耦合可激发介质中螺旋波的控制研究

采用Br模型研究了三层耦合可激发介质中螺旋波的控制.相邻层之间采用双向耦合.利用加在第二层介质上的局域周期信号产生的平面波来消除螺旋波.数值模拟表明:只有当三层介质的耦合满足一定条件才可能实现螺旋波的控制,可以通过耦合互补方式实现螺旋波的控制;平面波与低频螺旋波的相互作用可以产生高频螺旋波,导致螺旋波不能被消除;存在优化的驱动宽度,过大或过小的驱动宽度需要增加第一、三层介质的耦合强度.观察到控制结果依赖控制时机的现象.研究结果可用于植入式心脏除颤器的设计.     

多尺度策略和替代数据检验——HRV时间不可逆性分析的两个要素

本文通过应用基于多尺度思想的（Pm,Gm）平面法和替代数据检验,对来自于不同人群以及来自于健康年轻人清醒、睡眠状态下的心率变异性（heartratevariability,HRV）进行了时间不可逆性分析．结果表明：健康成人的HRV普遍存在着时间不可逆性,而随着疾病的出现,这种不可逆性减弱但并非消失,大部分（超过75％）充血性心力衰竭患者的HRV仍具有时间不可逆性：健康年轻人的HRV不可逆性存在着昼夜节律和显著的昼夜差异,夜间睡眠时不可逆性更强．我们认为：由于产生HRV的心脏动力系统具有复杂的延迟特性,在对HRV进行时间不可逆分析时,为了得到更可靠的结论,建议采用多尺度策略以及进行替代数据检验．综合考虑上述两个因素的分析方法也较好地统一了已有报道的不同结论．     

产前胎儿超声心动图在先天性心脏病产前诊断中的应用价值

本研究探讨了产前胎儿超声心动图在先天性心脏病产前诊断中的应用价值,选取3000例孕妇作为研究对象,均于孕20? 24周接受胎儿超声心动图和普通彩色多普勒超声检查.以妊娠结局为参照,分析了产前胎儿超声心动图检查和普通彩色多普勒超声诊断先天性心脏病的敏感性、特异性和准确度,并比较了不同检查切面对先天性心脏病的产前诊断率.结...     

Comprehensive chemical profiling and quantification of Shexiang Xintongning tablets by integrating liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry

Shexiang Xintongning tablet (SXXTN) is a traditional Chinese medicine (TCM) preparation for the treatment of coronary heart disease (CHD) angina pectoris. However, due to the complexity of the compounds in SXXTN, the active chemical components responsible for the therapeutic effect are still ambiguous. The purpose of our study was to characterize the chemical profile of SXXTN and quantify the representative chemicals. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-QTOF MS) method and gas chromatograph coupled with mass spectrometry (GC–MS) method were utilized to identify the chemical constituents of SXXTN. A total of 140 compounds including alkaloids, ginsenosides, organic acids, esters, triterpenes, phthalides and amino acid were identified in accordance with their retention times, accurate masses and characteristic MS/MS fragment patterns. Forty-four volatile components were characterized by GC–MS through NIST database matching. In the further research of quantitative analysis, 40 non-volatile compounds and 17 volatile compounds were determined and successfully applied for detecting in 7 batches of SXXTN samples by high performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (HPLC-QQQ MS) and gas chromatograph coupled with triple-quadrupole tandem mass spectrometry (GC-QQQ MS) in multiple reaction monitoring (MRM) mode, respectively. The quantitative methods were verified in linearity, precision, repeatability stability and recovery. The above results indicated that the established method was practical and reliable for synthetical quality evaluation of SXXTN. In addition, our study might supplement the chemical evidence for disclosing the material basis of its therapeutic effects.     

Kinetic features of Gualou-Xiebai-Banxia decoction,a classical traditional Chinese medicine formula,in rat plasma and intestine content based on its metabolic profile

Gualou-Xiebai-Banxia decoction (GXB) is a famous classical traditional Chinese medicine (TCM) formula for the treatment of coronary heart disease (CHD, namely chest stuffiness and pain syndrome in Chinese medicine). Compared with Gualou-Xiebai-Baijiu decoction, which only consists of Trichosanthis Pericarpium (TP), Allii Macrostemonis Bulbus (AMB) and wine, GXB comprises one additional herbal medicine, Pinellinae Rhizoma Praeparatum (PRP). However, due to a lack of kinetic profile studies on GXB, its in vivo components with high exposure remain unknown, making it difficult to interpret bioactive components likely linked to its efficacy, but also fails to provide substance-related evidence for reflecting the compatibility in GXB. The goal of this study was to systematically characterize the kinetic features of GXB in rat plasma and intestine content for revealing its in vivo high-exposure components on the basis of their metabolic fates, and to compare the kinetic differences between GXB and GXB-dePRP (GXB deducted PRP) for describing the chemical contribution of PRP to the compatibility in GXB. Firstly, the metabolic profile of GXB was systematically investigated by UPLC-Q/TOF-MS. Subsequently, quantitative methods for representative xenobiotics in rat plasma and intestine content were respectively validated and developed by UPLC-TQ-MS. Then, the established approaches were successfully applied to characterize the kinetic features of GXB through estimating pharmacokinetic parameters. These results showed that only a few kinds of xenobiotics at low exposure levels were observed in plasma, while various xenobiotics possessed high exposure in intestine content. Among them, steroidal saponins and triterpenoid saponins displayed relatively high exposure in plasma and intestine content, which are likely associated with the therapeutic effects of GXB. Moreover, there were no significant differences between metabolic profiles of GXB and GXB-dePRP, whereas the pharmacokinetic parameters, including area under the concentration–time curve (AUC) and C_max (p < 0.05) for most xenobiotics in GXB were significantly larger than those in GXB-dePRP, implying that the introduction of PRP improved the bioavailability of constituents from TP and AMB. Altogether, this study laid a solid foundation and provided theoretical guidance for further clarification of bioactive components of GXB, as well as the synergistic effect of PRP to the compatibility in GXB.