Comparison of tumor histology to dynamic contrast enhanced magnetic resonance imaging-based physiological estimates

Purpose

The purpose of this study was to compare histologically determined cellularity and extracellular space to dynamic contrast-enhanced magnetic resonance imaging (DCE MRI)-based maps of a two-compartment model's parameters describing tumor contrast agent extravasation, specifically tumor extravascular extracellular space (EES) volume fraction (v_e), tumor plasma volume fraction (v_p) and volume-normalized contrast agent transfer rate between tumor plasma and interstitium (K_TRANS/V_T).

Materials and Methods

Obtained v_e, v_p and K_TRANS/V_T maps were estimated from gadolinium diethylenetriamine penta-acetic acid DCE T₁-weighted gradient-echo images at resolutions of 469, 938 and 2500 μm. These parameter maps were compared at each resolution to histologically determined tumor type, and the high-resolution 469-μm maps were compared with automated cell counting using Otsu's method and a color-thresholding method for estimated intracellular (V_{intracellular}) and extracellular (V_{extracellular}) space fractions.

Results

The top five K_TRANS/V_T values obtained from each tumor at 469 and 938 μm resolutions are significantly different from those obtained at 2500 μm (P<.0001) and from one another (P=.0014). Using these top five K_TRANS/V_T values and the corresponding tumor EES volume fractions v_e, we can statistically differentiate invasive ductal carcinomas from noninvasive papillary carcinomas for the 469- and 938-μm resolutions (P=.0017 and P=.0047, respectively), but not for the 2500-μm resolution (P=.9008). The color-thresholding method demonstrated that v_e measured by DCE MRI is statistically similar to histologically determined EES. The V_{extracellular} obtained from the color-thresholding method was statistically similar to the v_e measured with DCE MRI for the top 10 K_TRANS/V_T values (P>.05). DCE MRI-based K_TRANS/V_T estimates are not statistically correlated with histologically determined cellularity.

Conclusion

DCE MRI estimates of tumor physiology are a limited representation of tumor histological features. Extracellular spaces measured by both DCE MRI and microscopic analysis are statistically similar. Tumor typing by DCE MRI is spatial resolution dependent, as lower resolutions average out contributions to voxel-based estimates of K_TRANS/V_T. Thus, an appropriate resolution window is essential for DCE MRI tumor diagnosis. Within this resolution window, the top K_TRANS/V_T values with corresponding v_e are diagnostic for the tumor types analyzed in this study.     

图形处理器并行计算用于离子发动机粒子模拟

 为了研究离子发动机羽流对航天器的影响,采用质点网格-蒙特卡罗碰撞方法对离子发动机羽流中的交换电荷离子进行了模拟。利用计算设备统一架构技术,开发出一套基于图形处理器的并行粒子模拟程序。随机数生成采用并行MT19937伪随机数生成器算法,电场方程使用完全近似存储格式的代数多重网格法求解。r-z轴对称坐标系中,在z=0 m处获得的电流密度均值为4.5×10^-5 A/m²,图形处理器所得结果与中央处理器模拟结果吻合。在16核心的NVIDIA GeForce 9400 GT图形显示卡上,取得相对于Intel Core 2 E6300中央处理器4.5~10.0倍的加速比。     

风机盘管机组换热器的分析与改进

分析了影响风机盘管换热器传热性能的主要因素并提出相应的解决措施.采用理论分析与计算的方法,从提高传热效率出发对热交换器进行了改进.对于企业降低生产成本、提升产品性能和提高市场竞争力具有重要意义.     

An experimental study on effects of solid concentration and ζ-potential on pseudoplastic flow of suspensions

The pseudoplastic flow of suspensions, alumina or styrene-acrylamide copolymer particles in water or an aqueous solution of glycerin has been studied by the step-shear-rate method. The relation between the shear rate,D, and the shear stress,, in the step-shear-rate measurements, where the state of dispersion was considered to be constant, was expressed as = AD ^1/2 +CD. The effective solid volume fraction,ø _F, andA were dependent on the shear rate and expressed byø _F =aD ^b andA = D . Combining the above relations, the steady flow curve was expressed by = D ^{1/2 +} + ₀ (1 – a D ^b/0.74)^–1.85 D, where ₀ is the viscosity of the medium.With an increase in solid volume fraction and a decreases in the absolute value of the-potential, the flow behavior of the suspensions changed from Newtonian ( = = b = 0), slightly pseudoplastic ( = b = 0), pseudoplastic ( = 0) to a Bingham-like behavior.The change in viscosity of the medium had an effect on the change in the effective volume fraction.     

Brownian motion of nonlinear oscillators: The projection operator method and its application to a double-well-potential oscillator

A projection operator method is presented, which provides the most efficient way for calculating the stationary behavior of nonlinear Brownian motion. A continued-fraction expansion of the Fourier-Laplace transform of the displacement correlation function or the spectral density is used. This method utilizes a successive optimization procedure on the nonlinear terms and includes the method of statistical linearization as the lowest order approximation. A systematic way to calculate the continued fraction numerically up to sufficient order for convergence is developed, which enables us to obtain the spectral density of a system previously uncomputable.Numerical computations of the spectral density of a nonlinear oscillator with a double-well potential are presented and compared with the results obtained by statistical linearization.This work was supported in part by the National Science Foundation under Grant CHE 75-20624.     

