激活型有机光声造影剂的应用

光声(PA)成像作为一种结合了光学和声学成像优势的新型成像方式,具有深层组织穿透和高空间分辨率等优点,在重大疾病的早期影像诊断方面有着巨大的应用前景.然而传统的PA造影剂依然存在信噪比低、选择性及特异性差等不足,容易产生假阳性诊断结果.激活型PA造影剂可以有效的降低背景噪声,并提升成像的灵敏度和特异性,是目前PA造影剂...     

A simple,corrosion-resistant flow cell for laser-induced photoacoustic spectroscopic detection of high-performance liquid chromatography effluents

Summary A simple, corrosion-resistant and non-destructive flow cell optimized for laser induced photoacoustic spectroscopic detection of HPLC effluents is described. The characteristics and analytical figures of merit of the flow cell are presented. Application of the flow cell to the detection of polynuclear aromatic hydrocarbons in HPLC effluent is demonstrated. Limits of detection were on the order of tenths of parts per million. Comparisons with the conventional UV absorbance detector and among various laser powers are discussed.     

Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy

Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging‐guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self‐assembly of two water‐soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4‐PcN4) and consequently enables the fabrication of PcS4‐PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4‐PcN4. In vivo evaluations suggest that PcS4‐PcN4 could not only efficiently visualize a tumor with high contrast through whole‐body photoacoustic imaging but also enable excellent photothermal therapy for cancer.     

脉冲光声量热法测量n-C4H9Co(Salen)H2O的Co-C键离解能

By using photoacoustic calorimetry, a photoacoustic measurement system is applied to determine the Co-C bond dissociation energy of n C₄H₉Co(Salen)H₂O, which is 116±8kJ·mol^-1. This value is in agreement with the activation enthalpy of the Co-C bond homolytic cleavage reaction that obtained by the kinetic method.     

用光声效应产生声拍

报道了用光声效应产生各种不同频率的声波，并用这些声波相干叠加产生声拍的实验原理，方法和实验结果。     

香兰素对甲苯胺希夫碱稀土配合物的红外光声光谱

研究了香兰素对甲苯胺希夫碱及其金属配合物在３８００－２００ ｃｍ＾－１范围的傅里叶变换红外光谱光谱，对主要谱带进行了经验归属。     

基于傅里叶变换红外光声光谱的包膜控释肥料聚合物膜疏水性的表征

以不饱和有机硅改性的丙烯酸酯为基材,在不同条件下制备了30种水基聚合物包膜控释肥料模型膜,测定了模型膜的溶胀度及模型膜的傅里叶变换红外光声光谱.分别以红外光声光谱和溶胀度为自变量和因变量进行简单相关分析,同时也构建了偏最小二乘模型,并利用该模型对模型膜的疏水性进行预测.结果表明,聚合物模型膜具有明显不同的疏水性,其红外光声光谱具有相似的吸收特征,但不同吸收带的相对强度发生明显改变;常用的简单相关分析无法实现模型膜疏水性的预测,表明模型膜的疏水性与谱区更多的特征峰相关;基于偏最小二乘法的多元校正分析具有很好的预测能力,模型的校正系数(R2)为0.9864,校正标准误差为0.70%,验证标准误差为1.92%.此模型可用于模型膜疏水性的预测.本方法样品用量少,测定快速,操作简便且可实现原位测定,为控释肥料包膜材料的研制提供新的手段.     

用脉冲光声法测量固体介质中声速

提出了一种利用脉冲光声技术测量固体介质中声速的方法,建立了由YAG激光器和超声探测器组成的实验系统,脉冲激光在固体表面产生脉冲超声波,通过测量脉冲声波在固体内多次反射后的出射信号及固体的厚度,即可算出固体介质中的声速.对黄铜及铝的测量结果表明,这是一种准确性较高的固体介质中声速测量方法.该测量方法可作为综合设计性物理实...     

基于脉冲石英增强光声光谱的中红外超高灵敏CO探测

发展了一种超高灵敏的CO痕量气体测量装置,该装置采用4.65μm脉冲式中红外外腔量子级联激光器作为激发光源,结合石英增强光声光谱技术,对2135~2225cm-1之间的CO基频振动光谱带R支进行连续光谱扫描。水被加入到被测气体中,以加快较慢的CO分子振动-平动弛豫率。在锁相放大器时间常数为3ms,激光器占空比和扫描速率为50%和18cm-1/s时,获得的最小探测极限为4.6×10-8(体积分数),与之对应的归一化噪声等效吸收系数为1.07×10-8 cm-1 W/Hz。