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研究了大口径非球面光学元件表面轮廓测量过程可视化,并设计、开发了基于双向链接边表的软件系统。提出一种改进的双向链接边表数据结构完成三维模型加载方法,建立数据结构及其相关图形元作为软件的基础层。计算非球面曲面方程获得表面轮廓的数据生成图形场景节点,并自动生成曲面测量轨迹。在非接触检测平台上进行测试,对测量数据进行平滑处理,拟合出测量获得的非球面面形,完成面形精度和表面粗糙度的评价。实验结果表明,该可视化系统技术路线正确高效、稳定性好,为非球面检测数据及其综合分析仿真提供直观的可视化平台。 相似文献
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G-quadruplexes (G4) are the most actively studied non-canonical secondary structures formed by contiguous repeats of guanines in DNA or RNA strands. Small molecule mediated targeting of G-quadruplexes has emerged as an attractive tool for visualization and stabilization of these structures inside the cell. Limited number of DNA and RNA G4-selective assays have been reported for primary ligand screening. A combination of fluorescence spectroscopy, AFM, CD, PAGE, and confocal microscopy have been used to assess a dimeric carbocyanine dye B6,5 for screening G4-binding ligands in vitro and in cellulo. The dye B6,5 interacts with physiologically relevant DNA and RNA G4 structures, resulting in fluorescence enhancement of the molecule as an in vitro readout for G4 selectivity. Interaction of the dye with G4 is accompanied by quadruplex stabilization that extends its use in primary screening of G4 specific ligands. The molecule is cell permeable and enables visualization of quadruplex dominated cellular regions of nucleoli using confocal microscopy. The dye is displaced by quarfloxin in live cells. The dye B6,5 shows remarkable duplex to quadruplex selectivity in vitro along with ligand-like stabilization of DNA G4 structures. Cell permeability and response to RNA G4 structures project the dye with interesting theranostic potential. Our results validate that B6,5 can serve the dual purpose of visualization of DNA and RNA G4 structures and screening of G4 specific ligands, and adds to the limited number of probes with such potential. 相似文献
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Investigations have been performed on convective heat transfer in water flowing through mini-channels using the non intrusive technique of laser interferometry coupled with digital image processing. Optical glass channels, fabricated with metallic heating surfaces, were studied using a Mach-Zehnder interferometer configuration. Fringe patterns captured using a high-sensitivity CCD camera were analyzed digitally based on a calculation method developed for the liquid medium. Results of parametric studies were compared and contrasted with relevant theoretical solutions from the literature. Indication of the onset of turbulence at Reynolds numbers smaller than the conventional transition Reynolds number for large channels has also been noticed in the experimental investigation. 相似文献
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《Journal of computational chemistry》2017,38(29):2538-2552
Chemical research is assisted by the creation of visual representations that map concepts (such as atoms and bonds) to 3D objects. These concepts are rooted in chemical theory that predates routine solution of the Schrödinger equation for systems of interesting size. The method of Quantum Chemical Topology (QCT) provides an alternative, parameter‐free means to understand chemical phenomena directly from quantum mechanical principles. Representation of the topological elements of QCT has lagged behind the best tools available. Here, we describe a general abstraction (and corresponding file format) that permits the definition of mappings between topological objects and their 3D representations. Possible mappings are discussed and a canonical example is suggested, which has been implemented as a Python “Add‐On” named Rhorix for the state‐of‐the‐art 3D modeling program Blender. This allows chemists to use modern drawing tools and artists to access QCT data in a familiar context. A number of examples are discussed. © 2017 The Authors. Journal of Computational Chemistry Published by Wiley Periodicals, Inc. 相似文献
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Crystal L. Pace Kenneth P. Garrard David C. Muddiman 《Journal of mass spectrometry : JMS》2022,57(7):e4872
Untargeted analyses in mass spectrometry imaging produce hundreds of ion images representing spatial distributions of biomolecules in biological tissues. Due to the large diversity of ions detected in untargeted analyses, normalization standards are often difficult to implement to account for pixel-to-pixel variability in imaging studies. Many normalization strategies exist to account for this variability, but they largely do not improve image quality. In this study, we present a new approach for improving image quality and visualization of tissue features by application of sequential paired covariance (SPC). This approach was demonstrated using previously published tissue datasets such as rat brain and human prostate with different biomolecules like metabolites and N-linked glycans. Data transformation by SPC improved ion images resulting in increased smoothing of biological features compared with commonly used normalization approaches. 相似文献
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针对现有运载火箭试验数据管理及可视化系统依赖于第三方功能插件,未实现纯浏览器端三维模型渲染及交互,系统对运行环境依赖性强、部署和维护成本高等问题,设计了基于JavaScript框架ExtJS和WebGL框架three.js的运载火箭试验数据管理及可视化系统。首先基于B/S架构设计了系统总体框架,然后针对二维图形数据传输延迟问题设计了基于Web Worker的数据读取方案,最后针对浏览器端三维模型渲染需求提出了基于VTK模型的转换算法,设计了三维模型渲染及交互方案。试验结果显示,本系统不依赖于运行环境和功能插件,能实现浏览器端二维图形和三维模型渲染及流畅交互,为兼容国产化操作系统、降低部署和维护成本创造了条件。 相似文献