乳化剂OP存在下桑色素与Al（Ⅲ）Mo（Ⅵ）显色反应的研究及应用

研究了非离子型表面活性剂ＯＰ存在下，桑色素与Ａｌ（Ⅲ）Ｍｏ（Ⅵ）显色反应的适宜条件。在０．１２ｍｏｌ．Ｌ＾－１乙酸介质中，桑色素与Ａｌ（Ⅲ）的配合物最大吸收波长为４２０ｎｍ，表观摩尔吸光系数为１．３７＊１０＾５，Ａｌ（Ⅲ）浓度在０－２．０μｇ／１０ｍｌ范围内呈良好的线性关系。     

The use of POSS as synergist in intumescent recycled poly(ethylene terephthalate)

Fire retarded poly(ethylene terephthalate) (PET) has been obtained by the incorporation of octamethyl polyhedral oligomeric silsesquioxane (OMPOSS) and Exolit OP950, a phosphinate-based compound, in recycled PET. The presence of Exolit OP950 only leads to intumescence explaining the improvement of the flame retardancy. The addition of OMPOSS leads to a synergistic effect considerably increasing the fire retarding performances of the polymer in terms of cone calorimetry and limiting oxygen index even if a small thermal stabilisation as well as a very poor dispersion of OMPOSS and OP950 into the matrix has been observed.     

Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2-a]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action

The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the final effect of analgesia. Classical agonists of this receptor, such as morphine, are the main targets in the treatment of both acute and chronic pain. However, the dangerous side effects, such as respiratory depression or addiction, significantly limit their widespread use. The allosteric centers of the receptors exhibit large structural diversity within particular types and even subtypes. Currently, a considerable interest is aroused by the modulation of μ-opioid receptors. The application of such a technique may result in a reduction in the dose or even discontinuation of classical opiates, thus eliminating the side effects typical of this class of drugs. Our aim is to obtain a series of 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazo[1,2-a]imidazole derivatives and provide more information about their activity and selectivity on OP3 (MOP, human mu opioid receptor). The study was based on an observation that some carbonyl derivatives of 1-aryl-2-aminoimidazoline cooperate strongly with morphine or DAMGO in sub-threshold doses, producing similar results to those of normal active doses. To elucidate the possible mechanism of such enhancement, we performed a few in vitro functional tests (involving cAMP and β-arrestin recruitment) and a radioligand binding assay on CHO-K1 cells with the expression of the OP3 receptor. One of the compounds had no orthosteric affinity or intrinsic activity, but inhibited the efficiency of DAMGO. These results allow to conclude that this compound is a negative allosteric modulator (NAM) of the human μ-opioid receptor.