全文获取类型
收费全文 | 2475篇 |
免费 | 298篇 |
国内免费 | 334篇 |
专业分类
化学 | 1126篇 |
晶体学 | 42篇 |
力学 | 776篇 |
综合类 | 51篇 |
数学 | 209篇 |
物理学 | 903篇 |
出版年
2024年 | 9篇 |
2023年 | 21篇 |
2022年 | 56篇 |
2021年 | 70篇 |
2020年 | 88篇 |
2019年 | 79篇 |
2018年 | 69篇 |
2017年 | 115篇 |
2016年 | 129篇 |
2015年 | 107篇 |
2014年 | 90篇 |
2013年 | 218篇 |
2012年 | 124篇 |
2011年 | 148篇 |
2010年 | 111篇 |
2009年 | 150篇 |
2008年 | 140篇 |
2007年 | 138篇 |
2006年 | 156篇 |
2005年 | 148篇 |
2004年 | 129篇 |
2003年 | 111篇 |
2002年 | 91篇 |
2001年 | 75篇 |
2000年 | 72篇 |
1999年 | 73篇 |
1998年 | 58篇 |
1997年 | 43篇 |
1996年 | 48篇 |
1995年 | 51篇 |
1994年 | 44篇 |
1993年 | 28篇 |
1992年 | 18篇 |
1991年 | 21篇 |
1990年 | 15篇 |
1989年 | 19篇 |
1988年 | 11篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 8篇 |
1984年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
1971年 | 2篇 |
1957年 | 1篇 |
排序方式: 共有3107条查询结果,搜索用时 15 毫秒
111.
The incorporation of explicit ions to mimic the effect of ionic strength or to neutralize the overall charge on a system in free energy calculations using molecular dynamics simulations is investigated. The difference in the free energy of hydration between two triosephosphate isomerase inhibitors calculated at five different ion concentrations is used as an example. We show that the free energy difference can be highly sensitive to the presence of explicit ions even in cases where the mutation itself does not involve a change in the overall charge. The effect is most significant if the molecule carries a net charge close to the site mutated. Furthermore, it is shown that the introduction of a small number of ions can lead to very severe sampling problems suggesting that in practical calculations convergence can best be achieved by incorporating either no counterions or by simulating at high ionic strength to ensure sufficient sampling of the ion distribution. 相似文献
112.
113.
D. Sasireka E. Palaniyandi K. Iyakutti 《International journal of quantum chemistry》2004,99(3):142-152
Local lattice relaxation of substitutional donors in silicon investigated using self‐consistent multiple scattering Xα (MSXα) method within the framework of the standard muffin‐tin potential approximation is extended to substitutional donors in germanium and substitutional acceptors in both silicon and germanium. Incorporating the effect of lattice relaxation surrounding the impurity makes the model suitable for both shallow and deep levels. Chemical trends of some aspects of impurity states, such as local lattice relaxation and charge transfer, of the impurities both in silicon and germanium are inferred. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2004 相似文献
114.
Rabindra N. Roy Lakshmi N. Roy Jason G. Grant Mason P. Cummins Bennett J. Tabor III Sarah J. Richards Curtis A. Himes Bret R. Lively Penny L. Blackwell Ashley N. Simon 《Journal of solution chemistry》2002,31(11):861-872
The values of the second dissociation constant, pK
2, for the dissociation of the NH+ charge center of the zwitterionic buffer compounds 4-(N-morpholino)butanesulfonic acid (MOBS), and N-(2-hydroxyethyl)piperazine-N-4-butanesulfonic acid (HEPBS) have been determined from 5 to 55°C, including, 37°C at intervals of 5°C. The electromotive-force (emf) measurements have been made utilizing hydrogen electrodes and silver–silver chloride electrodes. The value of pK
2 for MOBS was found to be 7.702 ± 0.0005, and 8.284 ± 0.0004 for HEPBS, at 25°C, respectively. The related thermodynamic quantities, G
o, H
o, S
o, and C
p
o for the dissociation processes of MOBS and HEPBS have been derived from the temperature coefficients of pK
2. Both the MOBS and HEPBS buffer materials are useful as primary pH standards for the control of pH 7.3 to 8.6 in the region close to that of physiological fluids. 相似文献
115.
116.
