewhat different, interactive effects between local and U.S. news are observed in all markets. An asymmetric pattern in the exogenous relationship between the local market and the U.S. market is also found. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
54.
P.S. Koutsourelakis 《Journal of computational physics》2009,228(17):6184-6211
This paper proposes a hierarchical, multi-resolution framework for the identification of model parameters and their spatially variability from noisy measurements of the response or output. Such parameters are frequently encountered in PDE-based models and correspond to quantities such as density or pressure fields, elasto-plastic moduli and internal variables in solid mechanics, conductivity fields in heat diffusion problems, permeability fields in fluid flow through porous media etc. The proposed model has all the advantages of traditional Bayesian formulations such as the ability to produce measures of confidence for the inferences made and providing not only predictive estimates but also quantitative measures of the predictive uncertainty. In contrast to existing approaches it utilizes a parsimonious, non-parametric formulation that favors sparse representations and whose complexity can be determined from the data. The proposed framework in non-intrusive and makes use of a sequence of forward solvers operating at various resolutions. As a result, inexpensive, coarse solvers are used to identify the most salient features of the unknown field(s) which are subsequently enriched by invoking solvers operating at finer resolutions. This leads to significant computational savings particularly in problems involving computationally demanding forward models but also improvements in accuracy. It is based on a novel, adaptive scheme based on Sequential Monte Carlo sampling which is embarrassingly parallelizable and circumvents issues with slow mixing encountered in Markov Chain Monte Carlo schemes. The capabilities of the proposed methodology are illustrated in problems from nonlinear solid mechanics with special attention to cases where the data is contaminated with random noise and the scale of variability of the unknown field is smaller than the scale of the grid where observations are collected. 相似文献
55.
This paper proposes an information retrieval (IR) model based on possibilistic directed networks. The relevance of a document w.r.t a query is interpreted by two degrees: the necessity and the possibility. The necessity degree evaluates the extent to which a given document is relevant to a query, whereas the possibility degree evaluates the reasons of eliminating irrelevant documents. This new interpretation of relevance led us to revisit the term weighting scheme by explicitly distinguishing between informative and non-informative terms in a document. Experiments carried out on three standard TREC collections show the effectiveness of the model. 相似文献
56.
57.
Individuals may have biased perceptions of health and safety risks. We conjecture perceptions of mortality risk from various risk measures using parametric and non-parametric methods. We investigate how risk perceptions are measured and what rational explanations can be found for these measures with implication for risk and solvency. 相似文献
58.
Bayesian techniques specify how to update beliefs about a variable given information on that variable or related variables. In many cases, statistical analyses also provide information about the relationship between variables, but the Borel Paradox prohibits many natural ways of updating beliefs conditioned on information about a relationship. This paper presents a method by which beliefs can be updated without violating the Borel Paradox under certain circumstances. We apply our approach to relationships specified by a statistical model (i.e., regression), and relationships described by statistical simulation. 相似文献
59.
60.
Paul Sheridan Yuichi Yagahara Hidetoshi Shimodaira 《Annals of the Institute of Statistical Mathematics》2008,60(4):747-761
We propose a scale-free network model with a tunable power-law exponent. The Poisson growth model, as we call it, is an offshoot
of the celebrated model of Barabási and Albert where a network is generated iteratively from a small seed network; at each
step a node is added together with a number of incident edges preferentially attached to nodes already in the network. A key
feature of our model is that the number of edges added at each step is a random variable with Poisson distribution, and, unlike
the Barabási–Albert model where this quantity is fixed, it can generate any network. Our model is motivated by an application
in Bayesian inference implemented as Markov chain Monte Carlo to estimate a network; for this purpose, we also give a formula
for the probability of a network under our model. 相似文献