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291.
Diabetes, a multifunctional disease and a major cause of morbidity and mortality in the industrialized countries, strongly associates with the development and progression of atherosclerosis. One of the consequences of high level of glucose in the blood circulation is glycation of long-lived proteins, such as collagen I, the most abundant component of the extracellular matrix (ECM) in the arterial wall. Glycation is a long-lasting process that involves the reaction between a carbonyl group of the sugar and an amino group of the protein, usually a lysine residue. This reaction generates an Amadori product that may evolve in advanced glycation end products (AGEs). AGEs, as reactive molecules, can provoke cross-linking of collagen I fibrils. Since binding of low-density lipoproteins (LDLs) to the ECM of the inner layer of the arterial wall, the intima, has been implicated to be involved in the onset of the development of an atherosclerotic plaque, collagen modifications, which can affect the affinity of native and oxidized LDL for collagen I, can promote the entrapment of LDLs in the intima and accelerate the progression of atherosclerosis.In this study, open tubular capillary electrochromatography is proposed as a new microreactor to study in situ glycation of collagen I. The kinetics of glycation was first investigated in a fused silica collagen I-coated capillary. Dimethyl sulphoxide, injected as an electroosmotic flow marker, gave information about the charge of coating. Native and oxidized LDL, and selected peptide fragments from apolipoprotein B-100, the protein covering LDL particles, were injected as marker compounds to clarify the interactions between LDLs and the glycated collagen I coating. The method proposed is simple and inexpensive, since only small amounts of collagen and LDL are required. Atomic force microscopy images complemented our studies, highlighting the difference between unmodified and glycated collagen I surfaces. 相似文献
292.
Thomas J. Bruno Lisa S. OttTara M. Lovestead Marcia L. Huber 《Journal of chromatography. A》2010,1217(16):2703-2715
The analysis of complex fluids such as crude oils, fuels, vegetable oils and mixed waste streams poses significant challenges arising primarily from the multiplicity of components, the different properties of the components (polarity, polarizability, etc.) and matrix properties. We have recently introduced an analytical strategy that simplifies many of these analyses, and provides the added potential of linking compositional information with physical property information. This aspect can be used to facilitate equation of state development for the complex fluids. In addition to chemical characterization, the approach provides the ability to calculate thermodynamic properties for such complex heterogeneous streams. The technique is based on the advanced distillation curve (ADC) metrology, which separates a complex fluid by distillation into fractions that are sampled, and for which thermodynamically consistent temperatures are measured at atmospheric pressure. The collected sample fractions can be analyzed by any method that is appropriate. The analytical methods we have applied include gas chromatography (with flame ionization, mass spectrometric and sulfur chemiluminescence detection), thin layer chromatography, FTIR, corrosivity analysis, neutron activation analysis and cold neutron prompt gamma activation analysis. By far, the most widely used analytical technique we have used with the ADC is gas chromatography. This has enabled us to study finished fuels (gasoline, diesel fuels, aviation fuels, rocket propellants), crude oils (including a crude oil made from swine manure) and waste oils streams (used automotive and transformer oils). In this special issue of the Journal of Chromatography, specifically dedicated to extraction technologies, we describe the essential features of the advanced distillation curve metrology as an analytical strategy for complex fluids. 相似文献
293.
本文基于Pythagorean-hodograph (PH)曲线和代数双曲线的良好几何特性,构造了Pythagorean-Hodograph Hyperbolic (PH-H)曲线,并给出了PH-H曲线的定义以及相应性质.同时,分别利用Hyperbolic基函数和Algebraic Hyperbolic (AH) B\''ezier基函数,得到了平面三次AH B\''ezier曲线为PH曲线的两个不同的充要条件.此外,三次PH-H曲线也被用于求解具有确定解的$G^1$ Hermite插值问题.文中给出了具体实例来说明我们的方法. 相似文献
294.
介绍了验证PN结伏安关系特性实验的实验原理,并利用绘图软件Origin7.5对实验数据进行处理.结果表明,PN结的扩散电流和两端的正向电压之间满足指数关系.通过与理论公式的比较,准确地测出了玻尔兹曼常数. 相似文献
295.
应用E-GOS(E-Gamma Over Spin)曲线方法研究了A≈110质量区奇A核结构随角动量增加的演化, 发现随着角动量的增加原子核的激发特性从振动逐渐演化为转动。 The E-GOS(E-Gamma Over Spin)curves were used to investigate the structure evolution in the odd A nuclei around A≈110 as a function of spin. The result shows that there is a clear transition from vibration to rotation while increasing spin. 相似文献
296.
Lithium borate (Li2B4O7) is a low Zeff, tissue equivalent material that is commonly used for medical dosimetry using the thermoluminescence (TL) technique. Nanocrystals of lithium borate were synthesized by the combustion method for the first time in the laboratory. TL characteristics of the synthesized material were studied and compared with those of commercially available microcrystalline Li2B4O7. The optimum pre-irradiation annealing condition was found to be 300 °C for 10 min and that of post-irradiation annealing was 300 °C for 30 min. The synthesized Li2B4O7 nanophosphor has very poor sensitivity for low doses of gamma up to 101 Gy whereas from 101 to 4.5×102 Gy this phosphor exhibits a linear response and then from 4.5×102 to 103 Gy it shows supralinearity. Thermoluminescence properties of Li2B4O7 nanophosphor doped with Cu has also been investigated in this paper. It shows low fading and a linear response over a wide range of gamma radiation from 1×102 to 5×103 Gy. Therefore the synthesized lithium borate nanophosphor doped with Cu may be used for high dose measurements of gamma radiations. 相似文献
297.
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299.
On the basis of the mean value of electrical breakdown time delay and the standard deviation of electrical breakdown time delay σ dependence on the afterglow period τ, the mechanisms which dominantly influence to breakdown initiation in nitrogen were separated. It was shown that the positive ions formed in mutual collision of long‐lived metastable molecules have a dominant role in breakdown initiation for τ values up to 70 ms. The metastable molecules were derived from previous breakdown and discharge. In this case σ ≪ td and the total time delay td is approximately equal to formative time tf which decreases in value with the increase of overvoltage. When positive ions have a dominant role in the breakdown initiation the Gaussian distribution describes data of td ≈ tf very well. For τ > 1 s, N (4S) atoms formed in previous breakdown and discharge, have a dominant role in the breakdown initiation. Then, σ ≈ and Laue's distribution, which is valid for statistical time delay ts, describes td data very well (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
300.