空腹式刚架拱桥梁拱节点三维光弹性试验研究

福州市尤溪洲闽江大桥是国内首座在拱肋（圈）上不设立柱和斜撑的空腹式刚架拱桥．作为空腹式刚架拱桥受力关键部位——梁与拱的连接部位，受力及构造复杂．通过三维光弹性试验，研究该梁、拱结合部的内力传递、应力集中、局部应力分布规律，为空腹式刚架拱桥节点设计、施工提供依据．     

有限尺寸多钉连接件钉传载荷计算的解析方法

提供一种确定多钉连接件中钉传载荷的解析方法，这个方法将被连接件看作弹性体，以经典结构力学以及弹性理论平面问题复变函数解法为基础，建立了求解钉传载荷的线性代数方程组并给出了若干算例。这个方法不仅具有合理的力学模型，而且具有计算的简捷性与适用的广泛性。     

Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma

Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD) characterized by non-eosinophilic inflammation. Acetyl salicylic acid (ASA) is one of the most widely used medications worldwide, but up to 20% of patients with asthma experience aggravated respiratory symptoms after taking ASA. Here we evaluated the adverse effect of ASA on the therapeutic effect of theophylline in mice with non-eosinophilic asthma. A non-eosinophilic asthma mouse model was induced by airway sensitization with lipopolysaccharide-containing allergen and then challenged with allergen alone. Therapeutic intervention was performed during allergen challenge. Theophylline inhibited lung inflammation partly induced by T_h1 immune response. ASA attenuated the beneficial effects of theophylline. However, co-administration of the ASA metabolite salicylic acid (SA) showed no attenuating effect on theophylline treatment. The therapeutic effect of theophylline was associated with increase in cAMP levels, which was blocked by co-treatment of theophylline and ASA. ASA co-treatment also attenuated the anti-inflammatory effects of a specific phosphodiesterase 4 inhibitor. These results demonstrate that ASA reverses anti-inflammatory effects of theophylline, and that ASA exerts its adverse effects through the inhibition of cAMP production. Our data suggest that ASA reverses lung inflammation in patients taking theophylline, although clinical evidence will be needed.     

The toxicity of Cu~(2+) to Microcystis aeruginosa using dielectric spectroscopy

Dielectric spectroscopy(DS) was utilized to investigate the toxicity of the Cu2+ solution to Microcystis aeruginosa.It was found that 0.04 mM Cu2+ had no effect on dielectric increment,whereas the Cu2+ concentrations above 0.1 mM decreased the value of Δε/Δε intact.The toxic effect of Cu2+ on M.aeruginosa cells was time-dependent and concentration-dependent.There was a threshold concentration between 0.04 mM and 0.1 mM,which affected the cell membrane,suggesting that Cu2+ at the concentrations higher than 0...     

Specific molecular and cellular events induced by irradiated X‐ray photoactivatable drugs raise the problem of co‐toxicities: particular consequences for anti‐cancer synchrotron therapy

Synchrotrons are capable of producing intense low‐energy X‐rays that enable the photoactivation of high‐Z elements. Photoactivation therapy (PAT) consists of loading tumors with photoactivatable drugs and thereafter irradiating them at an energy, generally close to the K‐edge of the element, that enhances the photoelectric effect. To date, three major photoactivatable elements are used in PAT: platinum (cisplatin and carboplatin), iodine (iodinated contrast agents and iododeoxyuridine) and gadolinium (motexafin gadolinium). However, the molecular and cellular events specific to PAT and the radiobiological properties of these photoactivatable drugs are still misknown. Here, it is examined how standard and synchrotron X‐rays combined with photoactivatable drugs impact on the cellular response of human endothelial cells. These findings suggest that the radiolysis products of the photoactivatable drugs may participate in the synergetic effects of PAT by increasing the severity of radiation‐induced DNA double‐strand breaks. Interestingly, subpopulation of highly damaged cells was found to be a cellular pattern specific to PAT. The data show that the efficiency of emerging anti‐cancer modalities involving synchrotron photoactivation strongly depends on the choice of photoactivatable drugs, and important series of experiments are required to secure their clinical transfer before applying to humans.     

THE EXTINCTION OF A NON-AUTONOMOUS ALLELOPATHIC PHYTOPLANKTON MODEL WITH FEEDBACK CONTROLS

A non-autonomous allelopathic phytoplankton model with feedback controls is considered in this paper. By constructing some suitable Lyapunov type extinction functions, some sufficient conditions for the extinction of the system are obtained. For the autonomous case, by constructing a suitable Lyapunov function, we show that one species is extinct and the rest species is globally attractive. Our results supplement some known results.     

动态联合库存的决策模型及算法

考虑生产商、销售商联合库存的动态优化问题,建立的随机需求下生产-销售运作系统的排队模型,得到了系统的稳态概率分布和队长分布.以成本最小化为目标,模型算法找到了最优的运作策略和机器使用数量.数值模拟的结果表明,依赖于指定机器数量的动态调整策略明显优于静态系统.