2'-(1-萘亚甲基)-2-羟基苯甲酰腙的合成、晶体结构及抑菌活性

某些席夫碱化合物具有抗肿瘤、抗菌等生物活性,在生化反应中起到转氨基作用,碳氨双键是该类化合物具有抗菌活性的效应基团。而含-CONHN=CH-基团的酰腙类化合物具有特殊的生物活性和强配位能力,在农药、医药和分析试剂等方面一直是人们广泛研究的对象,某些该类化合物在治疗一些疾病和抑菌方面已有广泛的应用。为了进一步探索高效抗菌药物,本研究组在从事席夫碱及腙类化合物的合成、生物活性的测定等工作中合成了标题化合物;并测定了标题化合物对枯草芽孢杆菌、肺炎克氏菌、铜绿脓杆菌、大肠杆菌和金黄色葡萄球菌的抑菌活性。     

片螺素中间体——2,4,5-三甲氧基-α-卤代苯乙酮的合成研究

片螺素[1](Lamel larin)及其类似生物碱是近年来自海洋生物中分离得到的一种海洋活性物质,迄今为止发现有39种[1][2]。所有的片螺素都具有一定的生物活性[3]。但由于海洋生物中片螺素具有含量低,分离困难等特点,因而其合成研究是十分有意义的。本课题组在国家自然基金资助下,设     

One-dimensional Zigzag Chain Composed of HgI2 Unit and 2,5-Bis（4-pyridyl）- 1,3,4-thiadiazole： [HgI2（C12H8N4S）]

1 INTRODUCTION Much interest has been focused on the design and syntheses of supramolecular coordination polymers with novel topologies and structural motifs because of their encouraging potential applications in the fields of nonlinear optics, catalysis and separation, magnetism and molecular recognition[1, 2]. In princi- ple, control over the type and topology of the coor- dination polymers can be achieved by careful choice of ligand, metal coordination geometry preference, inorganic cou…     

Synthesis and Crystal Structure of 4,4′-(4-(1-Naphthyl)-4-phenyl- 1,3-butadienylidene)-bis[N,N-diethylbenzenamine]

The title compound (C40H42N2) has been synthesized by the reaction of 1-(1-naphthyl)-1-phenyl-3-chloropropylene and bis(4-(diethylamino) phenyl)methanone, and characterized by IR, 1H NMR, MS and X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/c with a = 17.047(3), b = 10.807(2), c = 1&494(4) (A), β = 105.727(4)°, V=3279.4(11) A3, Mr = 550.76, Z = 4, Dc = 1.115 g/cm3, μ(MoKα) = 0.085 mm-1, F(000) = 1184, the final R = 0.0625 and wR = 0.1384 for 2276 observed reflections (I ＞ 2σ(Ⅰ)). X-ray analysis reveals that the butadiene fragment adopts a planar cisiod conformation and makes a dihedral angel of 69.4(2)° with the naphthalene ring.     

1,5-Dimethy-4-[(3-nitro-benzylidene)-amino]-2-pheyl-1,2-dihydro-pyrazol-3-one

1INTRODUCTION Antipyrine(2,3-dimethyl-1-phenyl-5-pyrazolone)and its derivatives exhibit a wide range of biological activities and applications[1~3].Antipyrine shows mi-nimal protein binding and is rapidly and completely absorbed from the gastrointestinal tract and exten-sively metabolized by the cytochrome P450liver en-zymes[4].Estimates of half-life and systemic cleara-nce of antipyrine have been used for the in vivo asse-ssment of hepatic drug oxidation in different spe-cies[5].Owing to…     

Reactive polymers incorporating silyl enol ether groups. I. synthesis by radical polymerization of 2-(trimethylsiloxy)-butadiene and 2-(tert)-butyldimethylsiloxy butadiene

2-(Trimethylsiloxy)butadiene (TMSBD) and 2-(tert-butyldimethylsiloxy)butadiene (TBMSBD) were copolymerized with styrene (St) and methyl methacrylate (MMA) under free-radical conditions. The obtained polymers were found to contain reactive silyl enol ether groups in a ratio identical to the TMSBD or TBMSBD molar fraction in the copolymer. All investigated samples displayed only 1,4- and 3,4-microstructures. The influence of several experimental factors on the yields, rates of polymerization, microstructures, and copolymer compositions were examined. Monomer reactivity ratios r₁ and r₂ at 60°C were determined from copolymer composition curves at low conversions. The homopolymerization of TBMSBD was also investigated and results were compared with those previously obtained for TMSBD. A slight increase in rates was observed and was rationalized on the basis of the higher viscosity resulting from the structural change in the monomer. Thermal stabilities of the synthesized polymers were investigated by TGA and their glass transition temperatures were determined by DSC. All measurements are compatible with a possible use of TMSBD and TBMSBD copolymers as reactive polymers. © 1996 John Wiley & Sons, Inc.     

Synthesis of 1-O-R-5-deoxy-β-D-ribofuranosides with (CH3)2As and (CH3)2AsO as substituents at the 5-position and a methyl or 2′,3′-dihydroxypropyl group as the aglycone in the 1-position

Six arsenic-containing β-D -ribofuranosides, including the naturally occurring (2′R)-dimethyl[1-O-(2′,3′-dihydroxypropyl)-5-deoxy-β-D -ribofuranos-5-yl]arsine oxide, were prepared in multi-step reactions from D -ribose and tetramethyldiarsine. The synthetic procedure uses the early substitution of the hydroxy group with bromine at C5, subsequent attachment of a chiral three-carbon aglycone at C1, and final delivery of arsenic at C5. The synthesis provides a viable route for the preparation of multigram quantities of the natural product.     

非强占优先权下的M/M/1排队

分析带有两个优先权的非强占M/M/1系统的性能,用补充变量法构造向量马尔可夫过程对此排队系统的状态转移方程进行分析,得到两类顾客在非强占优先权的队长联合分布的母函数,进一步讨论,得出了服务台被两类顾客占有和闲置的概率以及两类信元各自的平均队长.     

高效液相色谱-串联质谱法测定鸡组织中的喹烯酮标示残留物

采用液相色谱-串联质谱（HPLC—MS／MS）法测定鸡组织（肌肉、肝、肾）中喹烯酮标示残留物3-甲基喹噁啉-2-羧酸的含量。组织匀浆样品经碱水解、液液萃取,采用HPLC—MS／MS电喷雾电离（ESI）,正离子模式,多反应监测（MRM）,以喹噁啉-2-羧酸为内标进行定量。检出限为5μg／kg。