Extracorporeal cardiac shock wave therapy for ischemic heart disease

Prognosis of severe ischemic heart disease with no indication of percutaneous coronary intervention or coronary artery bypass grafting still remains poor. Extracorporeal shock wave therapy was introduced for medical therapy more than 20 years ago to break up kidney stones. We have demonstrated that extracorporeal cardiac shock wave therapy at a low level of ~10% of energy density that used for urinary lithotripsy treatment, effectively induces coronary angiogenesis and improves myocardial ischemia in a porcine model of chronic myocardial ischemia in vivo. On the basis of the promising results in animal studies, we have recently developed a new, non-invasive angiogenic therapy with low-energy shock waves for ischemic heart disease. Our extracorporeal cardiac shock wave therapy improved symptoms and myocardial ischemia in patients with severe coronary artery disease. These beneficial effects of the shock wave therapy persisted for at least 12 months. Importantly, no procedural complications or adverse effects were noted. These results indicate that our extracorporeal cardiac shock wave therapy is an effective and non-invasive treatment for ischemic heart disease. To further confirm the usefulness and safety of our SW therapy, we are currently conducting the second clinical trial in a randomized and placebo-controlled manner.      

Regulating Effect of Allicin(Diallyldisulfid-S-Oxide) on Respiration Function of Mitochondria from Beef Heart

To probe into regulating functions of allicin, diallyldisulfid-S-oxide, on electron transport in the inner membrane of mitochondria isolated from beef heart, under the anaerobic, hypoxia, and oxygenating conditions in the presence of rotenone(complex I inhibitor) at 37 °C, we optimized the isolation method for isolating mitochondria from beef heart and used the technique for measuring dissolved oxygen content at the right moment so as to investigate the effects of allicin on the respiratory control of mitochondria in state 4 and state 3, P/O ratio, and respiratory control ratio(RCR). The results show that the optimized isolated requirements were that all the operations were always kept at 0―4 °C, the ratio between sample and isolation medium was 1:4, the filter was a four-layer gauze, two centrifugations in different sections. First section: 2500g, 10 min; second section 7000g, 20 min. The results indicate that the capacity of dissolved oxygen in state 3 was increased and that of dissolved oxygen in state 4 was almost stabilized in mitochondria from beef heart.     

微量金属元素含量与高胆固醇致病关系的研究

1 对象与方法 1.1 观察对象 住院冠心病人44例,男女各22名,年龄45～77岁,平均62.1岁.临床诊断标准符合WHO标准 ,即典型心绞痛,伴心电图ST段水平下移≥0.05mV,T波倒置.对照组42例,选择经体检,心电图、B超、血脂、血糖、肝、肾功能等各项检查,排除了与心脑血管有关的疾病的健康人 ,并在年龄、性别方面作了适当匹配.     

Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces

The aim of this study was to minimize the risk of life-threatening thromboembolism in the ventricle through the use of a new biomimetic heart valve based on metal–polymer composites. Finite volume element simulations of blood adhesion to the material were carried out, encompassing radial flow and the cone and plane test together with determination of the effect of boundary conditions. Both tilt-disc and bicuspid valves do not have optimized blood flow due to their design based on rigid valve materials (leaflet made of pyrolytic carbon). The main objective was the development of materials with specific properties dedicated to contact with blood. Materials were evaluated by dynamic tests using blood, concentrates, and whole human blood. Hemostability tests under hydrodynamic conditions were related to the mechanical properties of thin-film materials obtained from tribological tests. The quality of the coatings was high enough to avoid damage to the coating even as they were exposed up to maximum loading. Analysis towards blood concentrates of the hydrogenated carbon sample and the nitrogen-doped hydrogenated carbon sample revealed that the interaction of the coating with erythrocytes was the strongest. Hemocompatibility evaluation under hydrodynamic conditions confirmed very good properties of the developed coatings.     

舌体高光谱的高血压患者中合并冠心病的筛查方法

高血压合并冠心病是高血压疾病的一类严重合并症.目前高血压患者对合并冠心病的情况检测不及时,容易导致严重事件的发生,其致残率、致死率极高,严重影响患者的生活质量.因此对高血压患者合并冠心病的早期发现对预防更严重事件的发生显得尤为重要.舌体信息与心血管功能关系密切,为此,提出一种基于舌体高光谱用于高血压患者中合并冠心病筛查...     

一种基于欧拉的非接触式检测生理参数的加速方法

成像式光电容积描记技术(IPPG)是近几年发展起来的一种新的检测生理参数的技术.欧拉视频放大技术以一种空间多尺度的方法来研究像素随时间的变化,揭示了视频中微弱运动的变化,使得现代的医学技术更好地发展.在环境光照射下使用智能手机的摄像头采集人脸部视频,将原始视频信号进行欧拉放大提取心率和血氧饱和度.传统的欧拉放大技术基于YIQ色彩空间,所以要对采集到的视频做一个色彩空间转换,放大完后再由YIQ空间转换到RGB空间,这种方法计算量大,耗时多,不利于生理参数的实时检测.提出一种不对色彩空间进行转换,直接利用RGB空间对视频进行放大的方法.与传统方法相比,RGB色彩空间测量的准确性与YIQ色彩空间具有高度的一致性,同时处理速度提升了百分之三十以上.     

Estimation of the possibility of using dynamic spectroscopy to analyze biological scattering media

An attempt was made to extend the field of application of the methods of dynamic spectroscopy to analyze media with a large volume content of scatterers. It is shown that under conditions of multiple scattering the temporal spectrum S(w) depends not only on the dimensions of the scatterers, but also on their optical characteristics. A correlation dependence between the width of the temporal spectrum S(w) and the dimensions of aggregates of erythrocytes has been established. The existence of a correlation between the width of the temporal spectrum S(w) and important clinical characteristics of blood, such as the erythrocyte settling rate and the concentration of lipoproteins, has been found. Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 64, No. 1, pp. 97–102, January–February, 1997.     

铅中毒引起心脏风湿性心瓣膜病样表现一例

讨论了一例铅中毒引起的心脏风湿性心瓣膜病样表现。     

Trace Anion Determination in Concentrated Nitric Acid by Means of Two Coupled Ion Chromatography Systems

The analysis of trace anions in concentrated nitric acid requires two online coupled ion chromatography systems for the required selectivity. The first system acts as preseparator of the trace anions from the matrix compounds. The trace anions are preconcentrated by means of a heart-cut valve and a concentrator column. The second system acts as detection device and allows sensitive determination of chloride, sulfate and phosphate.Several commercial columns were tested for usefulness in system no. 1. Eventually the anion exchanger for the first system was developed in-house so as to obtain a maximum selectivity difference between the analytes and the matrix anions. The column accepts a total amount of 22µmol nitric acid per run without losing the resolution between analytes and matrix.The second system utilizes a high performance anion exchanger for quantification of the analytes. Recoveries found are 80% to 100% for phosphate and around 100% for sulfate and chloride. Detection limits for chloride, sulfate and phosphate in concentrated nitric acid (69% w/w) are 0.1, 1 and 5mgL^–1, respectively.