Rabindra N. Roy Jill Cramer Victoria Randon Demara Willard Jennifer L. Walter William S. Good Amanda Kilker Lakshmi N. Roy 《Journal of solution chemistry》1998,27(5):425-434
The second acidic dissociation constants pK
2 of the ampholyte N-(2-hydroxyethyl) piperazine-N-2-hydroxypropanesulfonic acid (HEPPSO) have been determined at seven temperatures from 5 to 55°C from emf measurements utilizing hydrogen and silver–silver chloride cells without liquid junction. The thermodynamic quantities, G°, H°,S°, and C
p
o
have been calculated from the temperature coefficient of pK
2. At 25°C, the pK
2 = 8.042 and at 37°C, pK
2 = 7.876; hence, buffer solutions of HEPPSO and NaHEPPSOate are important for pH control in the region close to that of clinical fluids (blood serum). Conventional pH values from 5 to 55°C as well as those obtained from liquid junction correction at 25 and 37°C have been reported for three buffer solutions with the compositions (molality scale): (1) equimolal mixture of HEPPSO (0.04 m) + NaHEPPSOate (0.04 m) + NaCl (0.12 m); (2) HEPPSO (0.08 m) + NaHEPPSOate (0.08 m); and (3) HEPPSO (0.08 m) + NaHEPPSOate (0.08 m) + NaCl (0.08 m). 相似文献
117.
Godehard Sutmann 《Journal of Electroanalytical Chemistry》1998,450(2):1946
We have performed molecular dynamics computer simulations of water in homogeneous external electric fields which were varied in a wide range of field strengths. The dielectric response is found to be linear up to fields E0≈0.01 V/Å from where dielectric saturation effects become important. At fields of E0≈3 V/Å a phase transition into an ordered, ice-like structure is observed, which is stabilized through hydrogen-bonds. With an increasing external electric field, the frequency spectrum of the water dynamics shows a remarkable red shift of the intramolecular modes and a blue shift of the librational motions, where the frequency varies quadratically with the field strength. A simple analytical model is discussed which reproduces the observed behavior. 相似文献
118.
取代基对N—H…O=C氢键三聚体中氢键强度的影响 总被引:1,自引:0,他引:1
使用MP2方法研究了氢键三聚体中N-H…O=C氢键强度,探讨了氢键受体分子中不同取代基对N-H…O=C氢键强度的影响.研究表明,不同取代基对氢键三聚体中N-H…O=C氢键强度的影响是不同的:取代基为供电子基团,氢键键长r(H…O)缩短,氢键强度增强;取代基为吸电子基团,氢键键长r(H…O)伸长,氢键强度减弱.自然键轨道(NBO)分析表明,N-H…O=C氢键强度越强,氢键中氢原子的正电荷越多,氧原子的负电荷越多,质子供体和受体分子间的电荷转移越多.供电子基团使N-H…O=C氢键中氧原子的孤对电子n(O)对N-H的反键轨道σ~*(N-H)的二阶相互作用稳定化能增加,吸电子基团使这种二阶相互作用稳定化能减小.取代基对与其相近的N-H…O=C氢键影响更大. 相似文献
119.
30 wt% aligned untreated long hemp fibre/PLA (AUL) and aligned alkali treated long hemp fibre/PLA (AAL) composites were produced by film stacking and subjected to accelerated ageing. Accelerated ageing was carried out using UV irradiation and water spray at 50 °C for four different time intervals (250, 500, 750 and 1000 h). After accelerated ageing, tensile strength (TS), flexural strength, Young's modulus (YM), flexural modulus and mode I fracture toughness (KIc) were found to decrease and impact strength (IS) was found to increase for both AUL and AAL composites. AUL composites had greatest overall reduction in mechanical properties than that for AAL composites upon exposure to accelerated ageing environment. FTIR analysis and crystallinity contents of the accelerated aged composites support the results of the deterioration of mechanical properties upon exposure to accelerated ageing environment. 相似文献
120.
The effect of different storage temperatures on the physical properties of pectin solutions and gels
Gordon A. Morris Jonathan Castile Gary G. Adams Stephen E. Harding 《Polymer Degradation and Stability》2010,95(12):2670-2673
The stability (in terms of viscosity and gel strength) of pectin solutions and gels potentially plays an important role in their behaviour and functional properties in a wide range of applications and therefore any changes over time must be understood. The gel strength of pectin gels and intrinsic viscosity of pectin solutions at different temperatures (4 °C, 25 °C and 40 °C) have been investigated using a “rolling ball” viscometer and a texture analyser respectively. Both the intrinsic viscosity ([η]) and gel strength decrease with increased storage time, although this more pronounced at elevated temperatures. The changes in intrinsic viscosity with storage time and temperature were used to determine the depolymerisation constant (k). Pectin storage conditions and particularly temperature have an influence on depolymerisation, particularly elevated storage temperatures, but whether or not this will be detrimental to its intended application will depend on the functional significance of the changes that occur. In this case based on the previous diffusion studies on a model drug (paracetamol) we conclude that the decreases in viscosity and gel strength within the range observed have no detrimental effect on the drug release properties. 相似文献