Quantum Fourier Transform-Based Arithmetic Logic Unit on a Quantum Processor

This study proposes and construct a primitive quantum arithmetic logic unit (qALU) based on the quantum Fourier transform (QFT). The qALU is capable of performing arithmetic ADD (addition) and logic NAND gate operations. It designs a scalable quantum circuit and presents the circuits for driving ADD and NAND operations on two-input and four-input quantum channels, respectively. By comparing the required number of quantum gates for serial and parallel architectures in executing arithmetic addition, it evaluates the performance. It also execute the proposed quantum Fourier transform-based qALU design on real quantum processor hardware provided by IBM. The results demonstrate that the proposed circuit can perform arithmetic and logic operations with a high success rate. Furthermore, it discusses in detail the potential implementations of the qALU circuit in the field of computer science, highlighting the possibility of constructing a soft-core processor on a quantum processing unit.     

一种局部相含率测量方法

在局部电导探针和单丝电容探针的基础上,提出一种新型局部电容探针,用于测量两相流的局部相含率。静态研究表明,局部电容探针能够测量空气水两相流的局部相含率,测量结果不受导电相电导率变化的影响。从工业蒸馏水变化到饱和食盐水(NaCl的质量分数0～5%),局部电容探针输出结果没有明显变化。电极距离在0～30 mm的范围内变化,测量结果变化小于1%。动态实验表明,局部电容探针测量的两相流的局部相含率,能够很好反映流动过程(以弹状流为例),和实验观察结果完全一致。只需要设置简单的阈值大小,就可以得到相含率的大小。     

Negative refraction and imaging of acoustic waves in a two-dimensional square chiral lattice structure

The negative refraction behavior and imaging effect for acoustic waves in a kind of two-dimensional square chiral lattice structure are studied in this paper. The unit cell of the proposed structure consists of four zigzag arms connected through a thin circular ring at the central part. The relation of the symmetry of the unit cell and the negative refraction phenomenon is investigated. Using the finite element method, we calculate the band structures and the equi-frequency surfaces of the system, and confirm the frequency range where the negative refraction is present. Due to the rotational symmetry of the unit cell, a phase difference is induced to the waves propagating from a point source through the structure to the other side. The phase difference is related to the width of the structure and the frequency of the source, so we can get a tunable deviated imaging. This kind of phenomenon is also demonstrated by the numerical simulation of two Gaussian beams that are symmetrical about the interface normal with the same incident angle, and the different negative refractive indexes are presented. Based on this special performance, a double-functional mirror-symmetrical slab is proposed for realizing acoustic focusing and beam separation.     

Ermittlung der Korrektionsfaktoren für den Streustrahlungszusatz und die Blendendurchstrahlung bei der Absolutdarstellung der Expositionseinheit im Energiebereich von 0,6 bis 2,0 MeV

In der Arbeit wird die Bestimmung der Korrektionsfaktoren für den Strnustrahlungzusatz (K_st) und für die Blendendurch strahlung (K_b) für Normalmeβeinrichtungen zur Darstellung der Einheit der Exposition behandelt. Die für K_st abgeleitete Formel kann auf Normalkammern mit beliebigen geometrischen Abmessungen übertragen werden. Die Beziehung für K_B gilt für eine Meβblende mit zylindrischer Bohrung. Für die Faktoren K_st und K_B werden Werte angedgenben, die sich auf die Normalmeβeinrichtung des ASMW beziehen.     

Modelling effects of subgrid-scale mixture fraction variance in LES of a piloted diffusion flame

A posteriori analysis of the statistics of two large-eddy simulation (LES) solutions describing a piloted methane–air (Sandia D) flame is performed on a series of grids with progressively increased resolution reaching about 10.5 million cells. Chemical compositions, density and temperature fields are modelled with a steady flamelet approach and parametrised by the mixture fraction. The difference between the LES solutions arises from a different numerical treatment of the subgrid scale (SGS) mixture fraction variance – an important quantity of interest in non-premixed combustion modelling. In the first case (model I), the variance transport equation is solved directly, while in the second (model II), an equation for the square of the mixture fraction is solved, and the variance is computed from its definition. The comparison of the LES solutions is based on the convergence properties of their statistics with respect to the turbulence resolution length scale. The dependence of the LES statistics is analysed for velocity and the mixture fraction fields, and tested for convergence. For the most part, the statistics converge for the finest grids, but the variance of the mixture fraction shows some residual grid dependence in the high-gradient regions of the jet near field. The SGS variance given by model I exhibits realisability everywhere, whereas in regions of the flame model II is non-realisable, predicting negative variances. Furthermore, the LES statistics of model I exhibit superior convergence behaviour.