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31.
Historically, due to the size and nature of the instrumentation, highly skilled laboratory professionals performed clinical
testing in centralized laboratories. Today’s clinicians demand realtime test data at the point of care. This has led to a
new generation of compact, portable instruments permitting ”laboratory” testing to be performed at or near the patient’s bedside
by nonlaboratory workers who are unfamiliar with testing practices. Poorly controlled testing processes leading to poor quality
test results are an insidious problem facing point of care testing today. Manufacturers are addressing this issue through
instrument design. Providers of clinical test results, regardless of location, working with manufacturers and regulators must
create and manage complete test systems that eliminate or minimize sources of error. The National Committee for Clinical Laboratory
Standards (NCCLS) in its EP18 guideline, ”Quality management for unit-use testing,” has developed a quality management system
approach specifically for test devices used for point of care testing (POCT). Simply stated, EP18 utilizes a ”sources of error”
matrix to identify and address potential errors that can impact the test result. The key is the quality systems approach where
all stakeholders – professionals, manufacturers and regulators – collaboratively seek ways to manage errors and ensure quality. We illustrate the use of one quality systems approach, EP18, as a means to advance the quality of test results at point of
care.
Received: 26 June, 2002 Accepted: 17 July 2002
Presented at the European Conference on Quality in the Spotlight in Medical Laboratories, 7–9 October 2001, Antwerp, Belgium
Abbreviations NCCLS National Committee for Clinical Laboratory Standards (formerly) · POCT point of care testing · QC quality control ·
HACCP hazard analysis critical control points · CLIA clinical laboratory improvement amendments (of 1988)
Correspondence to S. S. Ehrmeyer 相似文献
32.
Siu Kay Wong 《Accreditation and quality assurance》2005,10(8):409-414
Proficiency testing (PT) is an essential tool used by laboratory accreditation bodies to assess the competency of laboratories.
Because of limited resources of PT providers or for other reasons, the assigned reference value used in the calculation of
z-score values has usually been derived from some sort of consensus value obtained by central tendency estimators such as the
arithmetic mean or robust mean. However, if the assigned reference value deviates significantly from the ‘true value’ of the
analyte in the test material, laboratories’ performance will be evaluated incorrectly. This paper evaluates the use of consensus
values in proficiency testing programmes using the Monte Carlo simulation technique. The results indicated that the deviation
of the assigned value from the true value could be as large as 40%, depending on the parameters of the proficiency testing
programmes under investigation such as sample homogeneity, number of participant laboratories, concentration level, method
precision and laboratory bias. To study how these parameters affect the degree of discrepancy between the consensus value
and the true value, a fractional factorial design was also applied. The findings indicate that the number of participating
laboratories and the distribution of laboratory bias were the prime two factors affecting the deviation of the consensus value
from the true value. 相似文献
33.
Terry Spencer 《Accreditation and quality assurance》2005,10(6):308-314
This presentation deals with issues of comparability and traceability in food analysis in Australia from several perspectives. This includes the current national (Australian) and increasingly international (Codex) performance-based approach to food analysis. The Australian food regulatory process will be described, particularly those aspects that impact on the analysis of food in a regulatory sense. This section will also describe two areas where specific methods have been mandated in legislation and discuss two case studies where the analytical method has impacted on the elaboration of standards. Other areas to be covered include regulation/requirements relating to supply/availability of reference materials, the use of proficiency testing as a means of ensuring comparability, and, finally, some thoughts on what role BIPM/CCQM may play in the analysis of food.Electronic Supplementary Material Supplementary material is available for this article at
相似文献
Terry SpencerEmail: Phone: +612-6213-6102Fax: +612-6213-6815 |
34.
The robustness testing of a normal-phase liquid chromatographic (LC) method for the determination of R-timolol and other related substances in S-timolol maleate was performed applying a two-level Plackett-Burman design. Two qualitative and five quantitative factors were examined. Two types of responses were considered, qualitative, i.e. chromatographic performance criteria, and quantitative ones. The latter were taken into account to determine if the analytical procedure was robust. The quantitative responses were the contents of R-timolol in two S-timolol maleate samples. Even though some significant factor effects were observed on the qualitative responses, the R-timolol contents were not significantly different from those observed at nominal conditions, which demonstrated the robustness of the procedure.Since the experiments of the Plackett-Burman design can be assimilated to laboratories in an interlaboratory study, uncertainty can be evaluated using the robustness test data. The robustness test was set-up in such a way that the required variances could be estimated. It was shown that the robustness set-up allows estimating the reproducibility uncertainty without performing an interlaboratory study. 相似文献
35.
