Understanding the mechanisms of cancers based on function sub-pathways

Pathway analysis has become a popular technology tool for gaining insight into the underlying biology of differentially expressed genes and proteins. Although many sub-pathways analysis methods have been proposed, the function of these sub-pathways is generally implicit. In this paper, we propose a function sub-pathway analysis (FSPA) method which includes all nodes reaching a specific function node at the downstream of pathways. The perturbation degree of a sub-pathway is defined as the negative of the log p-value of the sub-pathway. The proposed FSPA allows analyzing the differentially expressed genes in a sub-pathway with diseases in explicit function level. Results from six datasets of colorectal cancer, lung cancer and pancreatic cancer show that the proposed FSPA could identify more cancer associated pathways. And more importantly, it could identify which sub-pathways lead to a specific abnormal function, and to what extent it affects the function. Furthermore, the proposed perturbation degree could also analyze the imbalance of some functions involved in some biological process. The results by FSPA are helpful for elucidating the underlying mechanisms of cancers and designing therapeutic strategies.     

Constructing new differentially 4-uniform permutations from the inverse function

Two new families of differentially 4-uniform permutations over ${\mathbb{F}}_{2^{2m}}$ are constructed by modifying the values of the inverse function on some subfield of ${\mathbb{F}}_{2^{2m}}$ and by applying affine transformations on the function. The resulted 4-uniform permutations have high nonlinearity and algebraic degree. A family of differentially 6-uniform permutations with high nonlinearity and algebraic degree is also constructed by making the modification on an affine subspace of ${\mathbb{F}}_{2^{2m}}$.     

Transient natural convection of low-Prandtl-number fluids in a differentially heated cavity

The transient convective motion in a two-dimensional square cavity driven by a temperature gradient is analysed. The cavity is filled with a low-Prandtl-number fluid and the vertical walls are maintained at constant but different temperatures, while the horizontal boundaries are adiabatic. A control volume approach with a staggered grid is employed to formulate the finite difference equations. Numerically accurate solutions are obtained for Prandtl numbers of 0·001, 0·005 and 0·01 and for Grashof numbers up to 1 × 10⁷. It was found that the flow field exhibits periodic oscillation at the critical Grashof numbers, which are dependent on the Prandtl number. As the Prandtl number is decreased, the critical Grashof number and the frequency of oscillation decrease. Prior to the oscillatory flow, steady state solutions with an oscillatory transient period were predicted. In addition to the main circulation, four weak circulations were predicted at the corners of the cavity.     

Horizontal convection: Effect of aspect ratio on Rayleigh number scaling and stability

Horizontal convection in a rectangular enclosure driven by a linear temperature profile along the bottom boundary is investigated numerically using a spectral-element discretization for velocity and temperature fields. A Boussinesq approximation is employed to model buoyancy. The emphasis of this study is on the scaling of mean Nusselt number and boundary layer quantities with aspect ratio and Rayleigh number.     

Weak type inequality for noncommutative differentially subordinated martingales

In the paper we focus on self-adjoint noncommutative martingales. We provide an extension of the notion of differential subordination, which is due to Burkholder in the commutative case. Then we show that there is a noncommutative analogue of the Burkholder method of proving martingale inequalities, which allows us to establish the weak type (1,1) inequality for differentially subordinated martingales. Moreover, a related sharp maximal weak type (1,1) inequality is proved. Research supported by MEN Grant 1 PO3A 012 29.