Attractors of hypertrophic cardiomyopathy using maximal cliques and attract methods

BackgroundOur study was designed to identify the differential attractor modules related with hypertrophic cardiomyopathy (HCM) by integrating clustering-based on maximal cliques algorithm and Attract method.MethodsWe firstly recruited the HCM-related microarray data from ArrayExpress database. Next, protein–protein interaction (PPI) networks of normal and HCM were constructed and re-weighted using spearman correlation coefficient (SCC). Then, maximal cliques were found from the PPI networks through the clustering-based on maximal cliques approach. Afterwards, highly overlapped cliques were eliminated or merged according to the interconnectivity, and then modules were obtained. Subsequently, we used Attract method to identify differential attractor modules, following by the pathway enrichment analyses for genes in differential attractor modules.ResultsAfter removing the cliques with nodes less than or equal to 4, 926 and 1118 maximal cliques in normal and HCM PPI networks were obtained for module analysis. Then, we obtained 32 and 55 modules from the PPI networks of normal and HCM, respectively. By comparing with normal condition, there were 5 module pairs with the same or similar gene composition. Significantly, based on attract method, we found that these 5 modules were differential attractors. Pathway enrichment analyses indicated that proteasome, ribosome and oxidative phosphorylation were the significant pathways.ConclusionsProteasome, ribosome and oxidative phosphorylation might play pathophysiological roles in HCM.     

深空探测用超导滤波器及滤波放大组件

研制了针对深空探测的超导滤波器和超导滤波放大组件,该超导滤波器在无需后期调谐的情况下,回波损耗大于25.16dB,驻波比小于1.12,插入损耗约0.04dB,阻带抑制达到了115dB以上;超导滤波放大组件的增益为30dB±0.2dB,回波损耗约为20dB;而组件的噪声温度仅为8K~9K。     

Prime orientable graphs

A graph G is prime orientable if it is possible to orient its edges in such a way that the resulting oriented graph is prime, i.e., indecomposable under modular decomposition. We characterize prime orientable graphs.     

On functors between categories of modules over trusses

Categorical aspects of the theory of modules over trusses are studied. Tensor product of modules over trusses is defined and its existence established. In particular, it is shown that bimodules over trusses form a monoidal category. Truss versions of the Eilenberg-Watts theorem and Morita equivalence are formulated. Projective and small-projective modules over trusses are defined and their properties studied.     

Area radiation monitoring on ISS Increments 17 to 22 using PADLES in the Japanese Experiment Module Kibo

The measurement of radiation environmental parameters in space is essential to support radiation risk assessments for astronauts and establish a benchmark for space radiation models for present and future human space activities. The Japan Aerospace Exploration Agency (JAXA) is performing a continuous area radiation monitoring experiment using the “PAssive Dosimeters for Lifescience Experiments in Space” (PADLES) system inside the Japanese Experiment Module Kibo on board the International Space Station (ISS). The PADLES dosimeter consists of thermoluminescent dosimeters (TLDs) and CR-39 plastic nuclear track detectors (PNTDs). JAXA has run the Area PADLES experiment since the Kibo module was attached to the ISS in June 2008, using 17 dosimeters in fixed locations on the Pressurized Module (PM) and the Experiment Logistics Module-Pressurized Section (ELM-PS) of Kibo, which are replaced every 6 months or every Increment, respectively. For three monitoring periods, known as Area PADLES experiment series #1 to #3, of 301, 180, and 232 days in June 2008 to April 2010 over ISS Increments 17 to 22, the average absorbed dose (dose equivalent) rates of 12 positions in the PM of Kibo were 319 ± 30 μGy/day (618 ± 102 μSv/day), 276 ± 30 μGy/day (608 ± 94 μSv/day), and 293 ± 33 μGy/day (588 ± 84 μSv/day), respectively. The radiation measurement in the ELM-PS was conducted in only Area PADLES experiment series #3 from August 2009 to April 2010 (232 days) over ISS Increments 21 to 22, the average absorbed dose (dose equivalent) rates of 5 positions was 297 ± 28 μGy/day (661 ± 65 μSv/day). The directional dependence of the radiation field was also investigated by installing PADLES dosimeters located in the zenith of ELM-PS of Kibo.     

多元低温混合工质相平衡计算模块的开发

微型J-T制冷机是当前低温领域的研究热点之一,采用混合工质可以大幅度提高其热效率。而对多元混合物相平衡计算一直是人们努力研究的内容之一,本文在理论研究的基础上开发了一套完整的计算程序,可用来计算多元混合物的汽-液(LV)、汽-液-液(LLV)、汽-液-液-固(LLVS)相平衡。     

Chain Conditions for Skew Polynomial Modules

§１．ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｒｏｕｇｈｏｕｔｔｈｉｓｐａｐｅｒＲｉｓａｎａｓｓｏｃｉａｔｉｖｅｒｉｎｇｂｕｔｎｏｔｎｅｃｅｓｓａｒｉｌｙｈａｓａｕｎｉｔｙ，ｈｉｓａｎｅｎｄｏｍｏｒｐｈｉｓｍｏｆａｌｅｆｔＲ－ｍｏｄｕｌｅＭ，ａｎｄｗｅｆｒｅｅｌ...     

The Meta-Grothendieck Group of a Ring

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