基于旋转椭球体的等轴状场源体重力异常场模型构建方法

在中心埋藏浅、测量精度高的场合,采用球体作为有限大小、近于等轴状的场源体的模型进行重力异常正演会造成较大误差。提出一种基于旋转椭球体的等轴状场源体重力异常模型。通过改变长、短轴长度以匹配场源体形态,降低正演误差。在已有绕短轴旋转型旋转椭球体的引力位的基础上,推导旋转椭球体完整的重力异常基本表达式。将结果与球体重力异常比较,分析其间的特征差异,验证了结果的正确性。     

万有引力场与库仑场形式上相似性的研究

就均匀薄球壳和均匀带电薄球壳、均匀球体和均匀带电球体的内部以及外部,从场力、场和势三个方面,对它们的相似性作出分析与比较.     

聚N-异丙基丙烯酰胺水溶液在线团-球体转变过程中的溶剂化-去溶剂化效应

聚 N-异丙基丙烯酰胺 (PNIPAM)由于每一重复结构单元上同时存在亲水和疏水基团 ,它的水溶液性质具有异常的特性 ,当溶液的温度从常温逐渐升高到 32℃左右时 ,高分子链的形态尺寸发生突变 ,即所谓线团 -球体转变 .由于 PNIPAM的这种转变过程在理论和实际上的重要性 ,它已成为近年来高分子科学研究中的一个热点[1～ 8] .前人对线团 -球体转变的理论研究都局限在高分子链的形态尺寸变化的描述上 [9～ 18] .新近的实验研究结果证明 ,从线团转变过来的球体里还含有数量不少的溶剂[19,2 0 ] .溶剂的存在与高分子链在溶液中的溶剂化作用有关 …     

球面各向同性球体内的动态热应力集中

利用有限克尔变换得到了求面各向同笥球体的热冲击作用下的动态热应力解析表达式。从表达式中,可以看出球中向同性球体的动态热应力集中现象明显不同于各向同性球体。另外,所描述的动态热应力集中现象与文献「１,３」也有一定的区别。     

Effect of Excipients on Stability and Structure of rhCuZn-SOD Encapsulated in PLGA Microspheres

When a protein is encapsulated into poly (DL-lactide-co-glycolide)(PLGA) microspheres by means of thedouble-emulsion method, the harsh microspheres formation process including ultrasonifieation, exposure toan organic solvent and a polymer may cause the denaturation of the protein. In this study, we investigatedthe enzymatic activity change and the effect of the excipients on the stability of recombinant human Cu ,Zn-su-peroxide dismutase (rhCu, Zn-SOD) during the emulsification. The specific activity recovery was found to beconcentration dependent and the excipients involved such as PEG 600 and Tween 20. and trehalose wereshown to increase the stability of rhCu, Zn-SOD. The protein structural integrity within the microsphereswas analyzed by FTIR. The structure of rhCu, Zn-SOD within PLGA microspheres containing trehalose wasfound to be similar to that of the native solid state, whereas the protein encapsulated during the preparationin the absence of any excipient changed due to the possible hydrophobic interaction with the polymer. The re-sults suggest that a rational stability strategy for protein to be encapsulated into microspheres should aim atdifferent processes.     

Preparation,Characterization,and in vitro Release of Biodegradable Erythromycin-gelatin Microspheres

Blank and erythromycin-loaded gelatin microspheres were successfully fabricated via emulsion chemical- crosslinking technique. The surface morphology of the microspheres was characterized by scanning electron microscope（SEM） and optical microscope. The results show that the microspheres were spherical and smooth. The particle average size of erythromycin-loaded microspheres was found to be 20.6 μm, with a high purity of more than 90% and with a good dispersibility. The microspheres could be obtained in a high yield. Erythromycin released from the microspheres was monitored in buffer and artificial body fluid at 37 ℃. Average drug content was 27.2%, and erythromycin-loaded gelatin microspheres showed good release profiles with a nearly constant release during 4-8 h in artificial body fluid in vitro degradation studies. These gelatin microspheres are useful for studying and developing various drug-delivery systems.     

聚N-异丙基丙烯酰胺在十二烷基硫酸钠水溶液中的线团球体转变

高分子链在溶液中,当溶剂由良变劣时,将发生线团-球体转变,而同时由于链间聚集造成的相分离,使得很难真正观察到热力学意义上稳定的高分子单链紧缩球体。表面活性剂的加入有助于阻止高分子链间发生聚集,在不同的外部条件下,表面活性剂同高分子链将形成形态迥异且又复杂有趣的复合结构。本文主要讨论了聚N-异丙基丙烯酰胺在十二烷基硫酸钠水溶液体系中的线团-球体转变行为,以及聚N-异丙基丙烯酰胺与十二烷基硫酸钠分子间的相互作用及结构模型。     

Integral Equations for the Spin-Weighted Spheroidal Wave Functions

We present new integral equations for the spin-weighted spheroidal wave functions which in turn should lead to global uniform estimates and should help in particular in the study of their dependence on the parameters. For the prolate spheroidal wavefunction with m=0, there exists the integral equation whose kernel is （sin x）/x, and the sinc function kernel （sin x）/x is of great mathematical significance. We also extend the similar sinc function kernel （sin x）/x to the case m≠0 and s≠0, which interestingly turn out as some kind of Hankel transformations.