飞机撞击建(构)筑物研究进展

飞机撞击重要建(构)筑物会导致灾难性后果。本文从试验研究、理论分析、数值模拟等3个方面对飞机撞击建(构)筑物的国内外研究现状,相关研究难点、需要注意的问题和研究方向及趋势进行总结,包括:缩比试验的系统和验证,飞机撞击力模型,撞击所致局部破坏计算公式,飞机和建(构)筑物的精细化建模,撞击所致振动特性,撞击荷载和火荷载对结构的耦合毁伤效应,一般模型和精细化模型、解耦和耦合方法以及不同数值模拟程序计算结果的对比分析等方面,以期为后续研究提供参考。     

工程施工路径相关性的数值仿真

本文将损伤理论与时变力学耦联,形成用于模似施工的损伤时变力学方法,文中推导了基本方程和数值化算式。利用时变分析法对某地下煤层开采过程进行计算机仿真分析,给出了三种不同路径下开采引起地表沉陷的时空演化图,并进行对比分析。对体现出的位移、损伤与施工路径相关现象进行了探讨,并定量给出损伤时变分析下不同开采路径造成的最终力学状态的差别。本文中损伤时变力学方法为施工过程分析提供了一种新方法与手段。     

有限宽板孔边弹塑性变形测试

测量应变集中区域的弹塑性变形，对于研究材料损伤或微裂纹的产生，以预防宏观裂纹的产生及扩展具有重要的意义。为给航空发动机轮盘的损伤容限设计研究提供相关材料的力学实验参数，做了两个有限宽中心带孔试件的拉伸试验。试验中，采用单调逐级加、卸栽的循环加栽方式，并应用自动网格法和数字图像相关技术测量了孔用的全场位移分布。再应用最小二乘法将离散的位移分量拟合成二元多项式函数，求解出拉伸方向的应变分布，并给出孔边应力σ与孔边应变εy的关系曲线。     

基于粗糙集模糊神经网络的爆破振动危害预测

为了探索一种能克服单因素预测的局限性、提高爆破振动危害预测精度的方法,基于粗糙集模糊神经网络理论,建立了综合考虑爆破振动幅值、主频率、主频率持续时间及结构动力特性等10个因素的民房破坏程度预测模型;用铜绿山矿爆破振动和民房破坏情况观测数据,对该模型进行了训练和测试,测试结果与现场观测结果具有良好的一致性。研究表明:粗糙集理论可将现场数据进行属性约简,简化输入变量,缩小神经网络的搜索空间,改善爆破振动的预测性能;基于粗糙集模糊神经网络理论的爆破振动危害预测模型,能更好地考虑各种因素对危害程度的综合影响,避免了单因素预测的局限性。     

求解层间界面反平面剪切破坏的剪切梁模型(Ⅰ)——基本特性

在反平面剪切载荷及侧压力共同作用下引起的裂纹及裂纹扩展导致的层间界面失效,是岩土工程层间界面及砌体结构中界面层上典型的失效方式.运用弹性力学和断裂力学的理论原理,提出了能够反映上述层间界面断裂失效问题力学特性的剪切梁模型.文中采用具有应力软化特性的“粘性裂纹”(内聚力裂纹)模型来表述层间裂纹前方损伤过程区的本构行为.对通过粘性层结合在一起的两个弹性板,在反平面剪切载荷及侧压力共同作用下的力学行为作了解析分析计算,研究了层间界面裂纹扩展规律.     

考虑车辆随机停放的停车楼减震设计与可靠度分析

在停车楼的设计中通常将车辆荷载以活荷载的方式均匀分布到结构上,实际上受车辆随机停放的影响,停车楼结构整体质量中心偏移,一旦结构遭遇罕遇地震时,车辆的随机停放可能造成停车楼结构发生扭转破坏.本文在传统减震设计方法的基础上考虑车辆活荷载的随机性,并从可靠度的角度验算减震结构在大震作用下的倒塌概率.结果表明,相同的减震设计布...     

