建筑场地地震液化危害评价及地基处理

本文分析了地基失稳，计算震陷值及差异震陷等地基失效形式和液化土层的隔震作用，研究了液化指数、地基失效、液化土层隔震与多层房屋震害的关系，根据液化土的双重作用原理划分了液化危害等级，并提出了建筑场地地震液化危害评价方法和按“小震不坏，中震可修，大震不倒”的抗液化处理原则。     

Types of reasoning required in university exams in mathematics

Empirical research shows that students often use reasoning founded on copying algorithms or recalling facts (imitative reasoning) when solving mathematical tasks. Research also indicate that a focus on this type of reasoning might weaken the students’ understanding of the underlying mathematical concepts. It is therefore important to study the types of reasoning students have to perform in order to solve exam tasks and pass exams. The purpose of this study is to examine what types of reasoning students taking introductory calculus courses are required to perform. Tasks from 16 exams produced at four different Swedish universities were analyzed and sorted into task classes. The analysis resulted in several examples of tasks demanding different types of mathematical reasoning. The results also show that about 70% of the tasks were solvable by imitative reasoning and that 15 of the exams could be passed using only imitative reasoning.     

C3I系统知识库的类特征模式

在Ｃ３Ｉ系统知识库中引入了条件事件推理规则以及类与特征的概念，并给出了进行动态管理知识库的有效方法。     

Discussion on sources of uncertainty for two TLD albedo dosimetry systems in a comparison of individual monitors in a reference 241Am–Be field

Under standard conditions, several studies assess uncertainty values for individual dosimetry for photons, but seldom for neutrons. The Thermoluminescent Dosimetry Laboratory (LDT) of the Instituto de Radioproteção e Dosimetria (IRD), Brazil, has been running a neutron individual monitoring service using two different albedo monitors. This paper presents a study of the contribution of relevant sources of uncertainty for neutron dose evaluation, for both systems (called System 1 and System 2), using a reference ²⁴¹Am–Be field, at normal incidence. The combined and expanded uncertainties were calculated using GUM methodology and follows RP160 from the European Commission. This methodology was applied to calculate the uncertainties associated with the LDT assessment of neutron doses in the First Brazilian National Comparison on Measurements for Neutron Individual Monitors. The LDT participated in this comparison with its two systems, both presenting satisfactory performance. For System 1, at low neutron doses, the reproducibility of the apparent neutron dose is the more relevant source of uncertainty. However, for higher doses, the neutron calibration factor, NCF, becomes more important. For System 2, NCF is the main source of uncertainty for low and high doses. For occupational doses, the uncertainty will be much higher due to the need of additional correction factors, which depend on stray neutron field.     

Measurement uncertainty in analytical methods in which trueness is assessed from recovery assays

We propose a new procedure for estimating the uncertainty in quantitative routine analysis. This procedure uses the information generated when the trueness of the analytical method is assessed from recovery assays. In this paper, we assess trueness by estimating proportional bias (in terms of recovery) and constant bias separately. The advantage of the procedure is that little extra work needs to be done to estimate the measurement uncertainty associated to routine samples. This uncertainty is considered to be correct whenever the samples used in the recovery assays are representative of the future routine samples (in terms of matrix and analyte concentration). Moreover, these samples should be analysed by varying all the factors that can affect the analytical method. If they are analysed in this fashion, the precision estimates generated in the recovery assays take into account the variability of the routine samples and also all the sources of variability of the analytical method. Other terms related to the sample heterogeneity, sample pretreatments or factors not representatively varied in the recovery assays should only be subsequently included when necessary. The ideas presented are applied to calculate the uncertainty of results obtained when analysing sulphides in wine by HS-SPME-GC.     