Capillary gc is now rapidly expanding. Naturally, initiation is most often attempted on the basis of the experience acquired with packed columns. However, such an extrapolation is successful only if a number of essential peculiarities of capillary gc are considered. Based on practical examples this paper discusses six essential details: 1) design and maintenance of the gas flow paths, 2) the greatly increased importance of sampling technique, which should not be confined just to stream splitting, 3) the problems in quantitative analysis arising from small sample size, 4) specific sources of trouble related to small amounts of liquid phase, 5) specific arguments for the choice of the carrier gas, clearly pointing to hydrogen as the ideal carrier and, 6) the different way to approach column production. Figures for all selected examples are given. 相似文献
36.
Summary The quantitative use of high speed capillary electrophoresis (HSCE) is examined by applying high voltages across short capillaries.
Acceptable performance in terms of injection precision and migration times were achieved within 1–2 minute analysis times.
HSCE was used for the novel CE application of dissolution test sample solution analysis. The results generated by HSCE compared
well with those generated using validated on-line UV absorbance measurements. It is concluded that HSCE is a viable alternative
and supplement to standard analytical methods employed in dissolution test analysis. 相似文献
37.
Summary The effects of concentration, separation and spectral similarity as factors influencing the accuracy of iterative target testing
factor analysis (ITT-FA) are investigated for three component systems by the application of analysis of variance (ANOVAR).
ANOVAR is applied over a range of peak separations to map the changing effects of the three factors with increasing overlap.
Two error responses were measured and analysed, (a) Relative cluster error (RCE) a measure of the error over all peaks in
a cluster and (b) Relative peak error (RPE) the error of an individual peak. Multicomponent analysis (MCA) a method requiringa priori spectral information, is used as a referee method for ITT-FA. 相似文献
38.
Noel V. Stanton Tracy Fritsch Ciaran Geraghty Mary Frances Verostek Bruce Weiner Patrick J. Parsons 《Accreditation and quality assurance》2006,11(11):590-592
Following implementation of the CLIA ‘88 laboratory regulations, the primary role of proficiency testing (external quality assessment, PT) in the U.S. has been widely viewed as one of assuring regulatory compliance. PT can also be an effective tool for detecting widespread analytical problems, subject to limitations based on the method of PT assigned value determination. A recent case study describes the role of two PT programs in detecting and resolving a calibration bias in the LeadCare blood lead analyzer, and illustrates the limitations of peer-group target determination in fulfilling that PT role. 相似文献
39.
The development of novel microanalytical techniques forin situ chemical characterization of the terrestrial subsurface environment has grown significantly over the last decade, particularly those instruments that are interfaced to the cone penetrometer. Cone penetrometer testing (CPT) has emerged as an effective means to introduce samplers and probes forin situ analysis of contaminants in soil and groundwater matrices. A variety ofin situ chemical samplers for CPT have been developed that can be driven into the subsurface to collect soil gas, groundwater, or soil samples at depth, thus providing a means of determining the vertical and horizontal extent of contamination. Cone penetrometer testing is also being explored as a means to deliverin situ subsurface sensor probes, including probes based on laser-induced fluorescence, Raman, and infrared spectroscopies for organics; on laser-induced breakdown and X-ray fluorescence spectroscopies for heavy metals; and on passive gamma-ray spectroscopy for radionuclides. The range of analytical technologies used in CPT for the determination of organic and inorganic species in the subsurface is described. 相似文献
40.
H. R. Veenendaal P. M. van Berkel G. de Jong P. K. Baggelaar 《Accreditation and quality assurance》2007,12(7):365-368
Due to the relatively large spread in the results of microbiological proficiency tests, the z-scores are often not able to detect zero or low results as being ‘bad’ results. This paper describes an adapted z-score based on the average or the standard deviation of the 50% ‘highest’ results. The combination of the adapted z-scores of four samples enables a better judgement of the performance of each laboratory.
Papers published in this section do not necessarily reflect the opinion of the Editors, the Editorial Board or the Publisher. 相似文献