Antiproliferation- and Apoptosis-Inducible Effects of a Novel Nitrated [6,6,6]Tricycle Derivative (SK2) on Oral Cancer Cells

The benzo-fused dioxabicyclo[3.3.1]nonane core is the central framework in several natural products. Using this core, we had developed a novel nitrated [6,6,6]tricycle-derived compound containing an n-butyloxy group, namely, SK2. The anticancer potential of SK2 was not assessed. This study aimed to determine the antiproliferative function and investigated possible mechanisms of SK2 acting on oral cancer cells. SK2 preferentially killed oral cancer cells but caused no harmful effect on non-malignant oral cells. After the SK2 exposure of oral cancer cells, cells in the sub-G1 phase accumulated. This apoptosis-like outcome of SK2 treatment was validated to be apoptosis via observing an increasing annexin V population. Mechanistically, apoptosis signalers such as pancaspase, caspases 8, caspase 9, and caspase 3 were activated by SK2 in oral cancer cells. SK2 induced oxidative-stress-associated changes. Furthermore, SK2 caused DNA damage (γH2AX and 8-hydroxy-2′-deoxyguanosine). In conclusion, a novel nitrated [6,6,6]tricycle-derived compound, SK2, exhibits a preferential antiproliferative effect on oral cancer cells, accompanied by apoptosis, oxidative stress, and DNA damage.     

Synthesis,spectroscopic characterization (IR, 1H, 13C and 119Sn NMR,electrospray mass spectrometry) and toxicity of new organotin(IV) complexes with N,N′,O‐ and N,N′,S‐scorpionate ligands

New organotin(IV) derivatives containing the anionic ligands bis(3,5‐dimethylpyrazol‐1‐yl)dithioacetate [LCS₂]⁻ and bis(3,5‐dimethylpyrazol‐1‐yl)acetate [LCO₂]⁻ have been synthesized from reaction between (CH₃)₂SnCl₂ and lithium salts of the ligands. Mononuclear complexes of the type {[LCX₂](CH₃)₂SnCl} (X = S or O) have been obtained and fully characterized by elemental analyses and FT‐IR in the solid state and by NMR (¹H, ¹³C and ¹¹⁹Sn) spectroscopy, conductivity measurements and electrospray ionization mass spectrometry in solution. The acute toxicity of new organotin(IV) derivatives on rat was studied, comparing their effect with those of dimethyltin chloride (CH₃)₂SnCl₂. The comparison of LD₅₀ of organotin(IV) complexes and (CH₃)₂SnCl₂ administered intraperitoneally, as a single dose, evaluated in vivo on rats, showed that toxicity decreases as follows: (CH₃)₂SnCl₂ > LCO₂ > LCS₂. The effect of these organotin(IV) complexes on DNA was evaluated in vitro and in vivo on rats treated with different doses of these compounds (1/20 LD₅₀ and 1/100 LD₅₀). The lymphocyte DNA status was assessed by the comet assay, a rapid and sensitive single‐cell electrophoresis technique, used to detect primary DNA damage in individual cells. After 36 h from the start of treatment the two new organotin(IV) derivatives induced a significant rise in comet assay parameters, indicating an increasing presence of damaged DNA. Copyright © 2005 John Wiley & Sons, Ltd.     

Radiation damage in soft X-ray microscopy

The rates of chemical transformation by radiation damage of polystyrene (PS), poly(methyl methacrylate) (PMMA), and fibrinogen (Fg) in a X-ray photoemission electron microscope (X-PEEM) and in a scanning transmission X-ray microscope (STXM) have been measured quantitatively using synchrotron radiation. As part of the method of dose evaluation in X-PEEM, the characteristic (1/e) sampling depth of X-PEEM for polystyrene in the C 1s region was measured to be 4 ± 1 nm. Critical doses for chemical change as monitored by changes in the X-ray absorption spectra are 80 (12), 280 (40) and 1230 (180) MGy (1 MGy = 6.242*ρ eV/nm³, where ρ is the polymer density in g/cm³) at 300 eV photon energy for PMMA, Fg and PS, respectively. The critical dose for each material is comparable in X-PEEM and STXM and the values cited are thus the mean of the values determined by X-PEEM and STXM. C 1s, N 1s and O 1s spectroscopy of the damaged materials is used to gain insight into the chemical changes that soft X-rays induce in these materials.     

A GENERALIZED MODELING FOR CEMENT-BASED MATERIALS UNDER LARGE RANGE OF COMPRESSION STATE

The aim of this study is to describe the main behavior of cement-based materials under large compression state based on the recent experimental research. In this paper, the strainstress relations are firstly analyzed and confining pressure state is regarded as low/medium/high state. A generalized cup modeling is introduced by a coupled deviatoric shearing, pore collapse and damage mechanism within thermodynamic framework. A series of numerical simulations are performed for the considered cement paste and concrete. Comparisons between numerical predictions and experimental results show that the proposed model is able to describe the main features of mechanical behavior under large range of compression state.