Magnetic properties and electron spin resonance of Ecuadorian obsidians. Application to provenance research of archeological samples

Obsidians from major Ecuadorian sources were analyzed by SQUID magnetometry and electron spin resonance (ESR). The association of these two techniques permits to differentiate obsidians from the sources of Cotopaxi volcano and from the Quiscatola and Mullumica–Callejones sources of the Chacana caldera, taking into account various parameters arising from the M vs. H cycles and the X-band ESR spectra. The analysis of 27 archeological samples coming from the prehispanic site of La Maná allowed us to infer that most of them come from the Mullumica–Callejones source.     

冲蚀磨损与冲蚀、空蚀交互磨损的对比研究

基于计算流体力学(computational fluid dynamics,CFD)方法,数值对比研究了在模拟水轮机工况中不同转速时,冲蚀与冲蚀、空蚀交互作用时,转盘表面的流场(压力场、流体浓度分布),然后在转盘式磨损装置上,进行了汽液固三相冲蚀与空蚀交互磨损试验.结果表明:对于冲蚀磨损来说,随着转速增加,压力增大,在冲蚀作用下加入空蚀磨损,压力增高,磨损加剧;而对于交互磨损来说,随着转速增加,转盘表面的空蚀磨损区域从空化孔附近开始沿着转盘旋转的反方向偏移,并且磨损程度加剧;数值计算的气泡较多且压力梯度较高区域和试验转盘磨损区域基本一致,数值计算结果和试验结果吻合得较好.     

Mathematical modeling of angular distortions in laser ranging of the <Emphasis Type="Italic">RadioAstron</Emphasis> satellite

A mathematical model for angular distortions in satellite laser ranging is constructed with allowance for effects of the theory of general relativity. For the RadioAstron mission satellite, it is shown that the angular distortions exceed the present-day accuracy of angular measurements in satellite laser ranging at all orbit points. Manifested most strikingly in the neighborhood of apogee, these distortions have to be taken into account in data processing performed within the framework of high-accuracy space exploration programs.     

Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

The potential of new natural products as an important source for the exploration and development of new drugs and crop protection products is a long way from being exhausted. The statistical analysis of the structures of the natural and synthetically derived compounds has shown conspicuous variations in structural types in the natural products derived from different natural sources, which can be utilized in the search for individual active substances. The occasionally voiced prepossession that natural products have already been sufficiently examined and therefore no more innovations are to be expected can definitely be rejected.     

Natural Product Synthesis on Polymeric Supports—Synthesis and Biological Evaluation of an Indolactam Library

Potent activators of protein kinase C in fibroblasts: This property was determined for several indolactam V analogues ( 1 ) with a new cell-based assay system. This tumor-promoting indole alkaloid and analogues thereof can be synthesized efficiently on the solid phase. The key steps of the combinatorial approach are a regioselective amination of the indole ring and an enantioselective enzymatic reaction.     

水资源管理研究进展

加强水资源管理是世界各国为提高水资源利用效率和应对水资源危机的重要举措之一,也是我国解决日益增长的水资源需求和水资源供给不足矛盾的关键。 水资源管理研究的领域较广、范围较大、主题较多,主要从国内外水资源管理的模式与制度、研究模型、研究重点领域以及研究热点四方面进行归纳综述,并以黑河流域为例,说明先进的水资源管理对提高水资源利用效率和应对水资源危机的重要性,可为我国探索水资源管理模式,建立适合国情的水资源管理制度提供科学基础。     

二分(0,mf-m+1)-图的正交(0,f)-因子分解

设G=(X,Y,E(G))是一个二分图,分别用V(G)=XUY和E(G)表示G的顶点集和边集.设f是定义在V(G)上的整数值函数且对(A)x∈V(G)有f(x)≥k.设H_1,H_2,…,H_k是G的k个顶点不相交的子图,且|E(H_i)|=m,1≤i≤k.本文证明了每个二分(0,mf-m+1)-图G有一个(0,f)-因子分解正交于Hi(i=1,2,…,k).     

Proteomics in cancer research: methods and application of array-based protein profiling technologies

With the human genome sequence now determined, the field of molecular medicine is moving beyond genomics to proteomics, the large-scale analysis of proteins.It is now possible to examine the expression of more than 1000 proteins using mass spectrometry technology coupled with various separation methods.Microarray technology is a new and efficient approach, for extracting relevant biomedical data and has a wide range of applications. It provides a versatile tool to study protein-protein, protein-nucleic acid, protein-lipid, enzyme-substrate and protein-drug interactions.This review paper will explore the key themes in proteomics and their application in clinical cancer research.