Sampling conformational hyperspace: Techniques for improving completeness

Summary Three new strategies for sampling the conformation space accessible to a series of structurally diverse, flexible molecules are defined and compared to samples obtained using a fixed-grid torsion angle sampling strategy. A set of 28 potent inhibitors of angiotensin converting enzyme selected by Mayer et al. [J. Comput.-Aided Mol. Design, 1 (1987) 3] and the unrestricted active-site model proposed by Waller et al. [to be published] are used to produce a realistic experimental setting. We modified our Constrained Search algorithm [Dammkoehler et al., J. Comput.-Aided Mol. Design, 3 (1989) 3] to support these new sampling strategies, performing a series of 64 simulations (search experiments) and generating a large set of sterically allowed conformations. In each experiment, we systematically vary the internal torsion angles in each molecule using one of the sampling strategies. The common orientations of preselected functional groups thought to represent those dominating the interaction with the enzyme and presented by the set of molecules are classified and recorded for each experiment. Pairwise distances between groups are used to characterize the geometry of the common orientations. The results of each experiment, represented by a set of distance values, are compared and combined to evaluate the completeness of the conformational sampling. While no pure strategy or single search experiment was found to be adequate to fully explore the set of common sterically allowed conformations, a new sampling technique, called adaptive radial sampling, is shown to be significantly more complete than the commonly used fixed grid sampling.     

An alternative approach for charge decay measurement to assess the suitability of materials

A method of charge decay testing is proposed in which a localized electric field is applied by a fieldmeter to an area of the material to be tested. The variation of electric field is recorded as charge migrates across the surface. Arrangements are described for this method of testing and studies reported comparing results with corona and tribocharge decay measurements. Interesting differences are shown between the methods of testing.Induction charge decay testing is not proposed as a replacement for corona or tribocharge decay testing. It offers the opportunity for simpler instrumentation and measurement of faster charge decay times.     

Reliability of pitch discrimination of vowel and piano tones

This study evaluated the reliability of pitch judgments as a basic step toward increasing interrater and intrarater reliability of multidimensional perceptual judgments of the speaking voice. Forty-five undergraduate university students studying speech/language pathology made piano-to-piano tone pitch matches and vowel-to-piano pitch matches using a computer software program. The mean percentage correct of piano-to-piano tone matches was 91.3% and of vowel-to-piano matches was 75.6%. Subjects who scored 100% correct were significantly faster at the pitch matching task. Further research of perceptual judgments of pitch and its contribution to multidimensional rating tasks is warranted.     

Three-dimensional modelling of human cytochrome P450 1A2 and its interaction with caffeine and MeIQ

The three-dimensional modelling of proteins is a useful tool to fill the gap between the number of sequenced proteins and the number of experimentally known 3D structures. However, when the degree of homology between the protein and the available 3D templates is low, model building becomes a difficult task and the reliability of the results depends critically on the correctness of the sequence alignment. For this reason, we have undertaken the modelling of human cytochrome P450 1A2 starting by a careful analysis of several sequence alignment strategies (multiple sequence alignments and the TOPITS threading technique). The best results were obtained using TOPITS followed by a manual refinement to avoid unlikely gaps. Because TOPITS uses secondary structure predictions, several methods that are available for this purpose (Levin, Gibrat, DPM, NnPredict, PHD, SOPM and NNSP) have also been evaluated on cytochromes P450 with known 3D structures. More reliable predictions on -helices have been obtained with PHD, which is the method implemented in TOPITS. Thus, a 3D model for human cytochrome P450 1A2 has been built using the known crystal coordinates of P450 BM3 as the template. The model was refined using molecular mechanics computations. The model obtained shows a consistent location of the substrate recognition segments previously postulated for the CYP2 family members. The interaction of caffeine and a carcinogenic aromatic amine (MeIQ), which are characteristic P450 1A2 substrates, has been investigated. The substrates were solvated taking into account their molecular electrostatic potential distributions. The docking of the solvated substrates in the active site of the model was explored with the AUTODOCK programme, followed by molecular mechanics optimisation of the most interesting complexes. Stable complexes were obtained that could explain the oxidation of the considered substrates by cytochrome P450 1A2 and could offer an insight into the role played by water molecules.     

An Overview of Social Participation in Older Adults: Concepts and Assessments

In older adults, social participation is an important component of rehabilitation and health promotion. Several studies have attempted to describe the definition and concepts of social participation, and there were many outcomes to measure social participation. This overview provides information about representative social participation and related concepts that have been defined in the literature. A standardized definition of social participation has not been developed; commonly, recognition for social participation was proposed as focused on involvement in social activities that provide interaction with others in a society or community. Many instruments assess the various aspects of social participation. Because of operational definition and diversity in social participation, performance in social participation was adopted as an aspect of assessment. Further discussions are needed to clarify the definition of social participation and evaluate the instruments used to assess social participation for it to be useful for rehabilitation and health promotion. In doing so, determining and developing assessment and intervention based on the purpose or perspective of social participation in older adults with and without disabilities is important.