靶向VEGFR受体抑制剂齐墩果酸衍生物的合成及初步抗肿瘤活性研究

以天然产物齐墩果酸为母体,设计合成齐墩果酸衍生物,采用计算机辅助药物设计,对C-3、C-28位结构改造,设计合成12个未见文献报道的靶向VEGFR受体抑制剂; 采用噻唑蓝(MTT)法,用人肝癌细胞(HepG2)和乳腺癌细胞(MCF-7)对其进行初步体外抗肿瘤活性筛选;其结构经1H-NMR、13C-NMR谱确证。活性测试得出化合物I7、II1与阳性对照药相比有较强抑制作用,其抗肿瘤活性高于母体OA,分子对接结果显示I7和II1 与 VEGFR 受体具有较好的结合能力,值得进一步研究。     

HI-13串列加速器辐射防护联锁系统改造

新建HI-13串列加速器辐射防护联锁系统采用PLC自动化控制,增加与优化了原系统的联锁控制逻辑,在充分保证人员辐射安全的同时,使系统状态显示更直观,操作更方便.     

光栅莫尔条纹在机床数控改造中的应用研究

从机床数控改造的实际出发,针对我国目前国产机床加工精度普遍不高,数控化程度较低等问题,提出了一种全新的设计方案,利用光栅作为位置检测元件,形成全闭环控制系统,结果表明既能够大大提高零件的加工精度,又能节省改造成本,为机床数控改造提供了参考。     

低能强流离子束输运实验台控制系统的研制

介绍了一种基于Siemens S7-300 PLC的计算机控制系统,用于对北京大学重离子物理研究所低能强流离子柬实验台设备的自动控制和束流监测.该系统通过PROFIBUS-DP过程现场总线完成主站和从站的数据交换和分布控制,上位机采用Siemens WinCC软件集中监控,实现可视化过程控制、数据记录和保存、报警和自动保护、远程控制和数据通信等功能.本文着重阐述在离子束输运装置对控制系统基本要求的基础上,如何选择系统结构并确定系统方案,以及对现有设备的自动化改造、软硬件的合理配置、可视化人机操作界面的设计.     

Corey化学酶的结构改造对催化性能的影响

综述了Corey化学酶的结构改造与催化性能之间关系,为有目的地选择和设计高效实用的手性催化剂用于有机不对称合成提供依据.     

Double-image sharing encryption based on associated fractional Fourier transform and gyrator transform

<正>We present a novel method for realizing double-image encryption algorithm by combining the images in different transform domains.Two original images are encrypted into two interim images by fractional Fourier transform and gyrator transform,respectively.The two encrypted images can be obtained by means of the addition and subtraction of the two interim images.This is defined as a double-image sharing scheme,in which the original images are encrypted into two parts.The original images cannot be recovered only with any one of the two interim images.Numerical simulation experiments demonstrate the validity of the algorithm.     

ORG500W/4.5K制冷机的改造流程设计计算及分析

介绍了带LN2预冷的二级膨胀循环的流程计算方法,并提出了优化计算的思路和计算机程序实现的方法;最后就换热器热端温差对制冷机效率的影响进行了讨论     

Short range order transformation and magnetostriction of Fes3Ga17 ribbons

The relationship between magnetostriction and structure of melt-spun Fes3Ga17 ribbons are investigated by XRD and M5ssbauer spectrum technique （MS）. As the heat-treatment temperature increases from 650℃ to 800℃, the magnetostriction coefficient of Fes3Ga17 ribbon first increases and then decreases. The largest magnetostriction coeiffcient （-578.4 ppm） is achieved in those specimens quenched at 750oc. According to the XRD and MSssbauer spectrum anal- ysis, a small quantity of DO3 phase is precipitated in Fe83Ga17 ribbons when quenched from 650℃ and the DO3 phase is gradually transformed into B2-1ike phase if quenched at higher temperature. However, both DO3 and B2-1ike phases disappear when the temperature increases up to 800℃. From this point of view, B2-1ike phase might be beneficial to the enhancement of magnetostrictive properties of melt-spun ribbons.     

生物力学与基因-献给周培源教授诞辰100周年

生物界包罗万象,其中有力的作用,所以有生物力学.自Galileo,Harvey, Boreli, Hooke, Euler,Young等创始以来,生物力学阐明了鸟飞鱼游,人体运动,血液循环,人工脏器等,对人世社会,有所贡献.生物力学的基础是质点力学,传统地用连续体力学的概念来简化.但近年做生物组织在应力的作用下改造的问题,引起了必须更改传统连续体力学的几个公理的问题.我们将仔细讨论这些公理,然后指出新公理存在的理由,是由于基因在细胞里的日常工作.基因不单主宰遗传,变异;并且忙着控制日常生活.不过,现在仅见其端倪.详细的情形,要等将来来阐发了.      

Generation of millimeter-wave sub-carrier optical pulse by using cascaded all-pass cavities

A novel scheme is proposed to transform an ultra-short optical pulse to a millimeter-wave frequencymodulated pulse by using the cascaded all-pass cavities （APCs）. The envelope waveform of the generated pulse train is calculated, showing effective improvement by APC cascading. The extinction ratio is analyzed with different input pulses, different cavity reflectivities, and different cascading numbers. It is shown that the cascading does not introduce much effect on the extinction ratio. Two designs by using Gires-Tournois cavity and waveguide ring resonators are proposed to realize the cascaded APC.